Kws tsim kho cov neeg siv tau yog expients thiab ntxiv siv hauv kev tsim cov tshuaj thiab cov tshuaj, thiab yog ib feem tseem ceeb ntawm kev npaj tshuaj. Raws li lub ntuj polymer muab cov khoom siv, cellulose ether yog biodebrose, hydrox cellulose cellulose, hydulco cellulose, cellulropyl cellulose, hydulco cellulose, cellulropyl cellulose, cellulropy cellulose, Tam sim no, cov khoom lag luam ntawm cov xov tooj ntawm cov xov tooj etheric feem ntau yog siv rau hauv nruab nrab thiab qis-kawg ntawm kev lag luam, thiab tus nqi ntxiv tsis yog. Kev lag luam ceev xav tau kev hloov pauv thiab kev hloov kho tshiab los txhim kho cov ntawv thov siab kawg ntawm cov khoom lag luam.
Kev ua lag luam muaj peev xwm ntawm cov tshuaj kom zoo yog loj
Kws tsim kho cov tshuaj kom zoo nkauj ua lub luag haujlwm tseem ceeb hauv kev txhim kho thiab kev tsim cov qauv ntawm cov qauv. Piv txwv li, hauv kev npaj tawm-tso tawm, polymer cov tshuaj ete exhetections, ntau yam kev tso tawm cov tshuaj tua hluav taws, thiab cov ntawv tso cai tshuaj-tso tawm. Npaj thiab ua kua ua kom tiav-tso tawm tau siv dav. Hauv cov kab ke no, cov polymers xws li cellulose ether yog feem ntau siv cov neeg nqa tshuaj hauv tib neeg lub cev, yog tias nws yuav tsum tso tawm hauv lub cev tso tawm nyob rau hauv ib lub sijhawm ua tiav lub hom phiaj ntawm kev kho mob.
Raws li kev txheeb cais ntawm Zhiyan Kev Pab Tswv Yim Sab Laj Kev Lom Zem uas tau sau tseg nrog Tebchaws Meskas (ntau dua 1,000 hom sib txawv, thiab cov hom tseem tsawg. Kev txhim kho lub peev xwm ntawm kev ua lag luam yog loj heev. Nws tau to taub tias lub kaum lub cev tsim nyog nyob rau hauv kuv lub teb chaws kev ua lag luam, PvP, MicrocrystallE Cov neeg tsis noj nqaij, HPC, Lactose.
Rau Lub Tshuaj Tshuaj Saib Xyuas Cov Cellulose Ethere
Ntuj cellulose ether yog ib lo lus dav dav rau cov tshuaj tiv thaiv cellulose tsim los ntawm cov tshuaj tiv thaiv ntawm alkali cellulose thiab tus sawv cev rau qee yam. Nws yog cov khoom lag luam uas cov pawg hydroxyl ntawm cellulose macromolecules yog ib nrab lossis pab pawg ether. Cellulose Cov neeg muaj kev hais ua ke tau siv dav hauv cov roj av, cov khoom siv hauv tsev, cov khoom siv, tshuaj, thiab tshuaj txhua hnub. Hauv ntau thaj teb, cov khoom-cov khoom-cov khoom-cov khoom siv yog nyob rau hauv nruab nrab thiab qib siab ntawm kev lag luam, nrog tus nqi loj. Vim tias nruj ua tau zoo, kev tsim cov tshuaj-qib cellulose ether kuj nyuaj. Nws tuaj yeem hais tias qhov zoo ntawm cov tshuaj-cov khoom lag luam muaj peev xwm sawv cev lub zog ntawm cellulose enterprises. Cellulose ether yog feem ntau ntxiv ua ib qho blocker, pattricle cov ntaub ntawv, ruaj khov cov ntaub ntawv, kev tso cov ntaub ntawv ua yeeb yaj kiab, thiab lwm yam.
