HydroxyPropyyl methylcellose (HPMC) yog cov dej-soluble polymer sib xyaw ua ke hauv cov tshuaj, khoom noj khoom haus, cov ntaub ntawv tsim tsev thiab lwm thaj teb. Qhov zoo ntawm nws cov khoom zoo cuam tshuam rau kev ua tau zoo thiab kev ruaj ntseg ntawm cov khoom.
1. Tsos thiab xim
Cov tsos thiab cov xim muaj cov hau kev ua ntej los ntsuas qhov zoo ntawm hydroxyprropy muag methylulose. Zoo Zoo HPMC feem ntau yog dawb lossis tawv nqaij dawb nrog cov khaub ncaws zoo nkauj thiab cov khoom siv zoo nkauj. Cov xim yuav tsum tsis txhob yog daj, xim av lossis ib qho tsis muaj xim, uas tuaj yeem yog vim tsis zoo los ntawm kev ua kom tsis muaj peev xwm los yog tsis muaj peev xwm thaum lub sijhawm tsim khoom. Yog tias cov xim yog qhov txawv txav, nws tuaj yeem qhia tau tias muaj teeb meem nrog cov khoom lag luam thiab kev tshuaj xyuas ntxiv.
2. Hmoov particle loj muab faib
Particle loj muab faib yog ib qho ntawm cov tseem ceeb hauv kev ntsuas qhov zoo HPMC. HPMC ntawm cov khoom zoo feem ntau muaj cov khaub ncaws tsis sib xws. Qhov loj dhau los yog cov me me me me yuav cuam tshuam nws solubility thiab cuam tshuam rau cov kev siv cov kev siv. Lub particle loj tuaj yeem txheeb xyuas los ntawm sieving los yog laser ittle loj analyzer. Cov lus loj dhau yuav ua rau cov tub rog tsis muaj zog thiab cuam tshuam nws cov viscosity thiab kev sib dhos. Cov txheej txheem sib tsoo sib txawv tuaj yeem siv rau hauv kev faib cov khoom faib kom ntseeg tau tias HPMC tuaj yeem ua tau zoo nyob rau hauv cov ntawv thov.
3. Dej solubility thiab cov lej kawg
Cov dej so ntawm HPMC yog qhov taw qhia tseem ceeb rau kev ntsuam xyuas nws cov khoom zoo. Nws cov kev ua yeeb yam yog cuam tshuam los ntawm cov qauv molecular thiab cov qib hloov chaw ntawm hydroxypropyl thiab methyl pawg. Zoo HPMC tuaj yeem yaj tau sai sai hauv dej los ua ib qho kev daws teeb meem thiab cov khoom siv sib dhos. Txhawm rau sim cov dej solubility, ib qho nyiaj ntawm HPMC tuaj yeem raug ntxiv rau dej, nplawm ntawm qhov kub thiab txias, thiab kev sib cais tom qab sib hais tau. Yog hais tias nws yaj maj mam los yog tsim cov lumruble tsis muaj leump, nws yuav yog tias HPMC zoo tsis tsim nyog.
4. Viscosity Test
Lub viscos huab ntawm HPMC yog qhov ntsuas tau tseem ceeb ntawm nws qhov zoo, tshwj xeeb tshaj yog thaum nws siv los ua cov tuab tuab, emulsifier lossis tus neeg saib xyuas. Viscosity feem ntau cuam tshuam nrog txoj kev molecular thiab qib degree hloov chaw ntawm HPMC. Nws cov viscosity tuaj yeem kuaj los ntawm cov visical viscometer los yog REEUALETER los ntsuas nws cov khoom sib dhos. Qhov tsim nyog, lub viscosity ntawm HPMC yuav tsum ruaj khov nyob rau hauv qee yam los xyuas kom nws ua tau zoo hauv ntau yam kev siv.
Thaum kuaj cov viscosity, HPMC yuav tsum tau yaj ntawm cov dej, qhov kub yuav tsum tau hloov kho, thiab kev kub siab ntawm cov tshuaj ntawm cov nqi sib txawv yuav tsum tau ntsuas. Yog tias qhov viscosity yog txawv txav, nws yuav cuam tshuam kev ua haujlwm ntawm HPMC, tshwj xeeb tshaj yog nyob rau hauv cov ntawv thov uas muaj cov viscosity siab.
5. Kev txiav txim siab ntawm qib ntawm kev hloov chaw
Cov qib degree hloov pauv (DS) yog hais txog kev faib ua feem ntawm hydroxypropyl thiab methyl pawg hauv HPMC molecule. Cov qib degree hloov pauv nws solubility, viscosity thiab tshuaj siv lub cev thiab tshuaj lom neeg. Cov tswv yim xws li infrared spectroscopy (ftir) lossis siv cov cim sib nqus ntawm methyl thiab hydroxyprodropyl hauv HPMC lwg me me.
