HydroxyPropyyl methylulose (HPMC) thiab methylcellulose (MC) yog ob daim ntawv thov celluligent siv hauv cov ntawv thov tshuaj vim lawv cov khoom siv ntau yam. Txawm hais tias lawv zoo sib xws, lawv muaj qhov sib txawv hauv cov qauv tshuaj lom neeg, cov khoom, thiab cov ntawv thov uas ua rau lawv haum rau cov laj thawj ntawm kws tshuaj.
Tshuaj lom neeg muaj pes tsawg leeg thiab cov qauv
HydroxyPropyyl methylcellulose (HPMC):
HPMC yog kev hloov kho lub cev hloov cellulose ether. Nws yog muab los ntawm cellulose los ntawm kho nws cov tshuaj methyl chloride thiab probylene oxide, -ch2chopropyl (-ch2chohch3) pab pawg mus rau hauv lub cellulose cellebone. Cov qib degree hloov pauv (DS) thiab cov hniav puas hloov (MS) txiav txim siab ntawm cov pab pawg no. DS sawv cev rau cov pawg nruab nrab ntawm cov pawg hydroxyl hloov ib pawg ntawm cov pawg uas muaj pob zeb ntawm cov neeg hydroxyprropylopyl txuas.
Methylcellulose (MC):
MC yog lwm tus cellulose ether, tab sis nws tau hloov kho dua li HPMC. Nws yog tsim los ntawm kev kho cellulose nrog methyl chloride, ua rau hloov chaw ntawm cov pab pawg hydroxyl nrog cov pab pawg meTOXY. Qhov kev hloov kho no tau muaj nuj nqis los ntawm qib degree (ds), uas, rau MC, feem ntau yog li ntawm 1.3 txog 2.6. Tsis muaj cov pab pawg hydroxypropyl hauv Mc cais nws los ntawm HPMC.
Cov Khoom Siv Lub Cev
Solubility thiab gelation:
HPMC yog soluble hauv ob qho tib si txias thiab dej kub, sib sau cov tshuaj colloidal. Thaum muaj cua sov, HPMC undergoribersible thermoreversible gelation, lub ntsiab lus nws sau ib gel thaum rhuab thiab rov qab rau kev daws thaum txias. Cov cuab yeej no yog pab tau tshwj xeeb rau hauv kev tswj tshuaj yeeb thiab raws li viscosity enhancer hauv cov kev daws teeb meem aqueous.
MC, ntawm qhov tod tes, yog soluble hauv dej txias tab sis insoluble hauv dej kub. Nws tseem ua kom cov thermogelation; Txawm li cas los xij, nws gelation kub feem ntau qis dua li HPMC. Cov xeeb ceem no ua rau MC Tsim nyog rau cov ntawv thov cov tshuaj ntawm qhov chaw qis dua gelation kub yog qhov zoo.
Viscosity:
Ob tus HPMC thiab MC tuaj yeem nce cov tshuaj viscosity ntawm cov kua aqueous, tab sis HPMC feem ntau muaj cov viscosities ntau vim yog nws cov qauv hloov chaw. Qhov kev hloov pauv no pub rau ntau txoj kev tswj hwm hauv cov qauv tsim qauv uas xav tau cov viscosity profiles.
Kev ua haujlwm nyob rau hauv cov kws tshuaj
HPMC:
Tshuaj Nplaum Reling Matrix formated:
HPMC muaj kev siv dav dav hauv kev tswj cov khoom tso tawm sib npaug. Nws lub peev xwm mus rau o thiab tsim cov txheej txheem gel thaum muaj cov kua plab yuav pab nrog kev tswj cov tshuaj tso tawm. Cov gel txheej ua raws li kev thaiv, modulating solfusion ntawm cov tshuaj thiab txuas nws tso tawm.
Zaj duab xis txheej:
Vim nws cov yeeb yaj kiab zoo tshaj plaws, HPMC tau dav siv nyob rau hauv cov txheej ntawm cov ntsiav tshuaj thiab pellets. Nws muab kev tiv thaiv tiv thaiv kev ya raws, oxygen, thiab lub teeb, txhim kho lub neej ruaj khov thiab lub neej txee ntawm cov khoom. Ib qho ntxiv, HPMC txheej tuaj yeem siv rau saj daim npog ntsej muag thiab txhawm rau txhim kho cov ntsiav tshuaj ntawm cov ntsiav tshuaj.
Binder nyob rau hauv cov ntsiav tshuaj tsim:
HPMC kuj tseem ua haujlwm yog ib phau ntawv tuav hauv cov txheej txheem ntub cov txheej txheem. Nws ua kom cov neeg kho tshuab lub zog ntawm cov ntsiav tshuaj, muab txoj hlua khi ntawm cov hmoov uas muaj hmoov av thaum lub sijhawm compression.