Sodium carboxymethyl cellulose
Carboxymethyl cellulose sodium (CMC-NA) yog lub cellulose ether nrog ntau qhov ntau tshaj plaws thiab noj hauv tsev thiab noj nyob txawv teb chaws thiab noj nyob txawv tebchaws. Nws yog Ionic cellulose ither ua los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos thiab etherical nrog chloroacetic acid. CMC-NA yog ib feem uas siv cov kws tshuaj kom zoo. Nws yog feem ntau siv los ua binder rau kev npaj khoom, thickening-ncos rau kev npaj kua, thiab nws kuj tseem tuaj yeem siv ua cov khoom siv dej-solrix thiab cov khoom siv ua yeeb yaj kiab. Nws yog feem ntau siv raws li kev tso tawm cov tshuaj yeeb yaj kiab thiab cov ntsiav tshuaj soapained-tso tawm cov ntsiav tshuaj (tswj) tso tawm.
Ntxiv rau sodium carboxymethylcellose raws li cov tshuaj uas muaj kev zam, soccarmellose sodium kuj tseem tuaj yeem siv los ua cov tshuaj uas muaj kev zam. Croscarmellose sodium (CCMC-NA) yog dej-insoluble cov khoom ntawm Carboxymelylcelleculose tus neeg saib xyuas ntawm qhov kev txiav txim siab (40-80 ° catalganic acid catalanst thiab lim. Raws li tus neeg sawv cev hla, propylene glycol, succinic anhydride, txiv neej anhydride thiab adipic anhydride yuav siv tau. Croscarmellose sodium yog siv los ua ib tug neeg ua txhaum rau cov ntsiav tshuaj, tsiav tshuaj thiab granules hauv kev npaj rau qhov ncauj. Nws tso siab rau capillary thiab offecting cuam tshuam rau kev tawg. Nws muaj cov kev hloov pauv zoo thiab muaj zog sib cav sib ceg. Cov kev tshawb fawb tau pom tias qhov ourge ntawm cov dej qab zib hauv dej yog ntau dua li cov neeg tsis sib haum xeeb xws li cov pa roj hmab tsawg dua li cov me me cellulose.
Methylcellulose
Methyl Cellulose (MC) yog cov tsis-ionic cellulose ib ionyl los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos thiab methyl cettication ethermication. Methylcellulose muaj cov dej ua dej zoo heev thiab ruaj khov nyob rau hauv ntau hom PH2.0 ~ 13.0. Nws yog dav siv nyob rau hauv cov tshuaj uas zoo siab, thiab yog siv nyob rau hauv cov ntsiav tshuaj subloft, intramuscular kev npaj, kev tshem tawm qhov ncauj, tshem tawm qhov ncauj, cov ntsiav tshuaj thiab kev npaj cov ncauj. Tsis tas li ntawd, hauv kev npaj kom muaj kev npaj cia, MC tuaj yeem siv los ua cov ntaub ntawv npaj ua kom hydrix soluble
Hydroxypropyloosylcelleculose
HydroxyPropyyl Metylcellulose (HPMC) yog qhov tsis-ionic cellulose sib xyaw los ntawm cov paj rwb thiab ntoo los ntawm cov pa roj hmab thiab methyl cettication ethermication. Nws yog tsis muaj ntxhiab, cov tsis tau, tsis muaj tshuaj lom, soluble hauv dej txias thiab gelled nyob rau hauv dej kub. HydroxyPropylencellulose yog lub cellulose sib xyaw ether ntau yam uas muaj ntau yam, thiab kev ua tau zoo tau sai sai nyob hauv Suav teb tau 15 xyoo dhau los. Nws tseem yog ib qho ntawm feem ntau dav siv cov tshuaj uas tau khaws cia hauv tsev thiab txawv teb chaws. xyoo keeb kwm. Tam sim no, daim ntawv thov ntawm HPMC yog xav tau nyob rau hauv tsib yam hauv qab no:
Ib qho yog ib phau ntawv sau thiab tsis sib haum. Raws li cov phau ntawv, HPMC tuaj yeem ua kom cov tshuaj yooj yim ntub dej, thiab nws tuaj yeem txhim kho cov dej, yog li nws tuaj yeem txhim kho cov kev cais tawm lossis tso tawm tus nqi ntawm cov ntsiav tshuaj. HPMC muaj cov viscosity muaj zog, uas tuaj yeem txhim kho cov particle viscosity thiab txhim kho lub tshuab nias ntawm cov ntaub ntawv nyoos nrog cov ntaub ntawv loj lossis cov ntxhib lossis nkig. HPMC nrog cov viscosity qis tuaj yeem siv tau los ua binder thiab ua tsis taus, thiab cov uas muaj viscosity siab tuaj yeem siv ua phau binder.