Rau kev ua tau zoo HPMC, qib degree hloov chaw yuav tsum nyob hauv cov kev cai tshwj xeeb. Siab dhau los yog qis dhau ntawm qib degree hloov yuav ua rau muaj kev tsis ruaj khov thiab cuam tshuam qhov zoo ntawm cov khoom kawg. Piv txwv li, dhau ntawm methey hloov pauv nws cov dej ua kua, thaum lub sijhawm poob qis heev tuaj yeem cuam tshuam rau nws cov kev ua tuab tuab.
6. Kev txiav txim siab ntawm cov ntsiab lus noo noo
Cov ntsiab lus noo noo yog ib qho tseem ceeb rau qhov ua tau zoo HPMC. Siab heev cov ntsiab lus ya raws yuav ua rau cov khoom lag luam thiab agglomerate, yog li cuam tshuam nws cov kev ua tau zoo. Cov dej noo noo yog feem ntau txiav txim los ntawm ziab lossis Karl Fischer lub tsev pheeb suab. Cov dej noo cov ntsiab lus ntawm cov zoo HPMC yuav tsum tsawg dua 5% kom ntseeg tau tias nws qhov zoo tsis hloov thaum lub sijhawm cia thiab siv.
7. Phuam
Tus lej PHOT ntawm HPMC kev daws teeb meem tseem yog qhov taw qhia tseem ceeb ntawm nws qhov zoo. Kev daws ntawm HPMC yuav tsum muaj tus nqi pH ruaj khov, feem ntau ntawm 4.0 thiab 8.0. Tshaj tawm cov kua qaub lossis cov kev daws teeb meem alkaline yuav cuam tshuam nws cov kev ruaj ntseg thiab ua haujlwm hauv daim ntawv thov. Tus nqi PH yuav txiav txim siab los ntawm ntsuas ntsuas ncaj qha PH
8. Microbiological Testing
HPMC yog ib qho kev zam tshwj xeeb siv nyob rau hauv cov tshuaj thiab khoom noj khoom haus, thiab nws cov microbial kev xav tau kev saib xyuas tshwj xeeb. Cov me me paug tsis yog cuam tshuam rau kev nyab xeeb ntawm cov khoom lag luam, tab sis kuj yuav ua rau cov khoom lag luam rau tsis zoo lossis tsis zoo hauv kev ua tau zoo. Kev kuaj microbial tuaj yeem nqa tawm los ntawm kab lis kev cai, PC thiab lwm txoj hauv kev kom ntseeg tau tias Hurgiene cov qauv ntawm HPMC ua tau raws li cov cai ntawm kev xav tau.
9. Thermograveimetric Kev Ntsuam Xyuas (TGA) thiab kev ntsuas calorimetry (DSC)
Thermogravetric tsom (TGA) thiab kev ntsuas calorimetry (DSC) thiab siv tau los kawm txog HPMC thiab nws cov yam ntxwv decomposition thaum cua sov. Cov hau kev no tuaj yeem tau txais cov ntaub ntawv tseem ceeb xws li cov teeb meem loj, melting point, thiab iav hloov tsheb kub los pab txiav txim siab seb nws yuav tsum tau ua daim ntawv thov tshwj xeeb.
10. Kev txiav txim siab ntawm cov chloride cov ntsiab lus
Yog HPMC muaj ntau dhau chloride, nws yuav cuam tshuam nws solubility thiab ruaj khov hauv kev thov. Nws cov chloride cov ntsiab lus tuaj yeem txiav txim siab los ntawm nplaim duab raj photometry lossis potentiometric lub part. Cov chloride cov ntsiab lus ntawm HPMC nrog kev ua tau zoo yuav tsum tau tswj tsis pub dhau qee yam los xyuas kom nws muaj kev nyab xeeb thiab ua haujlwm zoo.
Cov hau kev saum toj no tuaj yeem nkag siab qhov zoo ntawm hydroxypropylulose, solubility, Qib ntawm kev hloov chaw, cov ntsiab lus noo noo thiab lwm yam. Cov kev siv sib txawv muaj cov sib txawv rau HPMC, yog li thaum ntsuas nws qhov zoo, nws yog qhov tsim nyog los ua kev sim ua ke nrog cov kev xav tau ntawm cov ntawv thov cov ntawv thov. Cov qauv kev sim no tuaj yeem ua kom muaj kev ruaj ntseg, ua haujlwm thiab kev nyab xeeb ntawm HPMC cov khoom lag luam, muab kev lav tau rau lawv cov ntawv thov dav.
Lub Sijhawm Post: Feb-14-2025