HydroxyPropyyl Methylcellulose(HPMC) yog cov khoom siv polymer uas muaj cov qoob loo ntau, txuas ntxiv dua, thiab cov dej solubility thiab ua yeeb yaj kiab zoo nkauj. Nws yog ib qho khoom siv raw rau kev npaj ntawm cov dej-soluble ntim cov yeeb yaj kiab.
Dej-soluble ntim zaj duab xis yog hom khoom lag luam ntim ntim ntsuab, uas tau txais cov khoom siv dav dav hauv Tebchaws Europe thiab lwm lub tebchaws. Nws tsis yog tsuas yog muaj kev nyab xeeb thiab yooj yim siv, tab sis kuj tseem ua cov teeb meem ntawm ntim khib nyiab pov tseg. Ntawm tam sim no, dej-solubble cov yeeb yaj kiab tsuas yog siv cov khoom siv roj av xws li polyvinyl cawv thiab polyethylene oxide raws li cov ntaub ntawv raw. Roj av yog cov khoom siv tsis-ntxiv, thiab kev siv ntau dua yuav ua rau cov khoom siv tsis txaus. Tseem muaj cov yeeb yaj kiab dej-soluble siv cov tshuaj ntsuab xws li cov hmoov txhuv nplej siab thiab protein ua cov duab raw, tab sis cov dej-soluble zaj duab xis muaj cov yeeb yam tsis zoo. Hauv daim ntawv no, ib hom tshiab ntawm cov dej-soluble ntim zaj duab xis tau npaj los ntawm kev daws teeb meem casting ua yeeb yaj kiab siv hydroxypropylulose li cov khoom siv raw. Qhov cuam tshuam ntawm cov concmc ua yeeb yaj kiab thiab ua yeeb yaj kiab ua si ntawm lub zog tensile, kev hloov chaw ntawm HPMC Dej-Soluble ntim cov yeeb yaj kiab tau sib tham txog. Glycerol, sorbitol thiab glutaraldehyde tau siv ntxiv txhim kho kev ua tau zoo ntawm HPMC dej-soluble ntim cov zaj duab xis. Thaum kawg, txhawm rau nthuav tawm cov ntawv thov ntawm HPMC dej-soluble ntim zaj duab xis hauv cov tshuaj antioxidant (AROG) tau siv los txhim kho cov tshuaj tiv thaiv kab mob hpmc dej-solmle. Lub ntsiab lus pom yog raws li hauv qab no:
(1) Nrog rau kev nce HPMC, lub zog tensile thiab elongation ntawm kev ua yeeb yaj kiab HPMC tau nce, thaum lub teeb kev hloov pauv loj. Thaum HPMC kev pom zoo yog 5% thiab zaj duab xis tsim kev kub yog 50 ° C, cov yeeb yaj kiab HPMC yog qhov zoo dua. Lub sijhawm no, lub zog tensile yog li 116MPA, lub elongation thaum tawg yog li 31%, qhov kev hloov pauv ntawm lub teeb yog 55min.
(2) Cov yas tshuab glycerol thiab sorbitol tau txhim kho cov khoom siv tshuab ntawm HPMC, uas nce siab dua lawv txoj kev txom nyem. Thaum cov ntsiab lus ntawm glycerol yog nyob nruab nrab ntawm 0.305% thiab 0.25%, cov nyhuv yog qhov zoo tshaj plaws, thiab elongation-soluble ntim cov zaj duab xis ncav cuag 50%; Thaum cov ntsiab lus ntawm Sorbitol yog 0.15%, lub elongation thaum tawg nce mus rau 45% lossis li ntawd. Tom qab HPMC dej-soluble ntim zaj duab xis tau hloov kho nrog glycerol thiab sorbitol, lub zog tensile thiab qhov kev txo qis tsis yog qhov tseem ceeb.
(3) infrared spectroscopy (FTIR) ntawm lub glutaraldehyde-crosslarhale-soluble ntim nrog cov yeeb yaj kiab, txo dej ntawm HPMC dej-soluble ntim cov zaj duab xis. Thaum qhov sib ntxiv ntawm glutaraldehyde yog 0.25%, cov khoom siv mechanical thiab kho qhov muag ntawm cov yeeb yaj kiab tau mus txog qhov zoo. Thaum qhov sib ntxiv ntawm glutaraldehyde yog 0.44%, dej-dispolving sijhawm txog 135 min.
(4) Ntxiv tus nqi tsim nyog ntawm Aob mus rau HPMC Dej-Soluble ntim zaj duab xis tuaj yeem txhim kho cov tshuaj antioxidant ntawm cov yeeb yaj kiab. Thaum 0.03% AOB tau ntxiv, Aob / HPMC zaj duab xis muaj qhov zoo tshaj plaws ntawm HPMC zoo tshaj li ntawm HPMC ua yeeb yaj kiab tsis muaj AOB, thiab cov dej solubility kuj tseem txhim kho.
Ntsiab lus: Soluble ntim zaj duab xis; HydroxyPropyyl methylulose; Cryizer; cross-txuas tus neeg sawv cev; antioxidant.
Cov txheej txheem
Ntsiab lus ..................................................... ....................................................................................... .i
Abstract Lwm Tiam ...................................................................................
Cov txheej txheem ................................................... ...................................................... .......................... i
Tshooj Lus Ib Leeg ................................................ .................................................... ........... ..1
1.1Txhua zaj yeeb yaj kiab ........................................................................... .1
1.1.1polyvinyl cawv (pva) dej-solubble zaj duab xis ................................................. 1
1.1.2polyethylene oxide (Peo) Dej-Soluble Zaj Duab Xis ................................................ ..2
1.1.3starch-based dej-solubble zaj duab xis ........................................................... .2
1.1.4 Protein-based dej-solubble cov yeeb yaj kiab ....................................................... .2
1.2 hydroxypropyl methylcellose ...................................................................
1.2.1 tus qauv ntawm hydroxypropylencellulose ................................................... .3
1.2.2 Dej Solubility ntawm HydroxyPropyyl Metylcellulose ............................................ 4
1.2.3 Zaj duab xis tsim ntawm hydroxypropylulose ....................................... .4
1.3 Kev hloov kho tau yooj yim ntawm HydroxyPropylencellulose zaj duab xis .................................................... ..4
1.4 Hla kev hloov kho ntawm hydroxypropyl methylcellulose zaj duab xis .................................... .5
1.5 antioxidative tej yam ntawm hydroxypropylencellulose zaj duab xis ........................................ 5
1.6 Cov lus thov ntawm cov ncauj lus .................................................................... .................................................. .7
1.7 Tshawb Fawb Cov Ntsiab Lus .......................................................................................................................................................... ..7
Tshooj 2 Kev Npaj thiab Khoom ntawm Hydroxypropy Cellulose Dej Tsev ........................................................................... .8
2.1 Lus Taw Qhia ............................................................................................... 8
2.2 Kev sim Tshooj ............................................................................ .................................................. .8
2.2.1 Kev sim cov khoom siv thiab cov khoom siv ............................................................................ ......... ..8
2.2.2 SPARIMEN UA ....................................................................... ..9
2.2.3 Ceeb tsheej thiab kev sim ntsuas ....................................................... .9
2.2.4 Cov ntaub ntawv ua ................................................... ...................................................... .................. 10
2.3 Cov Ntsiab Lus thiab Kev Sib Tham .................................................................. ......... 10
2.3.1 Cov nyhuv ntawm zaj duab xis ntawm kev daws teeb meem kev daws teeb meem ntawm HPMC nyias cov yeeb yaj kiab ........................................................................................ 10
2.3.2 Cawv Ntawm Zaj Duab Xis Tsim Kub Rau Hpmc Thin Films ................................................................................................................ ..13
2.2 Tshooj Lus Qhia Cov Ntsiab Lus ........................................................................................ 16
Tshooj 3 Cov Khoom Siv Ntawm Cov Yas Khib Rau Hpmc Dej-Soluble Ntim Cov Lus Qhia .................................................... ..17
3.1 Taw qhia ................................................................................................................................................ 17
3.2 TSHUAJ SEEM ....................................................................................17
3.2.1 Kev sim cov khoom siv thiab cov khoom siv ...........................................................................................
3.2.2 SPARIMEN npaj tau ....................................................................... 18
3.2.3 Ceeb tsheej thiab kev sim ua haujlwm ........................................................................18
3.2.4 Cov ntaub ntawv ua ........................................................................ ............................................... ..19
3.3 Cov Ntsiab Lus thiab Kev Sib Tham .......................................................................... 19
3.3.1 Cov nyhuv ntawm glycerol thiab sorbitol ntawm infrared nqus spectrum ntawm HPMC nyias cov yeeb yaj kiab ....................................................... .19
3.3.2 Cov nyhuv ntawm glycerol thiab sorbitol ntawm XRD qauv ntawm HPMC nyias cov yeeb yaj kiab ....................................................................................................