Qhov thib ob yog raws li kev txhawb nqa thiab tswj cov khoom tso tawm rau qhov ncauj npaj. HPMC yog ib feem siv hydrogel matrix cov khoom nyob rau hauv kev tsim txom-tso tawm. Cov qib qis-viscosity (5-30MC tuaj yeem siv tau los npaj cov khoom siv sib xyaw, thiab qib siab ntawm cov ntsiav tshuaj, hydrophilic gel Matrix cov ntsiav tshuaj ruaj khov-tso tawm. HPMC yog soluble nyob rau hauv cov kua roj plab, muaj qhov zoo ntawm kev ua kom zoo nkauj zoo, cov tshuaj zoo, thiab siv tshuaj yeeb yam muaj cuam tshuam los ntawm ph. Nws yog ib qho tseem ceeb heev hydrophilic cov khoom siv hydrophilic cov khoom siv hauv kev npaj cov tshuab thiab cov khoom npaj rau cov pa roj av npaj tshuaj thiab kev tso tshuaj yeeb yaj kiab.
Qhov thib peb yog raws li txheej xim yeeb yaj kiab-ua tus neeg sawv cev. HPMC muaj cov yeeb yaj kiab zoo-tsim cov khoom. Zaj duab xis tsim los ntawm nws yog yam tsis zoo, pob tshab thiab tawv, thiab nws tsis yooj yim rau lo rau lub sijhawm ntau lawm thaum tsim khoom. Tshwj xeeb tshaj yog rau cov tshuaj uas tau yooj yim nqus noo noo thiab tsis ruaj khov, siv nws ua kev sib cais ntawm cov tshuaj thiab tiv thaiv cov yeeb yaj kiab hloov xim. HPMC muaj ntau yam viscosity specifications. Yog tias xaiv tau zoo, qhov zoo thiab pom ntawm coated ntsiav tshuaj yog qhov zoo dua rau lwm cov ntaub ntawv. Cov kev siv ntau zaus yog 2% rau 10%.
Plaub yog cov tshuaj ntsiav capsule. Nyob rau hauv xyoo tsis ntev los no, nrog cov kab mob nquag ntawm ntiaj teb cov tsiaj kab mob, piv nrog gelatin tsiav tshuaj, zaub tsiav tshuaj tau dhau los ua tus tshiab ntawm cov tshuaj thiab khoom noj khoom haus. Pfizer ntawm Tebchaws Meskas tau ua tiav HPMC los ntawm cov nroj tsuag ntuj thiab npaj vcaptm zaub capsules. Piv nrog tsoos gelatin hollow cafsules, tsob nroj clotules muaj qhov zoo ntawm kev yoog raws kev sib txuas lus dav dav thiab kev ruaj khov. Tus nqi tso tawm Yeeb Tshuaj yog qhov sib txawv, thiab qhov sib txawv yog me me. Tom qab ua kom tsis tu ncua nyob rau hauv tib neeg lub cev, nws tsis yog nqus thiab tuaj yeem raug cais tawm cov tshuaj tau tawm ntawm lub cev. Hais txog kev cia xwm txheej, tom qab muaj ntau ntawm cov kev ntsuam xyuas, nws yuav luag tsis yog ruaj khov nyob rau hauv cov cantsule tsis muaj kev mob tsis muaj kev cuam tshuam nyob rau hauv huab cua cia. Nrog tib neeg to taub cov nroj tsuag tsiav tshuaj thiab kev hloov pauv ntawm cov tswv yim pej xeem hauv tsev hauv tsev thiab txawv teb chaws rau cov tshuaj ntsiav yuav loj hlob sai.