Ncua thiab cov neeg saib xyuas ntub dej:
Hauv cov kua tsim ua kua, HPMC ua haujlwm raws li kev ncua thiab cov neeg saib xyuas tuab. Nws cov viscosity siab pab ua kom tswj cov kev faib tawm ntawm cov khoom sib txuam ntawm cov hais uas tau muab ncua thiab txhim kho kev sib xws ntawm cov qauv.
MC:
Ntsiav Tshuaj Ntsiav Tshuaj:
MC siv los ua phau ntawv sau ua hauv ntsiav tshuaj. Nws muab cov khoom siv khi zoo thiab lub zog kho tshuab rau cov ntsiav tshuaj, ua kom lawv txoj kev ncaj ncees thaum tuav thiab khaws cia.
Dismintegrant:
Muaj qee kis, MC tuaj yeem ua haujlwm ua kev tsis sib haum, pab cov ntsiav tshuaj kom tawg ua kom tawg me me thaum sib chwv nrog cov pa roj plab, yog li yooj yim tshuaj yeeb.
Cov Qauv Tso Tawm:
Txawm hais tias tsawg dua HPMC, MC tuaj yeem siv hauv kev tswj hwm kev tso tawm. Nws cov cua ntau zog ua rau muaj peev xwm siv tau los tswj cov ntawv tso tawm ntawm cov yeeb tshuaj.
Thickening thiab ruaj khov saib:
MC tabtom siv raws li lub thickening thiab ruaj khov nyob rau hauv ntau yam kua thiab ib nrab ua qauv tsim qauv. Nws lub peev xwm los nce viscosity pab rau hauv kev tswj hwm qhov ruaj ntseg thiab homogeneity ntawm cov khoom.
Cov ntawv thov tshwj xeeb hauv Pharpineuticals
HPMC daim ntawv thov:
Ophthalmic npaj:
HPMC yog nquag siv nyob rau hauv ophthalmic daws thiab gels vim nws lubricating thiab Viscoelastic khoom. Nws muab cov dej noo khaws thiab prolongs lub sijhawm hu rau ntawm cov tshuaj nrog sab hauv.
Transdermal Cov Tshuab:
HPMC tau ua haujlwm hauv kev hloov pauv thaj uas nws cov yeeb yaj kiab ua yeeb yaj kiab uas nws cov yeeb yaj kiab ua ke pab hauv kev tsim cov tshuaj tswj tso tawm rau kev xa cov tshuaj los ntawm daim tawv nqaij.
Mucoadhesive Tsim:
Cov mucoadhesive thaj chaw ntawm HPMC ua rau nws haum rau buccal, Nasal, thiab lub sijhawm siv tshuaj Veecal, txhim kho lub sijhawm nyob ntawm daim ntawv thov ntawm lub xaib ntawm daim ntawv thov.
MC Daim Ntawv Thov:
Cov Qauv Txuj Ci:
MC tau siv rau hauv cov tshuaj pleev cov yeeb yaj kiab, cov kua pleev, thiab tshuaj pleev xim rau qhov nws ua raws li lub thickening thiab ruaj khov rau kev sib tw thiab xwm yeem ntawm cov khoom.
Khoom noj khoom haus thiab nutraceuticals:
Hla kev siv tshuaj, MC nrhiav cov ntawv thov hauv cov khoom noj khoom haus thiab cov khoom noj khoom haus zoo li cov ntaub tuab, emulsifier, thiab stabiliting, txhawb nqa rau cov qauv thiab muaj zog ntawm ntau yam khoom.
Hauv cov ntsiab lus, HPMC thiab MC yog ob qho txiaj ntsig cellulose derivatives nrog cov yam ntxwv sib txawv uas ua rau lawv haum rau ntau daim ntaub ntawv thov tshuaj. HPMC, nrog nws tus ntiv tes tshaj plaws hauv dej kub thiab txias, thiab cov tshuaj pleev xim ua yeeb yam, yog qhov tshwj xeeb tshaj plaws rau kev tso tawm, thiab cov tshuaj lom neeg thiab ophthalmic npaj. MC, thaum yooj yim nyob rau hauv muaj pes tsawg leeg, muaj cov txiaj ntsig zoo hauv solubility thiab qis dua qhov kev tsis sib haum, thiab cov neeg sawv cev ua kom zoo rau hauv cov ntawv thov tshwj xeeb. Nkag siab txog qhov sib txawv ntawm lawv cov qauv siv tshuaj, thiab kev ua haujlwm pub rau cov kws sau ntawv tsim nyog kom tau raws li cov khoom lag luam uas tsim nyog ntawm cov tshuaj.
Lub Sijhawm Post: Feb-18-2025