3.3.3 Cov teebmeem ntawm glycerol thiab sorbitol ntawm cov khoom siv tshuab hpmc nyias muaj ................................................................................................................................................... .21
3.3.4 Qhov cuam tshuam ntawm Glycerol thiab Sorbitol ntawm lub zog kho qhov muag ntawm HPMC Cov Yeeb Yaj Kiab ...................................................................................................................................................................
3.3.5 Cov cawv ntawm glycerol thiab sorbitol ntawm cov dej solubility ntawm HPMC cov yeeb yaj kiab .......... 23
3.............................................. .................................................................................... ..24
Tshooj 4 Qhov tshwm sim ntawm cov neeg sawv cev ntawm HPMC dej-solubble ntim cov yeeb yaj kiab ................................................................................ 25
4.1 Qhia ................................................................................... 25
4.2 Kev sim ntu ................................................................................ 25
4.2.1 Kev Tshawb Fawb Cov Khoom thiab Cov Khoom Siv ...................................... ........... 25
4.2.2 SPARIME UA HAUJ LWM ............................................................................... ..26
4.2.3 Ceeb toom thiab kev sim ua haujlwm ....................................................26
4.2.4 Cov ntaub ntawv ua ............................................................................ ............................................... ..26
4.3 Cov Ntsiab Lus thiab Kev Sib Tham .......................................................................
4.3.1 infrared nqus cov spectrum ntawm glutaraldehyde-crosslinked hpmc nyias cov yeeb yaj kiab ........................................................... ..27
4.3.2 XRD qauv ntawm Glutaraldehyde Hla HPMC Thin Cov Lus Qhia ................................................................................................................................ ..27
4.3.3 cov nyhuv ntawm glutaraldehyde ntawm dej solubility ntawm HPMC Cov Yeeb Yaj Kiab ....................... ..28
4.3.4 Cov nyhuv ntawm glutaraldehyde ntawm cov cuab yeej siv tshuab HPMC nyias cov yeeb yaj kiab ... 29
4.3.5 Cov nyhuv ntawm glutaraldehyde ntawm lub zog kho qhov muag ntawm HPMC cov yeeb yaj kiab ...........................
4.4 Tshooj Lus Nyeem ...
TSHEM TSEG 5 Natural Antioxidant Hpmc Dej-Soluble Ntim Zaj .................................. ..31
5.1 Qhia ...........................................................................................
5.2 Kev sim Tshooj ...................................................................................................
5.2.1 Kev sim cov khoom siv thiab cov cuab yeej sim .......................................................................................................... 31
5.2.2 Cov phiaj xwm npaj cia ..............................................................................32
5.2.3 Ceeb toom thiab kev sim ua ntsuas ...............................................................
5.2.4 Cov ntaub ntawv ua .................................................................... .............................................................. 33
5.3 Cov Ntsiab Lus thiab Kev Ntsuam Xyuas ....................................................................... .33
5.3.1 ft-m i mol-mulion .................................................................... 33
5.3.2 XRD analysis ………………………………………… ……………………………………………… ………..34
5.3.3 antioxidant thaj chaw ........................................................................................ 34
5.3.4 cov dej solubility ........................................................................... .35
5.3.5 Cov Khoom Siv Neeg Kho Tshuab .................................................................................... ..36
5.3.6 Kev Ua Tawm Zoo ............................................................................................ 37
5.4 Lus Qhia Tshooj Siab .......................................... .................................. ..........37
TSHOOJ 17 Xaus Download ........................................................................ .............................................. ..39
References ......................................................................................
Kev Tshawb Fawb Tawm Thaum Lub Sij Hawm Daus Quaj .............................................................................. Thia ..44
Kev lees paub .......................................................................................... .46
Tshooj Lus Ib Cov Lus Taw
Raws li phau ntawv tshiab ntim khoom, dej-soluble ntim zaj duab xis tau siv nyob rau hauv cov khoom txawv teb chaws (xws li Tebchaws Asmeskas, Nyiv, Fabkis, thiab lwm yam) [1]. Dej-soluble zaj duab xis, raws li lub npe implies, yog ib zaj duab xis yas uas tuaj yeem yaj hauv dej. Nws yog ua los ntawm cov dej-soluble cov ntaub ntawv uas tuaj yeem yaj hauv dej thiab tau npaj los ntawm cov txheej txheem zaj duab xis tshwj xeeb. Vim nws cov khoom tshwj xeeb, nws yog qhov haum rau cov neeg tau ntim. Yog li no ntau thiab ntau cov kws tshawb nrhiav tau pib ua tib zoo mloog rau qhov yuav tsum muaj kev tiv thaiv ib puag ncig thiab kev yooj yim [2].
1.1 Dej-Soluble zaj duab xis
Ntawm tam sim no, dej-solubble cov yeeb yaj kiab yog feem ntau cov zaj duab xis uas siv roj av xws li cov yeeb yaj kiab roj av xws li cov hmoov txhuv nplej siab xws li cov hmoov txhuv nplej siab xws li cov hmoov txhuv nplej siab thiab protein li cov ntaub ntawv raw.
1.1.1 polyvinyl cawv (PVA) Dej-Soluble Zaj Duab Xis
Tam sim no, cov yeeb yaj kiab dej ntau tshaj plaws hauv dej hauv lub ntiaj teb yog feem ntau dej-solubble PVA films. PVA yog Vinyl Polymer uas tuaj yeem siv tau los ntawm cov kab mob uas muaj cov roj carbon monoxide, thiab cov roj ua tau zoo, thiab cov khoom siv roj ua tsis tau zoo thiab roj teeb liab [4]. PVA Zaj duab xis muaj cov khoom siv zoo, muaj zog yoog thiab kev tiv thaiv zoo. Nws tau siv dav dav thiab muaj qib siab ntawm kev ua lag luam. Nws yog nyob deb ntawm feem ntau dav siv thiab cov dej loj tshaj plaws-solubble ntim zaj duab xis hauv kev ua lag luam [5]. PVA muaj qhov tsis zoo thiab tuaj yeem decomposab thiab tuaj yeem decomposed los ntawm cov kab mob me los tsim CO2 thiab H2O hauv av [6]. Feem ntau ntawm cov kev tshawb fawb txog cov yeeb yaj kiab dej-soluble cov yeeb yaj kiab tam sim no yog hloov kho thiab muab lawv kom tau txais cov yeeb yaj kiab zoo dua. Zhao linlin, Xiong Hanguo [7] Kawm txog PVA-soluby sim: Oxidized Starch (O-St) Tom qab microwave ziab ntawm cov yeeb yaj kiab tau txais, lub sijhawm ua dej-lub sijhawm hauv dej nyob rau hauv chav tsev kub yog 101s.
Kev txiav txim los ntawm cov xwm txheej tshawb tam sim no, PVA zaj duab xis tau siv dav, tus nqi tsawg, thiab zoo heev nyob rau ntau yam khoom. Nws yog qhov zoo tshaj plaws dej-solubble ntim cov khoom tam sim no. Txawm li cas los xij, raws li cov khoom siv roj av-raws li cov khoom siv, PVA yog cov khoom siv tsis txuas-ntxiv, thiab cov khoom siv tau khoom siv khoom siv. Txawm hais tias Tebchaws Asmeskas, Nyiv thiab lwm lub tebchaws tau teev nws yog cov tshuaj uas tsis muaj tshuaj lom, nws qhov kev nyab xeeb tseem qhib rau cov lus nug. Ob qho tib si inhalation thiab kev noj haus yog kev phom sij rau lub cev [8], thiab nws tsis tuaj yeem hu ua ua tiav cov khoos kas ntsuab.
1.1.2 polyethylene oxide (PEO) Dej-Soluble zaj duab xis
Polyethylene oxide, Kuj tseem yog polyethylene oxide, yog cov thermoplastic, dej-soluble polymer uas tuaj yeem sib xyaw nrog cov kev sib piv ntawm qhov kub thiab txias [9]. Cov txheej txheem cov qauv ntawm polyethylene oxide yog H - (- och2ch2-) n-huag, thiab nws tus txheeb ze cov molecular yuav cuam tshuam nws cov qauv. Thaum lub cev hnyav molecular yog nyob rau hauv thaj tsam ntawm 200 ~ 20000, nws yog hu ua polyethylene glycol (peg), thiab lub cev hnyav yog ntau dua 20,000 leej tuaj yeem hu rau polyethylene oxide (POO) [10]. Peo yog cov hmoov dawb granular, uas yooj yim rau cov txheej txheem thiab cov duab. Peo zaj duab xis feem ntau yog npaj los ntawm kev ntxiv cov tshuab yas, stabilizers thiab fillers rau Peo resins los ntawm thermopplastic ua [11].
