Kws tsim kho cov neeg siv tau yog excipients thiab adjuncts siv hauv kev tsim khoom thiab dispensing ntawm cov tshuaj, thiab yog ib feem tseem ceeb ntawm kev npaj tshuaj. Cellulose ether as derived from natural polymer material, has the characteristics of biodegradable, nontoxic, cheap, such as sodium carboxymethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethyl cellulose and hydroxyethyl cellulose, cellulose ether has important application value in the pharmaceutical excipients. Tam sim no, feem ntau ntawm cov khoom ntawm cellulose cellulose feem ntau yog siv nyiaj ntau dua, txhim kho kev hloov kho tshiab, txhim kho cov ntawv thov siab kawg.
Kws Tshuaj Ntsuam Xyuas Kev Lag Luam Muaj Peev Xwm Muaj Peev Xwm Loj
Kws tsim kho cov tshuaj ua si yog lub luag haujlwm tseem ceeb hauv kev txhim kho thiab kev tsim khoom ntawm cov kws tshuaj. Piv txwv li, hauv kev npaj tawm-tso tawm, cov khoom siv hluav taws xob, cov khoom siv hluav taws xob uas tau tso tawm, cov khoom siv hluav taws xob tau npaj tseg, cov khoom siv hluav taws xob tau raug tshem tawm, cov khoom siv hluav taws xob tau raug tshem tawm thiab cov khoom siv ua kua kom zoo. Hauv cov kab ke no, cellulose ether thiab lwm cov neeg ua yeeb yam ntawm cov tshuaj ntawm cov neeg tso tawm hauv lub sijhawm tso tawm hauv lub sijhawm ua haujlwm.
Raws li cov txheeb cais ntawm Zhiyan kev sab laj thiab cov chaw tshawb fawb, tab sis piv rau Tebchaws Asmeskas, muaj ntau dua li 3000 tshaj li 3000 dua li cov chaw tsim khoom lag luam muaj peev xwm loj heev. Nws tau to taub tias sab saum toj ntawm cov tshuaj uas muaj kev cia siab hauv Suav teb yog cov hmoov txhuv nplej siab, 1, duab plaub hau, microcrystalline cellulose, HPC, LACTOSE.
RauHom ntawmCellulose etherhauvKws Tshuaj Xyuas
Ntuj cellulose ether yog alkali cellulose thiab eretecting pawg neeg ethoth ether olds yog ib nrab lossis hloov tag nrho los ntawm cov khoom. Cellulose ether yog dav siv nyob rau hauv cov roj av, cov khoom siv, tshuaj noj, khoom noj txhua hnub, hauv txhua qhov chaw siab nyob hauv kev lag luam siab, nrog tus nqi siab. Vim tias nruj ua tau zoo, kev tsim cov tshuaj cellulectical ether kuj nyuaj, nws tuaj yeem hais tau lub zog ntawm cov tshuaj ntawm cellulose ether cov lag luam. Cellulose ether feem ntau yog siv los ua kev thaiv, cov khoom siv pob txha, ua los ntawm kev tso tawm pob txha, ua los ntawm kev tso tawm cov ntaub ntawv ntim cov khoom,
Sodium carboxymethyl cellulose
Sodium Carboxymethyl cellulose (CMC-NA) yog ntau ntau yam kua txiv, yog cov txheej txheem ua los ntawm cov ionic cellulose ether. CMC-NA yog ib hom kev siv tshuaj uas nquag siv, siv cov khoom ua kua rau kev npaj khoom siv rau kev npaj ua kua, nrog rau dej-soluble matrix thiab zaj duab xis ua cov ntaub ntawv. Nyob rau hauv qeeb (tswj) tso tawm kev npaj, nws feem ntau siv ua zaj duab xis tus neeg sawv cev rau kev tso tshuaj qeeb tawm.
Ntxiv rau sodium carboxymethyl cellulose raws li cov khoom siv charmings, crosslinked sodium carboxymethyl cellulose kuj tseem siv tau raws li cov tshuaj uas tau siv. Crosslinked sodium carboxymethyl cellulose (CCMC-NA) yog ib tug neeg tua hluav taws uas muaj qhov kub ntawm tus kheej (40 ℃) nyob rau hauv kev ua ntawm inorganic acid catalyst. Tus neeg sawv cev hla tuaj yeem yog propylene glycol, succinic anhydride, txiv neej monsic anhydride thiab adipic anhydride. Crosslinked sodium carboxymethyl cellulose yog siv los ua cov ntsiav tshuaj uas tsis sib xws, nws cov khoom siv hluav taws xob tsis sib haum, nws cov khoom siv hluav taws xob zoo, muaj zog disintegrating. Cov kev tshawb fawb tau qhia tias qhov o degree ntawm crosslinked sodium carboxymethyl cellulose thiab lwm yam kev sib cais cov neeg sawv cev.
