HydroxyPropyyl methylcellose (HPMC) yog ntau cov kev lag luam polymer polmer siv nyob rau hauv ntau yam lag luam, khoom noj, tsim thiab tshuaj pleev ib ce. Txawm li cas los xij, zoo li lwm qhov sib txuas, HPMC muaj qee yam kev cov nyom thiab cov kev txwv.
1. Solubility Teeb Meem: HPMC feem ntau yog soluble hauv dej thiab organic kuab tshuaj xws li Methanol thiab ethanol. Txawm li cas los xij, nws cov solubility sib txawv nyob ntawm qhov xwm txheej xws li kev hnyav molecular, degree hloov chaw, thiab kub. Qib viscososity High Mill tuaj yeem nthuav cov nqi qeeb qeeb, uas tej zaum yuav muaj teeb meem kev txhaj tshuaj sai.
2. Viscosity Hloov: Lub viscosity ntawm HPMC kev daws teeb meem yog nyob ntawm ntau yam, suav nrog kev xav, kub, Ph thiab Shear tus nqi. Kev sib txawv hauv viscosity tuaj yeem ua rau muaj teeb meem hauv cov khoom lag luam zoo nkauj, tshwj xeeb yog cov chaw tshuaj thiab cov tshuaj pleev ib ce uas tswj tau qhov tseem ceeb.
3. Hygroscopicity: HPMC tau nqus dej noo los ntawm ib puag ncig ib puag ncig, ua rau hloov pauv ntawm nws cov khoom xws li xws li viscosity thiab ntws tus cwj pwm. Qhov kev sib tw no tuaj yeem tsim cov kev sib tw thaum lub sijhawm cia, tuav thiab ua, tshwj xeeb yog nyob rau hauv cov huab cua noo.
4. Thermal degradation: Thaum muaj kev mob siab rau cov cua sov, ua rau muaj kev hloov pauv ntawm cov roj molecular, viscosity thiab lwm yam khoom. Qhov no tuaj yeem tshwm sim thaum lub sij hawm ua xws li ziab lossis kub yaj extrusion, ua cov khoom muaj teeb meem zoo thiab ua haujlwm tsis zoo.
5. Cov teeb meem sib raug zoo: txawm hais tias HPMC feem ntau tau tshaj lwm yam kev zam thiab cov teeb meem ntxiv, muaj cov teeb meem sib txuas tau tshwm sim hauv qee yam qauv. Kev sib cuam tshuam nrog lwm cov khoom xyaw tuaj yeem cuam tshuam rau kev ruaj khov, solubility lossis bioavailability ntawm cov khoom kawg, yog li tsim cov khoom xyaw yuav tsum tau xaiv thiab ua kom zoo.
6. Phuam qhov tseeb: lub solubility thiab viscosity ntawm HPMC cuam tshuam los ntawm PHICE ntawm kev daws. Nyob rau hauv Alkaline tej yam kev mob, HPMC cov kev daws teeb meem yuav gel lossis nag lossis daus, txwv lawv cov kev haum xeeb hauv cov qauv. Ntawm qhov tod tes, kua qaub pH tuaj yeem txwv HPMC sijhawm dhau sijhawm, cuam tshuam cov khoom lag luam thiab kev ruaj khov.
7. Zaj duab zaj kev sib tw: HPMC feem ntau siv rau cov tshuaj ua cov tshuaj thiab cov ntsiav tshuaj vim nws cov yeeb yaj kiab zaj duab xis. Txawm li cas los xij, tau txais cov khaub ncaws hnav zoo nkauj thiab tsis muaj qhov tsis txaus ntseeg tuaj yeem nyuaj, tshwj xeeb tshaj yog rau cov viscc. Yam khoom xws li ziab qhov xwm txheej, cov khoom siv ua kom zoo thiab txheej txheej txheej txheem tsim nyog yuav tsum ua kom zoo ua kom zoo nkauj kom ntseeg tau qhov zoo.
8. Kev txiav txim siab tswj hwm: Cov kev cai tswj hwm thiab cov kev cai tshwj xeeb rau HPMC tuaj yeem sib txawv nyob ntawm cov ntawv thov thiab thaj chaw. Kev ua raws li cov kev cai thiab cov qauv kev cai lij choj, xws li cov kws kho mob lossis cov txheej txheem ua noj ua haus, tshwj xeeb rau cov khoom siv kom nruj kev lag luam.
9. Cov kev txiav txim siab tus nqi: HPMC feem ntau kim dua lwm cov kev ua haujlwm cellulose thiab polymers siv nyob rau hauv cov ntawv thov sib xws. Cov kev txiav txim siab tau txais kev txiav txim siab siv lossis xav tau kev txhim kho cov qauv tsim txiaj los ntawm kev ua kom zoo dua, kev ua cov tsis sib piv, lossis lwm yam kev zam tshwj xeeb.
10. Kev siv ib puag ncig: kev tsim khoom thiab pov tseg ntawm HPMC tuaj yeem muaj kev cuam tshuam ib puag ncig, suav nrog kev noj haus ib puag ncig kev siv zog, khib nyiab thiab muaj kuab paug. Raws li muaj kev ruaj ntseg los ua kev txhawj xeeb ntau dua rau kev lag luam thoob ntiaj teb, muaj kev hloov pauv ib puag ncig ib puag ncig rau HPMC lossis siv ntau yam kev ua haujlwm ntau lawm.
Thaum hydroxypropyl methylcellulose muaj ntau cov txiaj ntsig thiab kev siv thoob plaws kev sib tw, nws yog ib qho tseem ceeb kom paub txog kev sib tw thiab kev txwv cuam tshuam nrog nws siv. Hais txog cov teeb meem no los ntawm kev ceev faj tsim qauv kev tsim qauv, cov txheej txheem ua kom ua tau zoo, thiab ua raws li cov lus qhia ntawm HPMC thaum tseem ceeb tshaj plaws nws cov teeb meem.
Lub Sijhawm Post: Feb-18-2025