Peing zaj duab xis yog dej zaj duab xis nrog cov dej solubility zoo tam sim no, thiab nws cov kev cuam tshuam qeeb, thiab feem ntau ntawm nws cov haujlwm tseem ceeb tuaj yeem siv tau. PVA Zaj Duab Xis Lwm Txoj Cai [12]. Tsis tas li ntawd, Peo kuj muaj qee qhov toxicity, yog li nws tsis tshua siv hauv cov ntim khoom [13].
1.1.3 Cov hmoov txhuv nplej siab-dej-soluble zaj duab xis
Cov hmoov txhuv nplej siab yog lub ntuj molecular polymer, thiab nws cov hmoov txhuv nplej siab ntawm cov hmoov txhuv nplej siab, thiab nws yog qhov nyuaj los cuam tshuam nrog lwm cov polymers. ua ke [14,15]. Cov dej solubility ntawm cov hmoov txhuv nplej siab yog tsis zoo, thiab nws siv sijhawm ntev, yog li cov hmoov txhuv nplej siab, feem ntau yog siv los npaj cov yeeb yaj kiab dej-soluble. Feem ntau, cov hmoov txhuv nplej siab tau hloov kho los ntawm cov hau kev xws li Etrerification, yog li kev txhim kho cov dej-solubility ntawm starch [7,16].
Qhia oveher pawg rau cov tsiaj txhuv nplej siab los yog siv cov hmoov txhuv nplej siab kom tau txais cov hmoov txhuv nplej siab [17], thiab kom tau txais dej-soluble starch nrog kev ua yeeb yaj kiab zoo dua. Txawm li cas los xij, ntawm tsawg kub, hmoov txhuv nplej siab muaj cov khoom siv tsis zoo thiab tsis zoo, nws yuav tsum tau npaj ua ke nrog lwm cov ntaub ntawv xws li PVA, thiab siv tus nqi tiag tiag tsis muaj txiaj ntsig.
1.1.4 protein-based dej-soluble nyias
Cov protein yog cov khoom siv muaj xyoob ntoo muaj txiaj ntsig macromolecular muaj nyob hauv cov tsiaj thiab nroj tsuag. Txij li cov tshuaj tiv thaiv protein feem ntau muaj cov dej hauv chav sov ntawm chav tsev nyob rau hauv chav tsev ntawm cov duab dhos ua yeeb yaj kiab nrog cov protein ua cov ntaub ntawv. Txhawm rau txhim kho cov solubility ntawm cov protein, lawv yuav tsum tau hloov kho. Cov tshuaj lom neeg cov qauv tshuaj suav nrog dephthalemination, phthaloamidation, phosphorylation, thiab lwm yam [18]; Cov txiaj ntsig ntawm kev hloov kho yog hloov pauv cov protein ntawm cov protein, yog li nce cov solubility, gelation, kev ua haujlwm xws li kev siv dej thiab kev ruaj khov raws li kev xav tau ntawm cov kev xav tau ntawm kev tsim khoom thiab kev tsim khoom. Protein-based dej-soluble cov yeeb yaj kiab tuaj yeem tsim los ntawm kev siv cov khoom lag luam muaj roj ntsha uas muaj cov tsiaj muaj zog, thiab cov ntaub ntawv tshwj xeeb hauv ib puag ncig [19]. Txawm li cas los xij, cov dej-solubble cov yeeb yaj kiab npaj los ntawm tib cov protein ua cov khoom siv hluav taws xob tsis zoo thiab kub thiab txias, yog li lawv daim ntawv thov ntau yog nqaim.
Txhawm rau kom suav, nws yog qhov tseem ceeb tshaj plaws los tsim kho tshiab, dej-doluble ntim zaj duab xis nrog kev ua tau zoo ntawm cov duab dej-soluble tam sim no.
HydroxyPropy cellulose (HydroxyPropy cellulose, HPMC luv, tsis muaj kuab, tsis muaj kev phom sij, thiab muaj cov peev txheej pheej sib tw, thiab muaj cov peev txheej qis dua hauv cov xwm txheej [20]]. Nws muaj cov dej zoo solubility thiab ua yeeb yaj kiab ua yeeb yam, thiab muaj cov xwm txheej rau kev npaj cov kua dej-soluble ntim cov yeeb yaj kiab.
1.2 HydroxyPropyY Metylcellulose
HydroxyPropy cellulose (hydroxypropyl cellulose, yog tau los ntawm kev kho mob ntawm lub ntuj, yog tau txais los ntawm kev kho mob ntuj, muab cov tshuaj tiv thaiv zoo nkauj thiab kev ntxuav cov txheej txheem. Dej-soluble cellulose derivative [21]. HydroxyPropyyl methylcellose muaj cov yam ntxwv hauv qab no:
(1) cov khoom muaj nuj nqis thiab rov ua dua tshiab. Cov khoom siv raw ntawm hydroxypropy yog qhov muaj ntau heev ntawm cellulose hauv ntiaj teb, uas yog rau cov khoom siv hauv ntiaj teb.
(2) ib puag ncig tus phooj ywg thiab biodegradable. HydroxyPropyyl methylulose yog tsis muaj tshuaj lom thiab tsis muaj kev phom sij rau tib neeg lub cev thiab tuaj yeem siv hauv tshuaj thiab khoom noj.
(3) ntau yam kev siv. Raws li cov dej-soluble cov khoom siv, hydroxypropylulose muaj cov khoom siv ua kom zoo, thiab khoom noj txhua yam, cov khoom siv hluav taws xob thiab muaj lwm daim teb [21].
1.2.1 qauv ntawm hydroxypropyl methylcellose
HPMC tau txais los ntawm cov ntaub ntawv ntawm lub ntuj tom qab kev sib dhos, thiab ib feem ntawm nws polyhydrropy thiab methyl tau epylene oxide thiab methyl chloride. Cov neeg ua lag luam HPM me me tau hloov pauv txawv ntawm 1.0 txog 2.0, thiab hydroxypropyl nruab nrab hloov degree hloov chaw ntawm 0.1 txog 1.0. Nws cov mis molecular muaj nyob hauv daim duab 1.1 [22]
Vim tias lub cev muaj zog hydrogen nruab nrab ntawm ntuj cellulose macromolecules, nws yog qhov nyuaj kom yaj hauv dej. Solubility ntawm Betherified Cellulose hauv dej yog ua rau pawg neeg hydrogules thiab nce rau cov solubility hauv dej [23]]. HydroxyPropyylencellulose (HPMC) yog ib pawg hydroxyalmans (shoco) pab pawg. - [OCH2CH (CH3) N H HE Hydroxyl pawg kawg thiab hydroxed acretated, uas muaj qee yam kev ua haujlwm sab hauv cov nyhuv zoo rau cov macromolecular saw; -Och3 yog ib pab pawg kawg, cov kev hloov pauv ntawm yuav tsis ua haujlwm, thiab nws yog pab pawg luv luv hydrophobic [21]. Cov pab pawg hydroxyl ntawm cov pawg ceg tshiab ntxiv thiab cov pawg hydroxyl uas tshuav tau hloov pauv ntawm cov pab pawg zoo nkauj thiab kho tau nyob rau hauv ib lub zog muaj zog [24].
1.2.2 Dej Solubility ntawm HydroxyPropyyl methylcellose
HydroxyPropyf methylcellulose muaj ntau cov khoom zoo vim tias cov qauv tshwj xeeb, cov uas tseem ceeb tshaj plaws ntawm uas yog nws cov dej solubility. Nws swells rau hauv cov tshuaj colloidal hauv dej txias, thiab kev daws teeb meem muaj qee qhov kev ua si saum npoo av, siab pob tshab thiab ruaj khov [21]. HydroxyPropyyl methylulose yog qhov tseeb lub cellulose tau txais kev hloov kho me me ntawm methylcellose zoo ib yam li cov dej me me [21], thiab nws cov dej solubility hauv dej tau txhim kho. Methyl cellulose yuav tsum tau muab tso rau ntawm 0 txog 5 ° C rau 20 rau 40 feeb kom tau txais cov tshuaj muaj nrog cov qauv zoo thiab ruaj khov viscosity [25]. Kev daws ntawm hydroxypropyl methylcellose cov khoom tsuas yog xav tau ntawm 20-25 ° C kom ua tiav cov ruaj khov zoo thiab zoo transparity thiab zoo transparency [25]. Piv txwv li, tus pulverized hydroxypropyl methylcellulose (granular duab 0.2-0.5 mm) tuaj yeem yooj yim tshaj plaws thaum lub viscosity ntawm 2000 centipoise ntawm 20 ° C.
1.2.3 Zaj duab xis tsim cov khoom ntawm hydroxypropyl methylculose
Hydroxypropy Kev daws teeb meem tau muaj cov yeeb yaj kiab zoo tshaj plaws, uas tuaj yeem muab cov txheej txheem zoo rau kev npaj tshuaj. Cov txheej txheem txheej yeeb yaj kiab tsim los ntawm nws yog xim tsis muaj kob, tsis muaj ntxhiab, tawv thiab pob tshab [21].