Thib tsib yog raws li kev ncua tus neeg sawv cev. Ncua-hom kua npaj yog ib qho kev siv tshuaj kho mob feem ntau, uas yog cov tshuaj tsis muaj tshuaj tiv thaiv cov tshuaj tsis sib xws rau hauv cov kua rho tawm. Qhov kev ruaj ntseg ntawm lub system txiav txim siab qhov zoo ntawm kev npaj ua kua ncua. HPMC colloidal kev daws teeb meem yuav txo cov kua-kua interfacial nro, txo cov khoom qab zib dawb ntawm cov khoom, thiab ruaj khov lub heterogeneous system. Nws yog ib tug neeg sawv cev ua tau zoo tshaj plaws. HPMC yog siv los ua cov tuab rau cov tee qhov muag, nrog cov ntsiab lus ntawm 0.45% rau 1.0%.
HydroxyPropyl cellulose
HydroxyPropyl cellulose (HPC) yog ib qho tsis-ionic cellulose ib ionic ua los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos thiab propylene oxide ethermov. HPC feem ntau soluble nyob rau hauv dej qis dua 40 ° C thiab ntau cov kuab tshuaj polar, thiab nws cov kev ua tau zoo muaj feem xyuam rau cov ntsiab lus ntawm hydroxypropyl thiab cov qib ntawm polymerization. HPC tuaj yeem sib haum nrog ntau yam tshuaj thiab muaj cov inertia zoo.
Tsawg-hloov hydroxyprropyl cellulose (L-HPC) tsuas yog siv los hloov cov ntsiav tshuaj ua tsis cais thiab phau ntawv. -HPC tuaj yeem txhim kho lub hardness thiab ci ntsa iab ntawm cov ntsiav tshuaj, thiab tseem tuaj yeem ua kom cov ntsiav tshuaj tau ua rau lub ntsiav tshuaj disintegrate sai, thiab txhim kho cov txiaj ntsig curative.
Zoo hloov hydroxyprropyl cellulose (H-HPC) tuaj yeem siv ua phau ntawv rau cov ntsiav tshuaj, granules, thiab zoo heev granules nyob rau hauv lub chaw tshuaj. HPC muaj cov yeeb yaj kiab zoo tshaj plaws, thiab cov yeeb yaj kiab tau nyuaj thiab ywj, uas tuaj yeem piv nrog cov tshuab yas. Cov kev ua yeeb yam ntawm zaj duab xis tuaj yeem txhim kho txuas ntxiv los ntawm kev sib xyaw nrog lwm cov chaw ua si noo noo, thiab nws feem ntau siv ua cov khoom siv ua ntej rau cov ntsiav tshuaj rau cov ntsiav tshuaj. HPC HPC kuj tseem siv tau los ua cov khoom sib dhos los npaj cov ntsiav tshuaj, kev tso tawm cov pob tw thiab cov txheej txheem ob npaug.
Hydroxyethyl cellulose
Hydroxyethyl cellulose (HEC) yog ib qho tsis-ionic cellulose ib ionhat los ntawm paj rwb thiab ntoo los ntawm kev saib xyuas thiab ethylene oxide. Hauv thaj chaw ntawm cov tshuaj, HEC feem ntau yog siv los ua tuab, tshuaj nplaum, cov tshuaj nplaum, cov ntsiav tshuaj, cov ntsiav tshuaj, tshuaj ntsiav thiab lwm cov ntaub ntawv ntau npaum li cas. Hydroxyethyl cellulose tau raug kaw hauv Asmeskas Pharmacopoeia / US National Sormulary thiab cov kws tshuaj hauv European thiab European Pharpacopoeia, thiab lwm yam.
Ethyl Cellulose
Ethyl cellulose (EC) yog ib qho ntawm feem ntau dav siv dej-insoluble cellulose derivget. EC yog tsis muaj tshuaj lom, ruaj khov, insoluble hauv dej, kua qaub lossis alkali, thiab soluble hauv cov kuab tshuaj ethanol thiab methanol. Feem ntau siv cov kuab tshuaj yog toluene / ethanol li 4/1 (qhov hnyav) sib xyaw kuab. EC muaj ntau yam siv hauv kev npaj tshuaj yeeb yaj kiab, xws li cov ntaub ntawv sib xyaw ua ke, thiab cov duab dhos ua yeeb yaj kiab, thiab cov yeeb yaj kiab sib xyaw los npaj cov tshuaj lom neeg, thiab cov khoom siv ua ke los npaj cov tshuaj lom neeg, thiab kev tso tawm cov pellets, siv raws li encapsulation cov ntaub ntawv los npaj kev siv cov microcapsules; Nws kuj tseem tuaj yeem siv dav siv ua cov khoom siv cov khoom siv rau kev npaj ntawm cov khoom tawg; Dav siv hauv cov tshuaj thev naus laus zis uas yog kev ua yeeb yaj kiab yeeb yaj kiab thiab kev tiv thaiv kev tiv thaiv, nrog rau cov binder thiab muab tub lim. Raws li kev tiv thaiv txheej ntawm cov ntsiav tshuaj, nws tuaj yeem txo cov kev rhiab ntawm cov ntsiav tshuaj rau cov av noo thiab tiv thaiv cov tshuaj los ntawm kev cuam tshuam los ntawm kev noo noo, tshem tawm thiab tsis zoo; Nws kuj tseem tuaj yeem ua cov txheej gel qeeb-tso tawm, microencapaprate cov polymer, thiab pab txhawb kom cov tshuaj cuam tshuam ntawm cov tshuaj.