Methyl Cellulose
Methyl Cellulose (MC) yog ib qho kev ua haujlwm ntawm lub cev ntawm lub cev ether los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos, chloromethane ethermau thiab lwm yam txheej txheem. Methyl cellulose muaj cov dej ua dej zoo heev thiab ruaj khov hauv phua ntawm 2.0 ~ 13.0. Nws yog dav siv nyob rau hauv cov tshuaj uas muaj kev cia siab, cov ntsiav tshuaj submingual, intramuscular txhaj tshuaj, tshem tawm cov ntsiav tshuaj, cov ntsiav tshuaj, cov ntsiav tshuaj thiab npaj hauv zos. Ib qho ntxiv, MC tuaj yeem siv los ua Hydrophilic Gel moj khaum-tso tawm cov khoom siv, txhawb nqa cov khoom siv los ntawm cov khoom siv, thiab lwm yam.
HydroxyPropyyl Methyl cellulose
HydroxyPropy cellulose (HPMC) yog cov kev sib xyaw ntawm cov paj ntaub los ntawm cov paj rwb thiab ntoo los ntawm cov paj rwb thiab cov tshuaj pleev cov tshuaj pleev thiab tshuaj pov tseg. Nws yog tsis muaj ntxhiab, cov tsis tau pom thiab tsis muaj tshuaj lom, soluble hauv dej txias thiab gelatinous nyob rau hauv dej kub. HydroxyPropy cellulose yog cov txiaj ntsig hauv tsev yog qhov muaj txiaj ntsig zoo, yog ib qho ntawm cov tshuaj txawv txawv, yog ib qho ntawm kev paub txog kev zam tau muaj ze li 50 xyoo ntawm keeb kwm. Ntawm tam sim no, HPMC daim ntawv thov yog feem ntau los ntawm tsib yam:
Ib qho yog ib phau ntawv sau thiab cov neeg sawv cev tsis sib haum. HPMC ua phau ntawv yuav ua rau cov tshuaj yooj yim ntub, thiab nws cov dej tuaj yeem txhim kho ntau zaus, yog li nws tuaj yeem txhim kho cov duab lossis tso cov ntsiav tshuaj. HPMC muaj cov viscosity muaj zog, rau cov qauv viscosity, rau cov qauv viscosity, rau cov qauv ntawm cov ntaub ntawv raw tuaj yeem txhim kho nws cov particle viscosity, txhim kho nws cov kev hloov pauv. HPMC qis viscosity tuaj yeem siv los ua phau ntawv binder thiab disintegrating tus neeg sawv cev, siab viscosity tsuas yog ib phau.
Qhov thib ob yog qhov qeeb thiab tswj cov khoom tso tawm rau qhov ncauj npaj. HPMC yog lub moj khaum hydrographel cov khoom siv feem ntau siv nyob rau hauv kev tsim tawm-tso tawm. HPMC nrog qib viscosity qis (5 ~ 50mpa-oors, thaum HPMP nrog cov ntsiav tshuaj viscosity thiab hydroughilic gel moj khaum Sustained ntsiav tshuaj. HPMC tuaj yeem yaj nyob rau hauv cov kua roj plab, muaj cov khoom siv hydroughilic tsis muaj cuam tshuam, thiab siv cov pa hluav taws xob ua kom muaj kev cuam tshuam nrog kev npaj tshuaj expipients.
Thib peb, raws li txheej ua zaj duab xis - tsim tus neeg sawv cev. HPMC muaj zaj duab xis zoo, nws ua cov yeeb yaj kiab zoo nkauj, tshwj xeeb yog cov tshuaj tsis yooj yim tuaj yeem txhim kho kev ruaj ntseg ntawm cov tshuaj, tiv thaiv zaj yeeb yaj kiab yooj yim, tiv thaiv kev sib cais ntawm cov tshuaj, tiv thaiv zaj yeeb yaj kiab yooj yim. HPMC muaj ntau yam viscosity specifications, xws li kev xaiv kom tsim nyog, cov tsos ua yeeb yaj kiab zoo dua li lwm cov ntaub ntawv, nws feem ntau siv concentration ntawm 2% ~ 10%.