Yan Yanzhong [26] Siv kev sim tshuaj orthogonal los tshawb xyuas cov khoom ua yeeb yaj kiab ntawm hydroxypropylencellulose. Kev tshuaj ntsuam tau raug nqa tawm ntawm peb theem nrog ntau qhov ntau thiab cov kuab tshuaj sib txawv raws li yam. Cov txiaj ntsig tau pom tias ntxiv 10% Hydroxypropylulose rau hauv 50% kev daws teeb meem muaj cov khoom siv ua yeeb yaj kiab zoo tshaj plaws.
1.1 Kev hloov kho tau yooj yim ntawm hydroxypropyl methylcellulose zaj duab xis
Raws li cov khoom siv txuas ntxiv rau cov khoom siv txuas ntxiv, kev ua yeeb yaj kiab npaj los ntawm cov khoom siv raw tau muaj qhov ruaj khov ua ntej, thiab yog tsis muaj teeb meem, uas tsis muaj teeb meem rau ib puag ncig. Txawm li cas los xij, cov yeeb yaj kiab cellulose tsis tau muaj cov kev ua tsis zoo, thiab cellulose tuaj yeem muab cov yas thiab hloov kho.
[27] Siv triethyl citrate thiab acetyl tetrabutyl citrate ntxaij kom yas thiab hloov cellulose acetate propionate. Cov txiaj ntsig tau pom tias Elongation ntawm kev tawg ntawm lub cellulose acetate propionyl citrate thiab acetyl tetrabutyl citrate yog 10%.
Lua Al Pleve Ap [[28] kawm cov txiaj ntsig ntawm cov yas nkev, stearic acid thiab glucose ntawm cov khoom siv tshuab hluav taws xob ntawm methylcellulose membranes. Cov txiaj ntsig tau pom tias tus nqi elongation ntawm Methyl cellulose membrane tau zoo dua thaum cov ntsiab lus me me ntawm cov piam thaj thiab cov kua qaub yog 0.5%.
Glycerol yog ib qho tsis muaj kob, qab zib, meej, pleev kua nrog lub qab zib sov, feem ntau yog hu ua glycerin. Haum rau kev tsom xam ntawm cov kev daws teeb meem aqueous, cov kws ua haujlwm, thiab lwm yam tuaj yeem siv tau raws li cov roj lubricating roj kom zoo tawv. Sorbitol, cov hmoov dawb hygroscopic lossis crystalline hmoov, flakes lossis granules, tsw. Nws muaj cov haujlwm ntawm kev nqus dej noo thiab dej khaws cia. Ntxiv me ntsis hauv kev tsim tawm ntawm kev nqus cov pos hniav thiab cov khoom qab zib tuaj yeem ua kom cov khoom noj muag muag, txhim kho lub koom haum thiab txo lub luag haujlwm ntawm cov xuab zeb. Glycerol thiab sorbitol yog ob qho dej-soluble tshuaj, uas tuaj yeem sib xyaw nrog cov tshuaj tiv thaiv dej-soluble cellulose muaj kev pab muaj [23]. Lawv tuaj yeem siv tau cov tshuab yas rau cellulose. Tom qab kev ntxiv ntxiv, lawv tuaj yeem txhim kho hloov tau thiab elongation ntawm kev tawg ntawm cov yeeb yaj kiab cellulose. [29]. Feem ntau, cov concentration ntawm kev daws teeb meem yog 2-5%, thiab tus nqi ntawm cov yas muaj 10-20% ntawm cellulose ether. Yog tias cov ntsiab lus ntawm cov yas cua muaj siab dhau, qhov tsis txaus siab ntawm lub cev qhuav dej ntawm lub cev qhuav dej ntawm dryroid lub cev qhuav dej yuav tshwm sim ntawm qhov kub siab [30].
1.2 cov kev hloov pauv ntawm hydroxypropyl methylcellulose zaj duab xis
Cov yeeb yaj kiab dej-soluble muaj cov dej solubility zoo, tab sis nws tsis xav kom yaj nrawm thaum siv qee zaus, xws li cov noob ntim noob. Cov noob yog qhwv nrog zaj duab xis dej-soluble, uas tuaj yeem ua kom muaj sia nyob tus nqi ntawm cov noob. Nyob rau lub sijhawm no, txhawm rau tiv thaiv cov noob, nws tsis yog xav tias cov yeeb yaj kiab yuav yaj sai sai, tab sis zaj duab xis yuav tsum xub ua si qee cov nyhuv dej. Yog li ntawd, nws yog qhov tsim nyog yuav tsum tau ntev lub sijhawm dej-lub sijhawm ntawm zaj duab xis. [21].
Vim li cas hydroxypropyl methylcelulose muaj cov pab pawg ua kom zoo nkauj hauv hydroxulropyl tau txo qis, yog li txo cov dej solubility ntawm Lub hydroxypropy ua yeeb yaj kiab, thiab cov pab cuam tshuam sib txawv ntawm cov pab pawg hydroxyl thiab aldehydes yuav tsim ntau yam khoom siv ntawm cov yeeb yaj kiab ntawm zaj yeeb yaj kiab rau ib qho. Aldrohydes hla nrog hydroxypropylulose muaj xws li cov tshuaj tiv thaiv, thiab lwm yam, formaldehyde muaj ob pawg aldehyde tau nrawm, thiab glutaraldehyde yog cov tshuaj tua kab mob ntau. Nws yog kev nyab xeeb, yog li glutaraldehyde feem ntau yog siv los ua tus neeg sawv cev hla kev sib cav rau cov neeg ua kom muaj kev pab. Tus nqi ntawm hom ntawm no txuas-txuas tus neeg sawv cev hauv kev daws teeb meem yog feem ntau 7 txog 10% ntawm qhov hnyav ntawm Etaws. Kev kho ntsuas kub yog li 0 txog 30 ° C, thiab lub sijhawm yog 1 ~ 120 feeb [31]. Cov tshuaj tiv thaiv kev sib txuas hla kev xav tau yuav tsum tau ua raws li cov acidic. Ua ntej, ib qho inorganic cov kua qaub lossis cov organic carboxylic acid tau ntxiv txog 4-6, thiab tom qab ntawd aldehydes tau ntxiv los ua cov tshuaj tiv thaiv kab ntsig [32]. Cov kua qaub siv suav nrog HCL, H2SO4, acetic acid, citric acid, thiab zoo li. Cov kua qaub thiab Aldehyde tseem tuaj yeem ntxiv rau tib lub sijhawm kom daws tau cov tshuaj tiv thaiv kab ke sib txuas ntawm cov khoom xav tau ntawm cov qib siab.
1.3 antioxidative tej yam ntawm hydroxypropyl methylcellulose zaj duab xis
HydroxyPropyyl methylulose yog nplua nuj nyob rau hauv cov peev txheej, yooj yim rau daim ntawv qhia ua yeeb yaj kiab, thiab muaj cov nyhuv tshiab. Raws li cov khoom noj khoom haus khaws cia, nws muaj peev xwm txhim kho muaj peev xwm loj hlob [34-36].
Zhuang rongyu [37] siv hydroxypropylulose (HPMC) cov yeeb yaj kiab editib, thiab tom qab ntawd khaws nws cov nyhuv rau cov txiv lws suav thiab xim. Cov txiaj ntsig qhia tau hais tias lub hardness ntawm lws suav nrog HPMC txheej yog siab dua qhov tsis muaj txheej. Nws kuj tau muaj pov thawj tias HPMC tus yeeb yaj kiab tshiab yuav ncua cov xim hloov ntawm txiv lws suav los ntawm liab dawb rau 20 ℃.
[38] kawm txog cov kev cuam tshuam ntawm hydroxypropylulose (HPMC) synther kev ua si ntawm "Wuzhong" Bayberry txiv hmab txiv ntoo thaum lub sijhawm khoom txias. Cov txiaj ntsig tau pom tias anti-oxidation kev ua haujlwm ntawm Bayberry kho nrog HPMC zaj duab xis tau hloov dua, thiab cov txiaj ntsig ntawm 5% HPMC zaj duab xis yog qhov zoo tshaj plaws.
Wang Kaikai li al. [39] siv "Wuzhong" Bayberry txiv hmab txiv ntoo ua cov khoom ntsuas ntawm cov nyhuv ntawm cov txiaj ntsig zoo thiab cov tshuaj tiv thaiv hydrotharcelles ntawm kev cia ntawm 1 ℃. nyhuv ntawm kev ua si. Cov txiaj ntsig tau pom tias cov riboflavin-composite hpmc-coated bayberry txiv hmab txiv ntoo thaum lub sijhawm khaws cia, yog li ntev ntev lub sijhawm ntawm cov txiv hmab txiv ntoo.
