HydroxyPropyyl Metylcellulose (HPMC) yog cov hluavtaws polymer compound dav siv hauv cov tshuaj, kev tsim kho, tshuaj pleev thiab lwm thaj teb. Nws muaj cov dej zoo heev solubility, colloidal muaj zog thiab ruaj khov, yog li nws muaj cov ntawv thov tseem ceeb hauv ntau qhov kev lag luam. Txhawm rau kom ntseeg tau tias nws cov khoom zoo thiab huv, cov cim qhia kom tsim nyog yog tsim nyog. Hauv qab no yog ob peb txoj kev qhia ua kom yooj yim rau hydroxypropylulose (HPMC), solubility, solubility, infrared spectrum thiab tshuaj lom neeg.
1. Cov tsos pom
HPMC feem ntau yog ib qho dawb rau cov hmoov dawb lossis cov hmoov av granular, tsw ntxhiab thiab tsis muaj qab. Los ntawm kev saib nws lub ntsej muag, koj tuaj yeem ua tus kws txiav txim siab ua ntej seb nws puas yog HPMC ntshiab. Cov xim hloov pauv lossis lub xub ntiag ntawm cov impurities yuav qhia tau tias cov qauv yog qhov tsis huv lossis paug.
2. Solubility Tus Kheej
HPMC muaj solubility zoo, tshwj xeeb tshaj yog nyob rau hauv dej. Muab ib qho me me ntawm cov qauv hauv dej thiab ua pa maj mam muab. Yog tias nws tuaj yeem yaj sai thiab tsim cov kev daws teeb meem colloloidal, nws txhais tau tias cov qauv yog hydroxypropyl methylulose. Qhov ceev ntawm kev sib cais thiab lub viscosity ntawm kev daws teeb meem yuav cuam tshuam nrog molecular qhov hnyav ntawm HPMC thiab cov ntsiab lus ntawm HydroxyPropyl thiab methyl pawg.
Nyob rau tib lub sijhawm, cov solubility ntawm HPMC hauv cov kuab tshuaj organic kuj tseem siv tau ua tus qauv cim. HPMC yog soluble nyob rau hauv feem ntau cov emvents organic (xws li acetone, ethanol, thiab lwm yam), tab sis insoluble hauv cov kuab tshuaj rog rog. Cov xeeb ceem no tuaj yeem lees paub ntxiv los ntawm kev sim nws cov solubility hauv cov kuab tshuaj uas tsim nyog.
3. Infrared spectroscopy (ir) qhia
Infrared spectroscopy (ir) yog ib qho kev txheeb xyuas qhov tseeb uas tuaj yeem pab lees paub cov qauv molecular ntawm HPMC. Cov txheej txheem tseem ceeb ntawm HPMC yog cov pab pawg uas suav nrog cov pab pawg xws li methyl (-ch3) thiab hydroxypropyl (Oh) CH3). Lub xub ntiag ntawm cov pab pawg no tuaj yeem lees paub los ntawm kev nqus cov peaks ntawm tus ir spectrum.
Cov yam ntxwv nqus tau peaks ntawm HPMC tus ir spectrum suav nrog:
2920 CM-1 (ch Ncab kev co)
1450 cm-1 (ch pua tsev kev co)
1100-1200 CM-1 (Coc Ncab ncab Kev Cibration)
3400 cm-1 (Oh Ncab xyab kev co, tus nqi ncov yuav hloov vim muaj dej)
Los ntawm kev sib piv ntawm cov qauv HPMC tus qauv, nws tuaj yeem piv nrog cov spectrum ntawm cov qauv tsis paub meej kom paub meej tias yog tus qauv.
4. Kev siv tshuaj ntsuam xyuas cov cim
HPMC, raws li ether compound, muaj qee cov tshuaj tiv thaiv tshuaj lom neeg thiab tuaj yeem txheeb xyuas los ntawm cov tshuaj tiv thaiv hauv qab no.
(1) cov tshuaj tiv thaiv nyob rau hauv acidic tej yam kev mob:
Daws ib qho nyiaj me me ntawm HPMC hauv dej, ntxiv dilute hydrochloric acid, thiab cua sov. Yog hais tias ib qho tshuaj sib tov tshwm sim hauv kev daws teeb meem, nws txhais tau tias nws muaj HPMC. Qhov kev tawm tsam no tuaj yeem txheeb tau los ntawm cov qauv kev ruaj ntseg ntawm hydroxypropyl thiab methyl pawg nyob hauv acidic tej yam kev mob.
(2) cov tshuaj tiv thaiv nyob rau hauv Alkaline tej yam kev mob: HPMC tau ploj mus rau hauv dej los ua ib qho kev daws colloidal. Nws tsis yooj yim kom yaj nyob rau hauv cov kev mob hydroxide tov), uas muaj feem rau nws Hydrophilicity thiab Hydrogel Khoom. Yog tias qhov kev daws teeb meem yog turbid lossis precipitated, nws txhais tau tias HPMC yog tam sim no.
5. Kev qhia txog tus qauv HPMC yog ib qho tshuaj nrog cov yam ntxwv viscosity, yog li nws tuaj yeem txheeb tau los ntawm nws cov viscosity nyob rau hauv aqueous daws. Feem ntau hais lus, HPMC yuav tsim cov tshuaj colloidal nrog qee yam viscosity tom qab ua rau muaj qhov dej viscosity tom qab qhov nce ntawm nws cov molecular hnyav.
Txhawm rau ntsuas qhov viscosity, lub fluidity ntawm HPMC kev daws teeb meem yuav ntsuas los ntawm kev siv cov vis viscometer lossis iav raj vis tod. Raws li cov molecular hnyav ntawm HPMC thiab cov concentration ntawm kev daws teeb meem, nws hom viscosity tuaj yeem kwv yees. Yog tias cov qauv viscosity yog qhov qis dua li ntawm kev daws teeb meem HPMC, nws yuav qhia tau tias nws cov khoom xyaw tsis zoo lossis lub cev hnyav yog tsawg.
6. Melting taw tes / decomposition tes kuaj HPMC, feem ntau tsis muaj lub ntsej muag melting, tab sis yuav qhia cov muag muag lossis kev ua si ntawm cua sov. Thaum HPMC yog rhuab, nws cov kev hloov pauv ntawm ntau qhov kub thiab txias tuaj yeem pom. Feem ntau hais lus, HPMC yuav pib txi ntawm 180-200 ℃, tso qee yam tshuaj tsw qab (xws li dej thiab cov organic kuab). Qhov hloov pauv ntawm cov decompositionate tuaj yeem paub meej ntxiv tias cov qauv no yog HPMC ntshiab.
7. Solubility thiab nto nro txujci
Cov kev daws teeb meem tom qab hpmc dissolves feem ntau muaj qhov nro qis. Qhov nro muaj kev ntxhov siab ntawm HPMC kev daws teeb meem yuav ntsuas tau siv tus txheej txheem sab tensiometer lossis ib txoj kev nrog dej. Yog tias nws phim rau qhov nro ntawm cov qauv daws, nws txhais tau tias cov qauv yog HPMC.
Qhov saum toj no qhia ntau hom kev sib txawv thiab cov txheej txheem yooj yim rau kev txheeb xyuas Hydroxypropyl methylulose (HPMC). Cov hau kev no qhia txog HPMC los ntawm ntau cov ces kaum, solubility, tshuaj lom neeg muaj peev xwm lees paub, muab nws daim ntawv thov hauv ntau qhov kev lag luam.
Lub Sijhawm Post: Feb-19-2025