Cov ntsiab lus ntawm hydroxypropyl methylcellose HPMC cov khoom

HydroxyPropy cellulose HPMC yog hom tsis muaj ionic cellulose sib xyaw ether, thiab nws tsis hnov ​​zoo nrog cov hlau hnyav. Vim muaj cov ntsiab lus sib txawv ntawm methoxyl cov ntsiab lus hauv hydroxyls thiab ntau cov ntsiab lus me me, nws tau ua ntau yam methoxyl cov ntsiab lus thiab cov kev ua tau zoo hydroxylopyls thiab nws cov kev ua tau zoo nyob ze rau ntawd HydroxyPropyyl methylulose. Txawm li cas los xij, nyob rau ntau yam ntau yam, txawm hais tias muaj me me ntawm hydroxy pawg muaj, cov solubility pab pawg muaj, cov solubilation hauv organic kub nyob rau hauv cov kua aqueous muaj ntau heev.

1. Lub solubility ntawm hydroxypropyl methylcellose
①solubility ntawm hydroxypropyl cellulose hauv dej hydroxypropyl cellulose los ntawm methyl oxyprropene), yog li nws tseem muaj tib yam ntxwv me me li methyl cellulose. Cellulose yog zoo ib yam nyob rau hauv dej txias solubility thiab dej kub insolubility. Txawm li cas los xij, vim hloov kho hydroxypropylropyl pab pawg, nws gelation kub hauv dej kub yog ntau dua li ntawm methyl cellulose. Piv txwv, cov tshuaj viscosity ntawm cov kua ahoxy ntawm hydroxypropylulose nrog 2% mexhoxyl cov ntsiab lus ms = 0.46 yog 500 mpa? S ntawm 20 ° C. Nws cov kua kub kub nws tuaj yeem ncav cuag ze li 100 ° C, thaum methylcellulose nyob rau tib qhov kub tsuas yog kwv yees li 55 ° C. Raws li rau nws solubility hauv dej, nws kuj tau txhim kho zoo heev. Piv txwv li, tus pulverized hydroxypropyl methylcellulose (granular duab ntawm 0.2 ~ aqueous daws tau li ntawm 2pa? Soluble hauv dej yam tsis muaj txias.

②HTHTHTHT SOLUBILDE NTAWM Hydroxypropyl cellulose hauv cov txheej txheem ntawm methoxsciles hauv cov khoom siv methoxyline Methoxy Ds = 0.2 ~ 1.0, thiab tag nrho cov kev hloov pauv saum toj kawg nkaus li 1.8 yog solubloat daws nruab nrab, thermoplastic thiab dej-soluble. Nws tseem yog soluble hauv chlorinated hydrocarbons xws li dichhloromethane thiab hauv cov kuab tshuaj organic xws li acetone, isopropanol thiab diacetone cawv. Nws cov solubility hauv cov kuab tshuaj yeeb yaj kiab yog qhov zoo dua li cov dej-soluble.

2. Qhov xwm txheej cuam tshuam rau cov viscosity ntawm hydroxypropyl methylulose
Zom cov ntsiab lus ntawm hydroxypropyl methylroposyl cellws, zoo li lwm yam kev hais ua cellulose, zoo li cov tshuaj aquous li ntawm 20 ° C. Lub viscosity ntawm tib qho khoom nce nrog kev nce ntawm kev xav. Rau cov khoom lag luam hnyav molecular hnyav nyob rau tib lub siab, cov khoom uas muaj hnyav hnyav molecular muaj ntau hom viscosity. Nws txoj kev sib raug zoo nrog qhov kub zoo ib yam li methyl cellulose. Thaum qhov ntsuas kub nce ntxiv, lub viscosity pib txo qis, tab sis thaum nws mus txog ib qho kub thiab txias thiab pom kev. Lub gel kub ntawm cov khoom lag luam tsawg-viscosity yog siab dua. yog siab. Nws cov gel point tsis tsuas muaj feem cuam tshuam nrog cov viscosity ntawm kev sib xyaw ntawm methoxy thiab hydroxyprropyl hauv Etaws thiab tag nrho cov qib ntawm qhov hloov chaw. Nws yuav tsum raug sau tseg tias hydroxypropylulose kuj tseem muaj pseudopcastic thiab nws cov kev daws teeb meem yog ruaj khov ntawm chav viscosity tsuas yog ua tau ntawm enzymatic degradation.