Nyob rau hauv xyoo tsis ntev los no, tib neeg muaj cov tseev kom muaj siab dua thiab muaj siab dua rau kev nyab xeeb khoom noj. Cov kws tshawb nrhiav nyob rau hauv tsev thiab txawv teb tau maj mam hloov lawv cov kev tshawb fawb ua kom muaj txiaj ntsig los ntawm cov khoom noj ntxiv rau cov khoom ntim. Los ntawm kev ntxiv lossis txau tshuaj tiv thaiv antioxidants rau hauv cov ntaub ntawv ntim khoom, lawv tuaj yeem txo cov zaub mov oxidation. Cov nyhuv ntawm kev lwj tus nqi [40]. Cov tshuaj tiv thaiv ntuj muaj kev txhawj xeeb dav vim yog lawv cov kev nyab xeeb thiab muaj kev nyab xeeb rau tib neeg lub cev [40,41].
Antioxidant ntawm xyoob nplooj (Aob luv luv) yog antioxidant nrog cov xyoob ntoo nqaij daim tawv nqaij thiab cov dej ua kom zoo. Nws tau teev nyob hauv lub teb chaws tus qauv GB2760 thiab tau pom zoo los ntawm Ministry of Health ua antioxidant rau cov zaub mov ntuj. Nws kuj tseem tuaj yeem raug siv ua khoom noj ntxiv rau cov nqaij ua nqaij, cov khoom lag luam dej muaj dej thiab cov zaub mov puffed [42].
Tshav Lina thiab lwm yam [42] Rov xyuas lub ntsiab ntawm cov khoom siv tseem ceeb thiab cov khoom lag luam ntawm xyoob ntoo antioxidants thiab qhia txog ntawm xyoob ntoo antioxidants hauv cov khoom noj. Ntxiv 0.03% AOB rau tshiab mayonnaise, cov nyhuv antioxidant yog qhov pom tseeb tshaj plaws nyob rau lub sijhawm no. Piv nrog tib tus nqi ntawm cov tshuaj yej polyphenol antioxidants, nws cov nyhuv antioxidant yog obviously zoo dua li ntawm cov tshuaj yej polyphenols; Ntxiv 150% mus rau npias ntawm mg / u, antioxidant thaj chaw thiab kev ruaj khov nce, thiab npias muaj qhov zoo sib xws nrog lub khob cawv. Thaum ua kom cov qub zoo ntawm cov kua dej caw, nws kuj tseem ua rau tus ntxhiab tsw qab dev thiab mellow ntawm xyoob nplooj [43].
Hauv cov ntsiab lus, hydroxypropyl methylcellose muaj cov yeeb yaj kiab zoo-tsim cov khoom thiab kev ua tau zoo heev. Nws tseem yog cov ntaub ntawv ntsuab thiab tsis pom zoo, uas tuaj yeem siv los ua cov yeeb yaj kiab ntim hauv kev ntim [44-48]. Glycerol thiab Sorbitol yog ob lub tshuab dej-soluble. Ntxiv cov glycerol lossis sorbitol mus rau lub cellulose kev daws teeb meem ntawm hydroxyprosylulose zaj duab xis, yog li nce mus elongation ntawm kev ua yeeb yaj kiab [49-51]. Glutaraldehyde yog cov tshuaj tua kab mob ntau. Piv nrog rau lwm cov aldehydes, nws kuj muaj kev nyab xeeb, thiab muaj ib pab neeg sib tham hauv cov molecule, thiab cov ntoo khaub lig-txuas nrawm yog qhov nrawm. Nws tuaj yeem raug siv ua cov kev hloov pauv ntawm hydroxypropyl methylulose zaj duab xis. Nws tuaj yeem hloov cov dej solubility ntawm zaj duab xis, kom cov zaj duab xis tuaj yeem siv tau ntau zaus [52-55]. Ntxiv xyoob nplooj antioxidants rau hydroxypropylulose cov yeeb yaj kiab los txhim kho cov duab antioxyproplecelyl metylropylulose zaj duab xis thiab nthuav nws daim ntawv thov hauv ntim zaub mov.
1.4 Cov lus thov ntawm lub ncauj lus
Los ntawm cov xwm txheej tshawb nrhiav tam sim no, cov yeeb yaj kiab dej yog suav nrog PVA zaj duab xis, Peo zaj duab xis, Psarch-raws li cov yeeb yaj kiab-soluble. Raws li cov khoom siv roj av-raws li cov khoom siv, PVA thiab PICO tsis yog cov peev txheej tsis muaj dua tshiab, thiab cov txheej txheem ntau lawm ntawm lawv cov khoom siv raw yuav muaj kuab paug. Txawm hais tias Tebchaws Asmeskas, Nyiv thiab lwm lub tebchaws tau teev nws yog cov tshuaj uas tsis muaj tshuaj lom, nws qhov kev nyab xeeb tseem qhib rau cov lus nug. Ob qho tib si inhalation thiab kev noj haus yog kev phom sij rau lub cev [8], thiab nws tsis tuaj yeem hu ua ua tiav cov khoos kas ntsuab. Cov txheej txheem ntau lawm ntawm cov hmoov txhuv nplej siab thiab cov khoom siv protein-based ntawm cov khoom muaj kev phom sij thiab muaj kev nyab xeeb ntawm kev nyuaj zaj duab xis, qis elongation, thiab yooj yim tawg. Yog li ntawd, feem ntau, lawv yuav tsum tau npaj los ntawm kev sib xyaw nrog lwm cov ntaub ntawv xws li PVA. Tus nqi siv tsis yog siab. Yog li ntawd, nws yog qhov tseem ceeb tshaj plaws los tsim kho tshiab, kev ntim dej-dej-qhuav los txhim kho qhov tsis xws luag ntawm cov yeeb yaj kiab dej.
HydroxyPropyyl methylulose yog lub ntuj polymer cov khoom, uas tsis yog kev nplua nuj nyob hauv cov peev txheej, tab sis kuj txuas ntxiv mus ntxiv. Nws muaj cov dej zoo solubility thiab ua yeeb yaj kiab ua yeeb yam, thiab muaj cov xwm txheej rau kev npaj cov kua dej-soluble ntim cov yeeb yaj kiab. Yog li no, daim ntawv no npaj los npaj hom dej tshiab-soluble ntim medylropylulose li cov khoom siv raw, thiab sib piv, thiab ntxiv cov roj hmab tsim nyog (glycerol thiab sorbitol). ), hla kev sib txuas (glutaraldehyde), antioxidant (xyoob ntoo antioxidrop nrog cov khoom siv kho tshuab xws li cov khoom siv kho tshiab, txhawm rau txhim kho cov khoom siv kho kom zoo dua li cov khoom siv hluav taws xob, cov dej solubility, cov dej solubility thiab antioxidant thaj chaw. Methylcellulose dej-soluble ntim zaj duab xis yog qhov tseem ceeb tshaj plaws rau nws cov ntawv thov ua cov dej-solubble ntim cov khoom siv.
1.5 Cov ntsiab lus tshawb nrhiav
Cov ntsiab lus tshawb fawb yog raws li hauv qab no:
1) HPMC Dej-Soluble Ntim Zaj Duab Xis tau npaj los ntawm kev daws teeb meem kev ua yeeb yaj kiab thiab cov yeeb yaj kiab ntawm kev ua yeeb yam ntawm HPMC Dej-Soluble ntim zaj duab xis.
2) Los kawm cov txiaj ntsig ntawm glycerol thiab sorbitol tshuab yas ntawm cov cuab yeej siv tshuab, cov dej solubility thiab kho dua tshiab ntawm HPMC dej-soluble ntim cov yeeb yaj kiab.
3) Los kawm txog cov nyhuv ntawm glutaraldehyde hla tus neeg sawv cev rau cov dej solubility, cov khoom siv tshuab thiab kho tau ntawm HPMC Dej-Soluble Ntim Cov Yeeb Yaj Kiab.
4) Kev npaj ntawm aob / hpmc dej-soluble ntim zaj duab xis. Cov oxidation tiv taus, dej solubility, cov khoom siv mechanical, cov tshuab siv tshuab thiab kho qhov muag ntawm Aob / HPMC nyias cov yeeb yaj kiab tau kawm.
Tshooj 2 Npaj thiab cov khoom ntawm hydroxypropyl methylropyf me me cov dej cellulose dej-soluble ntim zaj duab xis
2.1 Kev Taw Qhia
HydroxyPropyyl methylulose yog lub ntuj cellulose derivative. Nws yog tsis muaj tshuaj lom, tsis muaj kuab paug, txuas dua tshiab, thiab muaj dej so thiab ua yeeb yaj kiab zoo nkauj. Nws yog qhov muaj peev xwm dej-solubble ntim cov khoom ua ntej.