Plaub yog cov tshuaj capsule capsule. Nyob rau hauv xyoo tsis ntev los no, nrog kev nquag kis ntawm cov tsiaj txhu tsiaj thoob ntiaj teb, muab piv nrog cov tshuaj ntsuab, nroj tsuag capsules tau dhau los ua tus tshiab ntawm cov tshuaj thiab kev lag luam khoom noj khoom haus. Pfizer tau ua tiav HPMC los ntawm cov nroj tsuag ntuj thiab npaj vcaptm cog cov ntsiav tshuaj. Piv nrog cov tsoos gollatin hollow cafsules, tsob nroj cantsules muaj qhov zoo ntawm kev phiv ntau ntxiv thiab muaj kev ruaj khov. Tus nqi tso tawm Yeeb Tshuaj yog tus lej sib txawv, thiab lawv tsis tuaj yeem nqus tau tom qab lub cev sib cais, thiab tuaj yeem raug tshem tawm ntawm lub cev nrog quav. Hais txog kev cia xwm txheej, los ntawm ntau cov kev sim, cov tsiav tshuaj yuav luag tsis khov nyob hauv qab cov tshuaj maj mam ruaj khov, thiab cov ntsuas ntawm cov nroj tsuag muaj kev cuam tshuam tsis muaj kev cia siab. Nrog tib neeg txoj kev nkag siab ntawm cov nroj tsuag capsules, nrog rau kev hloov pauv ntawm pej xeem tshuaj hauv tsev thiab txawv teb chaws, kev lag luam kev xav tau ntawm cov nroj tsuag capsules yuav loj hlob sai.
Tsib yog raws li ib tug neeg sawv cev ncua. Raug tshem tawm ua kua npaj ua tiav yog siv nyob rau hauv chaw kuaj mob cov ntaub ntawv, uas yog heterogeneous cov ntaub ntawv ntawm insoluble cov tshuaj hauv cov kua ?? dispersion. Qhov ruaj khov ntawm lub system txiav txim siab qhov zoo ntawm kev npaj ua kua tsis raug. HPMC colloidal solution can reduce the solid-liquid interface tension, reduce the surface free energy of solid particles, so that the heterogeneous dispersion system tends to be stable, is an excellent suspension agent. HPMC yog siv los ua cov tuab ntawm cov tee qhov muag muag, thiab cov ntsiab lus yog 0.45% ~ 1.0%.
HydroxyPropyl cellulose
HydroxyPropyl cellulose (HPC) yog ib qho noticoleces ntawm lub cellulose ete los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos, propylene oxide etherification thiab lwm yam txheej txheem. HPC feem ntau soluble hauv dej qis dua 40 ℃ thiab ntau ntawm cov kuab tshuaj polar. Nws cov khoom yog cuam tshuam nrog cov ntsiab lus ntawm hydroxypropyl thiab qib ntawm polymerization. HPC tuaj yeem sib haum nrog ntau yam tshuaj thiab muaj cov inertia zoo.
Qiab hloov pauv hydroxyprropyl cellulose (L - HPC) feem ntau yog ua kom muaj zog, txhawb nqa kev ua kom zoo, txhawb nqa kev ua kom zoo, txhawb nqa kev ua kom zoo nkauj, txhawb nqa cov duab zoo nkauj, txhawb nqa cov duab zoo nkauj, thiab txhim kho cov txiaj ntsig curative.
Muaj kev hloov kho cellulropyl ntawm hydroxyprropyl cellulose (H-HPC) tuaj yeem siv los ua phau ntawv, granule thiab zoo granule hauv cov chaw tshuaj. HPC muaj cov yeeb yaj kiab zoo tshaj plaws ua vajtse, zaj duab xis tau yog tawv thiab ywj, thiab tuaj yeem piv nrog cov yas. Los ntawm kev sib xyaw nrog lwm cov tshuaj tiv thaiv noo noo, cov yeeb yaj kiab ua tau zoo ntxiv, thiab siv tau ua cov khoom siv ua yeeb yaj kiab rau cov ntsiav tshuaj. HPC HPC kuj tseem siv tau los ua cov moj khaum los npaj cov tshuaj lom neeg thiab cov txheej txheem sib dhos.
Hydroxyethyl cellulose
Hydroxyethyl cellulose (HEC) yog ib qho kev ua haujlwm ntawm lub cev ib qho los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos, ethylene oxide etherification thiab lwm yam txheej txheem. HEC feem ntau yog siv cov thickener, colloidal tiv thaiv tus neeg sawv cev, cov nplaum, khib lav, tus neeg siv tawv, sau zaj duab xis nyob hauv chav kho mob. Nws tuaj yeem siv tau hauv cov tshuaj pleev cov tshuaj hauv zos, tshuaj pleev, qhov muag ua kua, cov ntsiav tshuaj, ntsiav tshuaj, cov ntsiav tshuaj thiab lwm yam tshuaj noj. Hydroxyethyl cellulose tau suav nrog hauv Tebchaws Meskas Cov Tshuaj Tiv Thaiv Cov Tshuaj / United States cov chaw ua haujlwm thiab European Pharracopoia.