3. HydroxyPropyyl methylculose acid thiab alkali tsis kam
HydroxyPropyl methylulose acid thiab alkali ua rau hydroxypropylulose feem ntau ruaj khov rau cov kua qaub thiab alkali, thiab tsis cuam tshuam nyob rau hauv ntau ntawm PH 2 ~ 12. Nws tuaj yeem tiv taus qee qhov nyiaj ntawm lub teeb qaub. Xws li formic acid, acricic acid, supricic acid, succinic acid, boric acid, etc. Txawm li cas los xij, muaj txiaj ntsig ntawm kev txo viscosity. Alkali xws li caustic dej qab zib, feustic dej thiab txiv qaub tsis muaj kev cuam tshuam ntawm kev daws teeb meem, thiab tom qab ntawd yuav muaj qhov tshwm sim ntawm kev poob qeeb qeeb yav tom ntej.

4. Kev sib xyaw ntawm hydroxypropyl methylcellose
Kev ua kom tsis meej ntawm hydroxypropy cellulropyl cellulose hydulpropyl cellws cell tuaj yeem ua ib qho kev sib xyaw thiab cov khoom siv hluav taws xob nrog cov viscosity ntau dua. Cov kab ke polymer suav nrog polyethylene glycol, polyvinyl acetate, polysiloxane, hydroxyethyl cellulose thiab methyl cellulose. Tej thaj av polymer xws li cov pos hniav Arabic, Karaya Gum, thiab lwm yam kuj muaj kev sib xyaw zoo nrog nws cov tshuaj. HydroxyPropyyl methylcellulose kuj tseem tuaj yeem sib xyaw nrog mannitol lossis sorbitol esters ntawm stearic acid lossis kuj tseem tuaj yeem sib xyaw nrog glycitur, sorbitol thiab mannitol. Cov tebchaw no tuaj yeem siv los ua hydroxypropyl methylulose. Cellulose-based yas.

5. Insolubility thiab dej solubility ntawm hydroxypropyf methylcellose
Lub insolubilized dej-soluble cellulose kev ua neeg tau muaj kev hais txog medroxyprropylulose nrog aldehydes tau yog precipitated hauv kev daws thiab ua insoluble hauv dej. Lub aldehydes uas ua hydroxypropyluluchlulose insoluble suav nrog formaldehyde, gucaldehyde, occaldehyde, green Yog li ntawd, glyoxal feem ntau siv los ua tus neeg sawv cev hla kev lag luam. Qhov ntau npaum li cas ntawm hom kev sib txuas ntawm cov kev daws teeb meem yog 0.2% ~ 10%, thiab 3.3% ~ 6% yog qhov haum rau glyoxal. Qhov kev kho dav dav yog 0 ~ 30 ℃, thiab lub sijhawm yog 1 ~ 120min. Cov tshuaj tiv thaiv kev sib txuas hla kev xav tau yuav tsum tau ua raws li cov acidic. Feem ntau, inorganic cov kua qaub muaj zog lossis cov organic carboxylic acid tau ntxiv txog 2 ~ 6, thiab tom qab ntawd aldehydes ntxiv los ua cov tshuaj tiv thaiv kab ntsig. Cov. Cov kua qaub siv suav nrog hydrochloric acid, phosfuric acid, formic acid, accetic acid, formic acid, thiab cov accetic acid yog qhov kev pom zoo tshaj plaws. Cov kua qaub thiab aldehyde tseem tuaj yeem ntxiv ib txhij los cia cov kev daws teeb meem los hla cov phob xav tau. Qhov kev cuam tshuam no feem ntau siv nyob rau hauv cov txheej txheem kev kho xwm txheej kawg hauv kev npaj npaj ntawm cellulose muaj kev hais ua neeg muaj kev hais ua. Tom qab lub cellulose ether yog insolubilized, nws yog qhov yooj yim ntxuav thiab ua kom huv nrog dej ntawm 20 ~ 25 ° C. Thaum cov khoom siv tau siv, ib qho khoom lag luam alkaline tuaj yeem raug ntxiv rau kev daws teeb meem los kho cov phy kev daws teeb meem yog alkaline, thiab cov khoom yuav yaj tawm hauv cov kev daws teeb meem sai. Hom qauv no tseem siv tau rau lub cellulose cov tshuaj ua rau hauv zaj duab xis thiab ces zaj duab xis yog ua kom nws ua kom muaj cov yeeb yaj kiab insoluble.