Tshooj lus no yuav siv HydroxyPropyyl methylcellose li cov khoom siv roj hmab los ntawm kev daws teeb meem kev ua yeeb yam ntawm cov duab ua yeeb yam, thiab ua yeeb yaj kiab siv rau cov yeeb yaj kiab. Lub zog crystalline ntawm zaj duab xis tau cim los ntawm X-Ray kev hloov chaw, kev sib txuas lus ntawm lub zog, kev sib txuas ntawm cov dej thiab dej-solubility kuaj degree thiab dej solubility.
2.2 Kev sim sim
2.2.1 Kev sim cov khoom siv thiab cov twj siv
2.2.2 Kev Npaj Ua Quav
1) Kev hnyav: hnyav me me ntawm hydroxypropyl methylulose nrog hluav taws xob sib npaug.
2) Kev Tawm Tsam: Ntxiv lub siab HydroxyPropyyl nrho methylropylulose rau lub sijhawm deionized, thiab siab kom nws sawv ntsug rau ib lub sijhawm (defoaming) kom tau txais qee qhov kev sib xyaw. membrane kua. Tsim ntawm 2%, 3%, 4%, 5% thiab 6%.
3) Zaj duab xis: ① Npaj cov yeeb yaj kiab nrog cov tshuaj sib txawv ntawm cov tshuaj sib txawv ntawm 40 ~ 50 ° C kom qhuav thiab ua cov yeeb yaj kiab. Lub hydroxypropyl methylcellulose dej-soluble ntim zaj duab xis nrog lub thickness ntawm 25-50 μm tau npaj, thiab muab tso rau hauv lub thawv kom qhuav rau siv. Ua kom muaj cov yeeb yaj kiab nyias nyias ntawm cov yeeb yaj kiab sib txawv-ua kom sov (30 ~ 70 ° C) zaj yeeb yaj kiab tau qhuav hauv qhov cub cua qhuav. Lub hydroxypropyf methylcellulose dej-soluble ntim zaj duab xis nrog ib tug tuab ntawm kwv yees li 45 μm tau npaj thiab muab tso rau hauv lub thawv kom qhuav rau siv. Qhov npaj hydroxypropyl methylropenose dej-soluble ntim zaj duab xis yog hu ua HPMC zaj duab xis rau luv.
2.2.3 Ceeb toom thiab ntsuas kev ntsuas
2.2.3.1 dav-lub kaum ntse ntse x-ray diffraction (xrd) tsom xam
Dav xoo hluav taws xob xoo hluav taws xob sib txawv (XRD) tsom xam lub xeev crystalline ntawm cov khoom ntawm qib molecular. Lub X-tshav teb diffracometer ntawm Arl / Xtra Hom tsim los ntawm Thermo Arl Company hauv kev txiav txim siab. Kev ntsuas kev ntsuas: Lub X-ray qhov chaw yog ib npib tsib xee-lim cu-kα kab (40kv, 40mA). Lub scan kaum sab xis yog los ntawm 0 ° txog 80 ° (2θ). Kev luam tawm ceev 6 ° / min.
2.2.3.2 Cov Khoom Siv Neeg Kho Tshuab
Lub zog tensile thiab elongation ntawm kev tawg ntawm zaj yeeb yaj kiab yog siv los ua cov qauv kev ntxhov siab (tensile lub zog (thiab chav tsev yog MPa. Elongation thaum tawg (tawg elongation) yog hais txog qhov sib piv ntawm elongation thaum zaj yeeb yaj kiab tau tawg rau qhov ntev ntev, qhia hauv%. Siv cov khoom siv me me (5943) Hom Tshuaj Hluav Taws Xob Ntau Yam ntawm cov khoom siv yas, raws li cov khoom siv yas, raws li cov khoom siv sib xyaw nrog cov khoom siv yas yam tsis muaj kev sim.
2.2.3.3 Optical Cov Khoom
Qhov ntsuas kho qhov muag yog qhov taw qhia tseem ceeb ntawm cov pob tshab ntim ntawm ntim cov yeeb yaj kiab, feem ntau yog suav nrog kev hloov pauv thiab kub ntawm zaj duab xis. Kev hloov pauv thiab kub ntawm cov yeeb yaj kiab tau ntsuas siv cov kev hloov pauv Haze Taleer. Xaiv cov qauv ntsuas nrog cov npoo huv thiab tsis muaj kev sib tsoo, kho nws nrog kev sib txuas lus, thiab ntsuas nws nrog cov yeeb yaj kiab ntawm chav tsev kub (25 ° C thiab 50% Rh). Qhov qauv yog sim 3 zaug thiab tus nqi nruab nrab yog coj.
2.2.3.4 DEJ Solubility
Txiav ib lub 30 hli × 30mm zaj duab xis nrog lub tuab ntawm li 45μm, ntxiv 100ml beaker, thiab ntsuas lub sijhawm rau kev ua yeeb yaj kiab kom ploj tag [56]. Txhua qhov hnoos tau ntsuas 3 zaug thiab tus nqi nruab nrab tau coj, thiab chav tsev yog min.
2.2.4 Cov ntaub ntawv ua haujlwm
Cov ntaub ntawv sim tau ua tiav los ntawm Excel thiab plotted los ntawm keeb kwm software.
2.3 Cov Ntsiab Lus thiab Kev Sib Tham
2.3.1.1 xrd qauv ntawm HPMC nyias cov yeeb yaj kiab nyob rau hauv cov yeeb yaj kiab sib txawv-kev daws cov tshuaj muaj zog
Fig.2.1 xrd ntawm HPMC zaj duab xis nyob rau hauv cov ntsiab lus sib txawv ntawm HP
Dav-lub xoo hluav taws xob xoo diffraction yog kev soj ntsuam ntawm lub xeev crystalline ntawm cov tshuaj ntawm theem molecular. Daim duab 2.1 Yog cov qauv xrd diffraction ntawm HPMC nyias zaj duab xis nyob rau hauv cov yeeb yaj kiab sib txawv. Muaj ob qho diffraction peaks [57-59] (ze rau 9.5 ° thiab 20.4 ° thiab 20.4 ° thiab 20.4 ° thiab 20.4 ° thiab 20.4 ° thiab 20.4 ° thiab 20.4 °) hauv daim duab HPMC hauv daim duab. Nws tuaj yeem pom los ntawm daim duab uas nrog kev nce HPMC, cov yeeb yaj kiab txawv ntawm lub HPMC zaj duab xis nyob ib ncig ntawm 9.5 ° thiab 20.4 ° yog ua ntej txhim kho. Thiab tom qab ntawd tsis muaj zog, cov degree ntawm molecular kev npaj (xaj kom tiav) thawj zaug nce thiab tom qab ntawd poob. Thaum cov kev xav tau yog 5%, cov txheej txheem txheej txheem ntawm HPMC lwg me me yog qhov zoo tshaj plaws. Qhov laj thawj rau cov xwm txheej saum toj no yuav yog qhov uas nce HPMC kev pom zoo, yog li ua HPM molecular ntau yam. Thaum HPMC concentration ntau dua 5%, XRD diffraction ncov ntawm zaj duab xis tsis muaj zog. Los ntawm qhov pom ntawm cov molecular charment, thaum lub HPMC concentress yog loj heev, lub viscosity ntawm zaj duab xis kev daws teeb meem los mus thiab tsis tuaj yeem npaj rau lub sijhawm, yog li ua rau muaj kev txiav txim HPMC ntawm HPMC cov yeeb yaj kiab txo.
2.3.1.2 Cov khoom siv neeg kho tshuab ntawm HPMC nyias cov yeeb yaj kiab nyob rau hauv cov yeeb yaj kiab sib txawv-kev daws teeb meem.
Lub zog tensile thiab elongation ntawm kev tawg ntawm zaj duab xis yog siv los ua cov qauv rau kev ntxhov siab thaum lub tshav xis tsim cov khaub ncaws loj tshaj plaws. Qhov elongation thaum so yog qhov sib piv ntawm qhov kev hloov chaw rau tus thawj ntev ntawm zaj duab xis ntawm so. Kev ntsuas ntawm cov neeg kho tshuab ntawm zaj yeeb yaj kiab muaj peev xwm txiav txim nws cov ntawv thov hauv qee thaj teb.
