Hydroxypropylencellulose (HPMC) yog qhov sib txuas ntxiv siv hauv kev lag luam ntau yam, suav nrog cov tshuaj, cov khoom noj thiab cov tshuaj pleev ib ce thiab tshuaj pleev ib ce. Nws yog qhov ua kom pom tseeb ntawm cellulose thiab feem ntau siv los ua cov tuab dua, stabilizer thiab emulsifier ntawm ntau yam khoom. Kev nyab xeeb ntawm HPMC rau tib neeg kev noj yog nyob ntawm ntau yam, suav nrog nws qhov chaw, thiab daim ntawv thov tshwj xeeb.
1. DiCemical qauv thiab qhov chaw:
HPMC yog muab tau los ntawm cellulose, ib qho tshwm sim polymer hauv cov phab ntsa cell. Cov txheej txheem tsim khoom lag luam cuam tshuam nrog kho cellulose los ntawm kev ntxiv cov tshuaj pleev cov olylene oxide thiab methylene chloride. Lub hauv paus ntawm cellulose thiab txoj kev tsim khoom lag luam tshwj xeeb tuaj yeem cuam tshuam kev nyab xeeb ntawm HPMC kawg cov khoom lag luam.
2. Kev Kho Mob:
Hauv kev lag luam kws tshuaj, HPMC feem ntau siv raws li qhov kev zam ntawm qhov ncauj thiab cov tshuaj pleev ib yam. Nws ua raws li cov phau ntawv sib tsoo, ua txhaum thiab tswj tso tawm tso tawm. Kws Tshuaj HPMC undergoes nruj zoo tswj kev ua kom paub tseeb thiab kev nyab xeeb. Teb chaws Amelikas (USP) thiab lwm cov chaw tswj hwm muab cov kev coj qhia rau kev siv HPMC hauv cov qauv tshuaj, kom ntseeg tau tias qee yam qauv tau ua tiav.
3. Kev lag luam khoom noj:
Hauv kev lag luam khoom noj, HPMC yog siv los ua cov tuab, stabilizer thiab emulsifier nyob rau ntau yam khoom lag luam suav nrog cov ntses, cov khoom qab zib thiab cov khoom ci. Cov Khoom Noj HPMC yuav tsum ua raws li cov kev cai tsim los ntawm cov chaw muaj kev nyab xeeb khoom noj, xws li Asmeskas Kev Nyab Xeeb Khoom Noj (FDA) thiab European). Cov koom haum no tshuaj xyuas kev nyab xeeb ntawm cov khoom noj khoom haus cov zaub mov, suav nrog HPMC, raws li kev kawm toxicity thiab kev ntsuas kev sib tw.
4. Cov tshuaj pleev ib ce thiab cov khoom siv saib xyuas tus kheej:
HPMC kuj tseem siv rau hauv cov tshuaj pleev ib ce thiab cov khoom siv saib xyuas tus kheej, suav nrog tshuaj pleev, pleev xim thiab tshuaj zawv plaub hau. Kev pleev xim kom zoo nkauj HPMC feem ntau suav tias yog kev nyab xeeb, tab sis nws muaj kev nyab xeeb yuav yog nyob ntawm qhov tsim txhua yam. Cov koom haum tswj hwm xws li FDA thiab European tshuaj chaw ua hauj lwm (EMA) muab kev qhia rau kev siv HPMC hauv Tshuaj pleev ib ce.
5. Kev Tshawb Fawb Kev Nyab Xeeb:
Ntau txoj kev tshawb fawb tau tshawb fawb txog kev nyab xeeb HPMC. Cov kev tshawb fawb no suav nrog kev ntsuas ntsuas ntawm cov kuab lom, subchronic toxicity, mutagenicity thiab kev ua me nyuam toxicity. Zuag qhia tag nrho, muaj cov pov thawj qhia tau hais tias HPMC feem ntau muaj kev nyab xeeb thaum siv ntawm cov tshuaj loog, thiab cov tshuaj pleev ib ce, thiab tshuaj pleev ib ce.
6. Cov peev xwm tshwm sim:
Thaum HPMC yog feem ntau suav tias muaj kev nyab xeeb, qee tus neeg yuav tshwm sim tau cov kev tshwm sim ntawm kev tsis txaus siab, xws li tsis ncaj ncees qhov tsis xis nyob, thaum noj ntau. Nws yog ib qho tseem ceeb kom ua raws li cov lus qhia siv tau siv los ntawm cov koom haum tswj hwm thiab cov khoom lag luam cov khoom lag luam.
7. Kev tswj hwm kev saib xyuas:
Kev nyab xeeb ntawm HPMC yog kev saib xyuas los ntawm kev tswj hwm hauv ntau lub tebchaws. Cov koom haum tswj hwm tau teeb tsa cov khoom siv txhua hnub (ADI) ntau qib rau cov khoom noj khoom haus ntxiv thiab tsim cov lus qhia rau lawv siv. Ua raws li cov kev cai no pab kom muaj kev nyab xeeb ntawm cov khoom muaj HPMC.
HydroxyPropy muag methylcellulose feem ntau suav hais tias muaj kev nyab xeeb rau tib neeg kev noj haus thaum siv raws li cov qauv kev tswj hwm thiab cov qauv kev lag luam. Kev nyab xeeb ntawm HPMC nyob ntawm yam xws li nws cov khoom siv, huv, thiab kev thov. Raws li nrog ib qho tshuaj, nws yog ib qho tseem ceeb rau cov khoom lag luam uas muaj HPMC raws li qhia thiab tham txog kev saib xyuas kev noj qab haus huv yog tias muaj kev txhawj xeeb txog kev noj qab haus huv.
Lub Sijhawm Post: Feb-19-2025