6. HydroxyPropyyl methylcellulose yog tiv taus enzymes
HydroxyPropyyl methylcellulose yog resistant rau enzymes. Hauv kev tshawb xav, xws li ib pab pawg muaj txiaj ntsig, tab sis qhov tseeb tau ua tiav cov khoom siv ntawm cov kab mob cellul unsubstub anhydoglucose pawg los ua cov suab thaj. , uas yog nqus tau li cov as-ham rau cov microorganisms. Yog li ntawd, yog tias lub Ericelation hloov kho qib ntawm cellulose nce, qhov tsis kam mus rau enzymatic yaig ether kuj yog txhim kho. Nws tau tshaj tawm tias cov residual viscosity ntawm hydroxypropylulose (DS = 1.83) yog 3.83) yog 3.83) yog 3.8%, thiab hydroxyethyl cellulose yog 1.7%. Nws tuaj yeem pom tau tias kev tawm tsam enzyme enzyme muaj peev xwm ntawm mydroxypropyl methylulose yog muaj zog. Yog li ntawd, cov enzyme tsis kam ntawm hydroxypropylulose, ua ke nrog nws cov khoom siv ua kom zoo, thiab feem ntau tsis tas yuav ntxiv ntawm cov tshuaj tiv thaiv. Txawm li cas los xij, rau lub sijhawm ntev cia ntawm cov kev daws teeb meem lossis cov kev tsis sib haum xeeb tuaj yeem ntxiv ua kev tiv thaiv sab nraud, thiab cov kev xaiv tuaj yeem raug txiav txim siab raws li cov kev daws teeb meem kawg. Penyylmeric acetate thiab manganese fluorosilicate muaj txiaj ntsig zoo, tab sis lawv muaj kev lom zem, thiab cov tshuaj lom neeg feem ntau 1 ~ 5mg ntawm phenylmuric ib litre.

7. Cov khoom ntawm hydroxypropyl methylcellulose zaj duab xis
Kev ua yeeb yam ntawm hydroxypropyl methylcellose zaj duab xis HydroxyPropylen Cov khoom, thiab nws cov organic kev daws teeb meem yog pleev xim rau ntawm lub khob iav, thiab nws ua pob tshab thiab pob tshab tom qab ziab. Thiab tawv zaj duab xis. Nws muaj zoo noo noo tsis kam thiab tseem ruaj khov ntawm qhov kub. Piv txwv li, ntxiv hygroscopic yas tuaj yeem txhim kho nws txoj kev elongation thiab yooj. Txhawm rau txhim kho kev hloov tau yooj yim, cov yas xws li glycerol yog qhov haum tshaj plaws. Cov kev daws teeb meem dav dav yog 2% ~ 3%, thiab tus nqi ntawm cov yas muaj 10% ~ 20% ntawm cellulose ether. Yog tias cov ntsiab lus ntawm cov yas cua muaj siab dhau, qhov tsis txaus siab ntawm lub cev qhuav dej ntawm lub cev qhuav dej yuav tshwm sim hauv cov av noo. Lub zog tensile ntawm zaj yeeb yaj kiab nrog cov yas ua kom loj dua li tias tsis muaj lub tshuab yas, thiab nws nce nrog kev nce ntxiv tus nqi ntxiv. Raws li rau cov hygroscopicity ntawm zaj duab xis, nws kuj nce nrog qhov nce ntawm tus nqi yas.