Tau tshem tawm ntawm cov ntawv thov qis qis thiab ua kom nrawm nrawm thiab hloov kho tshiab
Hauv cov ntsiab lus, dej-soluble sodium carboxymethyl cellulose, hydrox cellule, pab txhawb nqa cov ntaub ntawv ntawm lub cev, txhawb nqa cov ntaub ntawv tso tawm, hydroxyin cellulose Cov neeg sawv cev, tshuaj ntsiav tshuaj thiab cov neeg sawv cev tsis tuaj yeem. Saib rau hauv lub ntiaj teb, muaj ntau cov tuam txhab ua lag luam txawv teb chaws (shin-etsu Nyij pooj Daim ntawv thov tawm tswv yim hauv. Dow Wolfe tshaj tawm tias nws yuav ntxiv dag zog rau nws lub siab xav ua lag luam, cov khoom siv thov tshuaj, thiab nws cov cuab yeej tshawb fawb yuav siv zog kom txav ze rau kev ua lag luam. Dow tshuaj Wold Cellulose faib thiab xim Corporation ntawm Tebchaws Asmeskas tau tsim cov kws tshaj lij thoob ntiaj teb, muaj ntau cov neeg ua haujlwm tshawb nrhiav cov kws tshawb fawb hauv kwv yees li 160 lub teb chaws. Ashland muaj cov hauv paus ntau lawm hauv Beijing, Tianjin, Nanjie, Changzhou, Chanpshan thiab tau nqis peev rau peb cov chaw tshawb fawb hauv Shanghai thiab Nanjing.
Raws li kev txheeb cais los ntawm lub vev xaib cellulose koom haum, nyob rau xyoo 2017, lub tsev cellulose ether yog 373,000 tons, thiab ntim ntim yog 360,000 tons. Hauv 2017, qhov muag tiag tiag muag ntim ntawm Ionic CMC yog 234,000 tons, nce ntxiv ntawm 18.61% xyoo ntawm-ionic CMC yog 126,000 tons, nce ntxiv 8.2% thawm xyoo. Ntxiv rau HPMC (tsev cov khoom siv qib), cov khoom lag luam HPM), HPMC (HPC (CareC (HITCRArcing cov qauv thiab lawv cov khoom lag luam thiab muag khoom tau txuas ntxiv ntxiv. Cov cellulic ether tau loj hlob sai rau ntau tshaj kaum xyoo, thiab nws cov zis tau dhau los ua thawj hauv ntiaj teb. Txawm li cas los xij, cov khoom ntawm feem ntau cellulose ether cov tuam txhab yog tsuas yog siv nyob rau hauv nruab nrab thiab qis-kawg teb ntawm kev lag luam, thiab ntxiv tus nqi tsis siab.
Tam sim no, feem ntau hauv cellule cellulose ether cov kev lag luam yog nyob rau hauv lub sijhawm tseem ceeb ntawm kev hloov pauv thiab txhim kho. Lawv yuav tsum txuas ntxiv kev tshawb nrhiav cov khoom lag luam thiab kev tsim kho cov khoom lag luam hauv ntiaj teb, thiab ua tiav cov kev lag luam thoob ntiaj teb, thiab ua tiav benign thiab ntsuab kev loj hlob.
Lub Sijhawm Post: Jun-15-2023