Cia peb tham txog hydroxypropyl methyl cellulose HPMC thiab ntsuas nws cov viscosity li cas.Lub viscosity ntawm no yog hais txog qhov pom tseeb viscosity, uas yog ib qho tseem ceeb siv rau hydroxypropyl methyl cellulose.
Txuj.Cov kev ntsuas ib txwm muaj yog ntsuas viscosity rotational, ntsuas capillary viscosity thiab poob viscosity ntsuas.Txoj kev txiav txim siab ntawm hydroxypropyl methyl cellulose yog capillary adhesion.
Txoj kev txiav txim siab degree, siv Uchs viscometer.Feem ntau qhov kev txiav txim siab ntawm cov tshuaj yog 2% aqueous tov, cov mis yog: V = Kdt.V yog qhov viscosity hauv mpa.s thiab K yog qhov viscometer tas li.
D yog qhov ceev ntawm qhov kub thiab txias thiab T yog lub sijhawm los ntawm sab saum toj mus rau hauv qab los ntawm viscometer hauv vib nas this.Txoj kev ua haujlwm no yog ntau cumbersome, yog tias muaj teeb meem insoluble.
Cov lus yooj yim ua rau muaj kev ua yuam kev, nws nyuaj rau txheeb xyuas qhov zoo ntawm hydroxypropyl methyl cellulose.Tam sim no nws yog feem ntau siv los ntsuas qhov viscosity ntawm cov viscometer teb, feem ntau siv hauv Suav teb.
Cov mis ntawm NDJ-1 viscometer yog η = Kα.η yog viscosity, kuj nyob rau hauv mpa.s, K yog tus coefficient ntawm viscometer, thiab α yog qhov kev nyeem ntawv ntawm viscometer pointer.
Hydroxypropyl methyl cellulose 2% viscosity test method:
1, txoj kev no yog tsim nyog rau kev txiav txim siab ntawm dynamic viscosity ntawm non-Newtonian kua (cov tshuaj polymer, ncua kev kawm ntawv, emulsion dispersion kua lossis surfactant, thiab lwm yam).
2. Cov cuab yeej thiab cov khoom siv
2.1 Rotary viscometer (NdJ-1 thiab NDJ-4 yog xav tau los ntawm Suav Pharmacopoeia)
2.2 Kev ntsuas kub tsis tu ncua dej da dej qhov ntsuas kub qhov tseeb 0.10C
2.3 Qhov ntsuas kub ntawm qhov ntsuas kub yog 0.20C, uas tau txheeb xyuas ib ntus.
2.4 Zaus meter Viscometers siv zaus ntsuas ntsuas (xws li NDJ-1 thiab NDJ-4) yuav tsum tau tseg.Qhov tseeb ntawm 1%.A
8. Cov qauv Og tau raug ntsuas kom raug thiab muab tso rau hauv ib lub thawv qhuav, toned 400mL siab beaker.Ntxiv li 100mL ntawm 80-90 degree dej kub thiab do rau 10min cais
Ua tib zoo disperse, do thiab ntxiv dej txias rau 400mL nyob rau hauv tag nrho.Lub caij no, do tsis tu ncua rau 30min kom ua 2% (W / W) tov, thiab muab tso rau hauv lub tub yees rau cov dej khov da dej kom txias kom txog thaum cov dej khov nyias nyias ntawm qhov chaw.
Tshem tawm thiab muab tso rau hauv lub tank kub tas li kom lub hauv paus kub txog 20 ℃ 0.1 ℃.
3.1 Kev teeb tsa thiab kev ua haujlwm ntawm lub cuab yeej yuav tsum tau ua raws li cov lus qhia ua haujlwm ntawm lub cuab yeej, thiab cov rotor thiab rotor tsim nyog yuav tsum raug xaiv raws li qhov viscosity ntau ntawm cov khoom kuaj thiab cov kev cai ntawm cov tshuaj pharmacopoeia raws li cov ntawv nyeem. khoom
Kev sib hloov ceev.
3.2 Kho qhov ntsuas kub tsis tu ncua dej raws li qhov kev txiav txim hauv qab txhua yam tshuaj.
3.3 Cov khoom kuaj tau muab tso rau hauv lub thawv uas tau teev tseg los ntawm qhov ntsuas, thiab lub kaum sab xis deflection (a) raug ntsuas raws li txoj cai tom qab 30 feeb ntawm qhov kub thiab txias.Tua lub cev muaj zog thiab rov pib dua rau kev txiav txim ib zaug ntxiv
Qhov sib txawv ntawm qhov nruab nrab qhov tseem ceeb yuav tsum tsis pub tshaj 3%, txwv tsis pub yuav tsum tau ua qhov ntsuas thib peb.
3.4 Xam tus nqi nruab nrab ntawm ob qhov kev xeem raws li cov qauv kom tau txais cov viscosity dynamic ntawm cov khoom kuaj.
4. Sau thiab xam
4.1 Sau cov qauv viscometer rotary, rotor naj npawb thiab ceev siv, viscometer tas li (K 'tus nqi), ntsuas kub, thiab txhua qhov ntsuas.Tus nqi.
Tus lej lej ntawm 4.2
Dynamic viscosity (MPa"s) = Ka qhov twg K yog lub viscometer tas li ntsuas nrog tus qauv kua ntawm paub viscosity thiab A yog lub kaum sab xis deflection
Post lub sij hawm: May-18-2022