Fig.2.2 Cov nyhuv ntawm cov ntsiab lus sib txawv ntawm HPMC ntawm cov khoom siv tshuab ntawm HPMC cov yeeb yaj kiab
Los ntawm Daim duab 2.2, hloov pauv hloov ntawm Tensile muaj zog thiab elongation ntawm kev sib tw HPMC, nws tuaj yeem pom tau tias kev ua kom muaj zog ntawm HPMC-kev daws teeb meem. Thaum kev daws teeb meem yog 5%, cov khoom siv mechanories ntawm HPMC zaj duab xis zoo dua. Qhov no yog vim tias thaum zaj yeeb yaj kiab ua kua yog qhov tsawg, kev sib cuam tshuam nrog lub peev xwm ntawm cov yeeb yaj kiab, thiab cov molestallization muaj peev xwm tsawg thiab nws cov yam ntxwv tsis zoo; Thaum cov yeeb yaj kiab-tsim cov kua siv yog 5%, cov cuab yeej siv tshuab ncav cuag tus nqi. Raws li cov concentration ntawm zaj duab xis-ua kua txuas ntxiv, lub casting thiab ntau dua qhov tsis zoo ntawm cov khoom HPMC thiab ntau qhov kev txo qis hauv HPMC zaj duab xis. Yog li ntawd, cov concentration ntawm 5% hpmc-kev daws teeb meem yog qhov haum tshaj plaws. Cov kev ua tau zoo ntawm cov yeeb yaj kiab tau txais tseem zoo dua.
2.3.1.3 Optical cov khoom ntawm HPMC nyias cov yeeb yaj kiab nyob rau hauv cov yeeb yaj kiab sib txawv-ua kom muaj kev daws teeb meem
Hauv cov yeeb yaj kiab ntim khoom, teeb pom kev hloov pauv thiab kub kub yog qhov tseem ceeb qhia tau qhov pob tshab ntawm zaj duab xis. Daim duab 2.3 Qhia txog kev hloov pauv hloov pauv ntawm kev hloov pauv thiab khaus ntawm HPMC zaj duab xis nyob rau hauv cov yeeb yaj kiab ua yeeb yaj kiab ua kua. Nws tuaj yeem pom los ntawm daim duab uas nrog kev nce ntawm cov kev sib xyaw HPMC-kev sib txuas lus ntxiv nrog kev nce ntawm cov kev sib xyaw ntawm zaj duab xis.
Fig.2.3 Cov txiaj ntsig ntawm cov ntsiab lus sib txawv ntawm HPMC ntawm cov cuab yeej kho qhov muag ntawm HPMC cov yeeb yaj kiab
Muaj ob qho laj thawj: Ua ntej, los ntawm qhov kev pom ntawm cov kev sib koom tes ntawm cov sij hawm dispersed ntawm cov kev xav tau qis, tus lej concentration muaj cov khoom siv kho tshiab ntawm cov khoom siv [61]. Yog li ntawd, nrog kev nce ntawm kev xav ntawm HPMC zaj duab xis-ua cov tshuaj, cov yeeb yaj kiab cov qauv ua kom tsawg. Cov kev hloov chaw teeb pom kev kom tsawg, thiab cov ntxau taws kub npau tau ntau. Thib ob, los ntawm kev tsom xam ntawm cov txheej txheem ua liaj ua teb, nws yuav yog vim tias zaj duab xis tau tsim los ntawm kev daws teeb meem casting zaj duab xis-txoj kev ua yeeb yaj kiab. Qhov nce ntawm kev nyuaj ntawm elongation ua rau txo qis ntawm cov zaj duab xis thiab txo ntawm cov khoom siv kho tshiab ntawm HPMC zaj duab xis.
2.3.1.4 Dej solubility ntawm hpmc nyias zaj duab xis nyob rau hauv cov yeeb yaj kiab sib txawv
Cov dej ua yeeb yaj kiab ntawm cov dej-soluble cov yeeb yaj kiab yog hais txog lawv cov yeeb yaj kiab-sib sau ua ke. Txiav tawm 30mm × 30mm films ua nrog cov yeeb yaj kiab sib txawv, thiab kos zaj duab xis nrog "+" los ntsuas lub sijhawm rau kev ua yeeb yaj kiab kom ploj mus. Yog tias cov yeeb yaj kiab daim ntaub lossis cov ntoo rau ntawm cov phab ntsa ntawm lub beaker, rov ua dua. Daim duab 2.4 yog cov qauv txheej txheem ntawm cov dej solubility ntawm HPMC zaj duab xis nyob rau hauv cov yeeb yaj kiab sib txawv-ua kom muaj cov yeeb yaj kiab sib txawv. Nws tuaj yeem pom los ntawm daim duab uas nrog kev nce ntawm zaj duab xis-ua kua rau HPMC, qhia tias cov dej solubility ntev dua. Nws yog speculated hais tias vim li cas thiaj li yog qhov nce ntawm kev daws teeb meem, thiab kev sib tw ntawm kev sib txawv ntawm HPMC zaj duab xis hauv dej thiab txo qis hauv dej solubility.
Fig.2.4 Cov txiaj ntsig ntawm cov ntsiab lus sib txawv ntawm HPMC ntawm cov dej solubility ntawm HPMC Films
2.3.2 Cov khawv koob ntawm zaj duab xis tsim cov kub ntawm HPMC nyias cov yeeb yaj kiab
2.3.2.1 xrd qauv ntawm HPMC nyias cov yeeb yaj kiab ntawm cov yeeb yaj kiab sib txawv ua qhov kub
Fig.2.5 XRD ntawm HPMC cov yeeb yaj kiab nyob rau hauv zaj duab xis sib txawv raws li kub
Daim duab 2.5 Qhia cov qauv xrd ntawm HPMC nyias cov yeeb yaj kiab ntawm cov yeeb yaj kiab sib txawv. Ob qho kev sib txawv sib txawv ntawm 9.5 ° thiab 20.4 ° tau tshawb xyuas rau HPMC zaj duab xis. Los ntawm qhov kev xav ntawm kev siv ntawm cov kev sib txawv, nrog kev nce ntawm zaj duab xis-ua qhov kub ua ntej, thiab tom qab ntawd crystallization muaj peev xwm ua ntej nce thiab tom qab ntawd poob. Thaum cov yeeb yaj kiab ua yeeb yaj kiab yog 50 ° C, qhov kev txiav txim ntawm HPMC lwg me me ntawm cov kev daws teeb meem ntawm kev siv cov roj crystal ntawm cov siv lead ua luaj, thiab cov crystallization yog qhov nyuaj; Raws li zaj duab xis ua kom sov maj mam nce, tus nqi ntawm nucleation tau yooj yim, thiab nws yooj yim dua los ntawm kev ua kom yooj yim, thiab nws yooj yim dua los ntawm cov roj crystall, thiab nws yooj yim dua los ua kom tau yooj yim rau cov nqi siab tshaj plaws ntawm ib qho kub siab; Yog hais tias zaj duab xis tsim kub dhau lawm, cov lus qhuab qhia molecular yog qhov nyuaj, thiab nws yog qhov nyuaj rau daim muaju [62,63]. Yog li no, crystallinity ntawm HPMC cov yeeb yaj kiab nce ua ntej thiab tom qab ntawd txo qis nrog kev nce ntawm zaj duab xis ua kom kub.
2.3.2.2 Cov khoom siv neeg kho tshuab ntawm HPMC nyias cov yeeb yaj kiab ntawm cov yeeb yaj kiab sib txawv
Cov kev hloov ntawm zaj duab xis ua kev sib sau ntsuas kub yuav muaj qee qhov kev cuam tshuam ntawm cov khoom siv me me ntawm cov yeeb yaj kiab. Daim duab 2.6 Qhia cov qauv hloov ntawm tensile muaj zog thiab elongation ntawm kev tsoo HPMC cov yeeb yaj kiab ntawm zaj duab xis sib txawv. Nyob rau tib lub sijhawm, nws tau pom tias yog tus qauv ntawm nce ua ntej thiab tom qab ntawd txo qis. Thaum cov yeeb yaj kiab sib dhos yog 50 ° C, lub zog tensile thiab elongation ntawm kev so ntawm HPMC zaj duab xis tau txog qhov tseem ceeb tshaj plaws, uas yog 116 MPA thiab 32%, feem.
Fig.2.6 Cov nyhuv ntawm zaj duab xis sib nyiam qhov kub ntawm cov khoom siv neeg kho tshuab ntawm HPMC Films
Los ntawm cov kev pom ntawm cov kev qhia molecular, ntau dua qhov kev npaj ua kom zoo ntawm lwg me me, qhov zoo dua lub tensile lub zog [64]. Los ntawm Daim duab 2.5 xrd qauv ntawm HPMC cov yeeb yaj kiab ntawm kev sib txawv ntawm zaj duab xis, nws tuaj yeem pom tau tias nrog kev nce qib HPMC ua ntej nce thiab tom qab ntawd txo qis. Thaum zaj duab xis tsim kev kub ntxhov yog 50 ° C, qib kev txiav txim siab loj tshaj plaws thiab tom qab ntawd muaj txiaj ntsig zoo tshaj plaws ntawm HPMC zaj duab xis ua ntej kub, thiab muaj txiaj ntsig siab tshaj plaws tshwm sim ntawm zaj duab xis tsim kub ntawm 50 ℃. Qhov elongation ntawm kev tawg qhia cov qauv ntawm kev nce qib ua ntej thiab tom qab ntawd txo qis. Qhov laj thawj yuav yog qhov ntsuas kub, qhov kev ua tiav crystalline ua ntej thiab tom qab ntawd cov qauv ua tiav, thiab tom qab ntawd cov qauv ua tiav crystalline tau tsim nyob rau hauv cov uncrystallized polymer matrix. Nyob rau hauv Matrix, lub cev ntoo khaub ncaws sib txuas yog tsim, uas ua rau muaj lub luag haujlwm ntawm HPMC kom tshwm sim lub ncov ntawm zaj duab xis ua kom sov ntawm 50 ° C.