Ethyl Cellulose
Ethyl cellulose (EC) yog ib qho ntawm feem ntau dav siv dej-insoluble cellulose derivget. EC yog tsis muaj tshuaj lom thiab ruaj khov, insoluble hauv dej, kua qaub lossis alkali daws, soluble hauv ethanol, methanol thiab lwm yam kuab tshuaj organic. Cov kuab tshuaj uas tau toluene / ethanol sib xyaw ntawm 4/1 los ntawm qhov hnyav. EC muaj ntau siv cov tshuaj tswj-tso tawm cov khoom siv ntawm cov khoom sib xyaw, xws li cov khoom siv pob txha, siv cov ntaub ntawv sib xyaw, siv ua cov khoom siv qeeb Tso tawm micro capsule; Nws tseem tuaj yeem siv dav siv raws li cov khoom siv cov khoom siv los npaj cov khoom sib cais. Nws yog dav siv hauv cov tshuaj thev naus laus zis uas yog zaj duab xis tsim cov tshuaj yeeb thiab kev tiv thaiv, nrog rau cov binder thiab muab tub lim. Raws li kev tiv thaiv kev txiav tawm ntawm cov ntsiav tshuaj, nws tuaj yeem txo cov kev rhiab ntawm cov ntsiav tshuaj rau cov av noo thiab tiv thaiv cov tshuaj los ntawm kev cuam tshuam los ntawm damp thiab discoloration. Nws kuj tseem tuaj yeem ua cov txheej txheem maj mam muab tso tawm thiab encapsulate lub polymer nrog microcapsules, kom cov tshuaj siv tshuaj yuav muab tso ua txuas ntxiv.
Peb yuav tau tshem ntawm nruab nrab - thiab cov ntawv thov tsawg kawg thiab ua kom nrawm nrawm thiab hloov kho tshiab
Kom suav cov dej, cov dej soluble sodium, cov tshuaj all Kws tsim kho cov tshuaj. Saib lub ntiaj teb, ntau tus tuam txhab kev ua lag luam thoob ntiaj teb (Nyiv Shin-ETSU, Ntau Lawm, lossis nce ntxiv kev nqis peev hauv daim teb no. DoW tshaj tawm tias nws yuav nqis nws cov kev tsom xam rau cov qauv, cov khoom siv thiab kev siv zog los nqa cov kev tshawb fawb thov kom ze rau kev ua lag luam. Dow lub cellulose faib thiab xim tau tsim muaj cov Alliance thoob ntiaj teb rau cov neeg ua haujlwm tshawb fawb-cov neeg siv khoom muaj kwv yees li 160 lub teb chaws. Ashland muaj cov chaw tsim khoom hauv Beijing, Tianjin, Nanjhai, Chanshan thiab tau nqis peev pab peb cov tshuab tshuaj thev naus laus technology hauv Shanghai thiab Nanjing.
Raws li lub vev xaib ntawm Tuam Tshoj Cellulose ether etriation, nyob rau hauv 2017, lub dim detic ntawm cellulose ether yog 373,000 tons, thiab ntim ntim yog 360,000 tons. Hauv 2017, qhov muag tiag tiag muag ntim ntawm Ionic CMC yog 234,000 tons, nce 18.61% xyoo nyob rau xyoo, thiab ntawm tons, li 82% xyoo nyob rau xyoo. Cov khoom tsis yog-ionic ntxiv rau HPMC (HPMC (HPMC (FITCC (FEMCC (FEMCC (FITCC (FILDCT), HPMC (Khoom Noj) Cov kws tshaj lij hauv tsev ether tau loj hlob sai rau ntau tshaj kaum xyoo, tab sis feem ntau ntawm cov lag luam ether cov kev lag luam yog siv rau qhov tsawg-kawg ntawm kev lag luam, tus nqi ntxiv tsis yog.
Ntau yam cellulose ether qhauj hauv tsev thiab txawv teb chaws, feem ntau yuav ua tiav cov khoom lag luam txawv teb chaws, ua kom muaj kev txhim kho hauv ntiaj teb, kom paub txog kev hloov kho hauv ntiaj teb, paub txog tus cwjpwm thiab kev txhim kho benign thiab kev loj hlob ntsuab.
Lub Sijhawm Post: Jan-27-2022