2.3.2.3 Optical cov khoom ntawm HPMC cov yeeb yaj kiab ntawm cov yeeb yaj kiab sib txawv ua kom kub
Daim duab 2.7 yog qhov kev hloov pauv ntawm cov khoom siv kho qhov muag ntawm HPMC cov yeeb yaj kiab ntawm cov yeeb yaj kiab sib txawv. Nws tuaj yeem pom los ntawm daim duab uas nrog kev nce ntawm zaj duab xis ua kom sov, thiab cov khoom siv kho tau ntawm HPMC zaj duab xis maj mam ua zoo dua.
Daim duab.2.7 Cov nyhuv ntawm zaj duab xis sib sau ntsuas kub ntawm cov khoom kho kho ntawm HPMC
Raws li cov cawv ntawm qhov kub thiab dej lwg nyob rau ntawm zaj duab xis [66], thaum qhov ntsuas dej qis, thiab HPMC yog nyob rau hauv lub xeev lub xeev. Qhov chaw dawb ntawm zaj duab xis qhov hauv HPMC, thiab tom qab ntawd tawg yog tsim nyob rau ntawm lub qhov ua yeeb yaj kiab tom qab qis thiab npau taws heev; Raws li qhov kub nce ntxiv, cov pob zeb roj ntawm HPMC pib txav chaw, cov qhov kev hloov pauv tom qab cov yeeb yaj kiab zuj zus thiab cov pa taws txo.
2.3.2.4 Dej solubility ntawm HPMC cov yeeb yaj kiab ntawm cov yeeb yaj kiab sib txawv ua kom kub
Daim duab 2.8 qhia tias cov dej solubility nkhaus nkhaus ntawm HPMC cov yeeb yaj kiab ntawm cov yeeb yaj kiab sib txawv. Nws tuaj yeem pom los ntawm daim duab hais tias cov dej solubility lub sij hawm ntawm cov yeeb yaj kiab HPMC nce nrog kev nce kub, uas yog, dej solubility ntawm HPMC cov yeeb yaj kiab zoo dua li. Nrog rau kev nce ntawm zaj duab xis-sau cov ntsuas kub, kev txav mus los yog nrawm dua, cov molecular kis tau txo qis, thiab cov molecular plasted, thiab cov molecular tus nqi yog ntau dua, cov kev ua kom nrawm nrawm, cov khoom sib zog ntawm cov lwg me me kom nkag rau hauv HPMC lwg me me. Dej solubility kuj tseem raug txo.
Daim duab.2.8 Cov nyhuv ntawm zaj duab xis sib sau ntsuas kub ntawm cov dej solubility ntawm HPMC zaj duab xis
2.4 Cov ntsiab lus ntawm tshooj no
Hauv tshooj no, HydroxyPropyyl methylcellose tau siv los ua cov khoom siv ua haujlwm los npaj hpmc dej ntim cov zaj duab xis-ua yeeb yaj kiab. Lub crystallinity ntawm HPMC zaj duab xis tau txheeb xyuas los ntawm XRD qhov txawv; Cov khoom siv me me ntawm HPMC dej ntim cov zaj duab xis tau sim thiab tshuaj xyuas cov yeeb yaj kiab microc.c yog portalyzed los ntawm lub teeb xa kev xa cov tshuaj ntsuam ntawm Haze ntsuas. Lub sijhawm ua tiav hauv dej (cov kua txiv solubility) yog siv los tshuaj xyuas nws cov dej solubility. Cov lus xaus nram qab no yog kos los ntawm kev tshawb fawb saum toj no:
1) Cov khoom siv tshuab ntawm HPMC ua ntej nce thiab tom qab ntawd txo qis ntawm cov yeeb yaj kiab-kev nce thiab tom qab ntawd txo qis ntawm cov yeeb yaj kiab ua kom sov. Thaum cov concentration ntawm HPMC kev daws teeb meem yog 5% thiab cov yeeb yaj kiab-tsim kub yog 50 ° C, cov khoom siv me me ntawm zaj duab xis yog qhov zoo. Lub sijhawm no, lub zog tensile yog li 116MPA, thiab elongation thaum tawg yog li 31%;
2) Lub zog kho qhov muag ntawm HPMC cov yeeb yaj kiab txo qis nrog kev nce ntawm cov zaj duab xis-thiab maj mam nce nrog kev nce ntawm zaj duab xis-ua qhov kub thiab txias; Kev nkag siab tias kev sib haum xeeb ntawm zaj duab xis-ua cov tshuaj yuav tsum tsis pub tshaj 5%, thiab zaj duab xis-ua kom sov yuav tsum tsis pub tshaj 50 ° C
3) cov dej solubility ntawm HPMC cov yeeb yaj kiab qhia tau ib qho kev sib txuam hauv qab nrog kev ua kom muaj kev sib haum xeeb ntawm cov yeeb yaj kiab thiab kev ua yeeb yaj kiab ua yeeb yam kub. Thaum cov concentration ntawm 5% HPMC kev sib xyaw ua ke thiab cov yeeb yaj kiab-ua kom sov ntawm 50 ° C tau siv, dej-dissolving lub sij hawm ntawm zaj duab xis yog 55 min.
Tshooj 3 Cuam Tshuam ntawm cov tshuab yas ntawm HPMC dej-soluble ntim cov yeeb yaj kiab
3.1 qhia
Ua ib hom tshiab ntawm cov khoom siv polymer hpmc dej-soluble ntim zaj duab xis muaj qhov kev tsim kho kev tsim kho zoo. HydroxyPropyyl methylulose yog lub ntuj cellulose derivative. Nws tsis yog-lom, tsis muaj kuab paug, rov txuas dua tshiab, ruaj khov, thiab muaj cov khoom zoo. Dej-soluble thiab zaj duab xis-kev sib sau, nws yog qhov muaj peev xwm dej-solubble ntim cov khoom ua ntej.
Cov tshooj dhau los tham txog kev npaj Holmb-soluble ntim zaj duab xis thiab zaj dab neeg ntawm zaj duab xis ua kua los ntawm kev ua yeeb yaj kiab ua yeeb yaj kiab ntawm hydroxyprropylulose dej-soluble ntim zaj duab xis. Kev cuam tshuam ua tau zoo. Cov txiaj ntsig qhia tau hais tias lub zog ntawm zaj yeeb yaj kiab yog li 116MPA thiab Elongation thaum tawg thiab txheej txheem kev mob. Qhov nyuaj ntawm cov yeeb yaj kiab zoo li no tsis zoo hauv qee cov ntawv thov thiab xav tau kev txhim kho ntxiv.
Hauv tshooj no, HydroxyPropyyl methylcellulose tseem siv los ua cov khoom siv raw, thiab cov dej-solubble ntim zaj duab xis yog npaj los ntawm kev daws teeb meem casting yeeb yaj kiab. , elongation thaum tawg), kho qhov muag (hloov chaw (kev hloov pauv, kub hnyiab) thiab dej solubility.
3.2 Kev sim sim
3.2.1 sim cov ntaub ntawv thiab cov twj siv
Cov Ntawv 3.1 Kev Tshawb Fawb Cov Ntaub Ntawv thiab Cov Lus Qhia Tshwj Xeeb
Rooj 3.2 Kev sim seev thiab specifications
3.2.2 KUAPT ERIPs
1) Kev hnyav: hnyav me ntsis ntawm hydroxypropylulose (5%, 0.25%, 0..15%, 0.25%, 0.45%).
2) Kev Tawm Tsam: Ntxiv lub siab HydroxyPropylulose dej, thiab lub siab kom txog thaum nws tau ntxiv glycerol lossis sorbitol hauv ntau feem ntau ib feem. Nyob rau hauv hydroxypropylulose tshuaj methylculose, do lub sijhawm kom nws sawv ntsug li 5 feeb (defoosing) kom tau qee qhov kev xav ntawm zaj duab xis-ua kua.
3) zaj duab xis ua: txhaj cov kua zaj duab ua kua rau hauv ib lub khob ua kom qhuav thiab muab tso rau hauv lub ntsej muag kom qhuav thiab ua ib zaj duab xis los ua ib zaj duab xis nrog ib daim duab tuab nrog ib qho tuab ntawm 45 μm. Tom qab zaj duab xis tau muab tso rau hauv lub thawv kom qhuav rau siv.
3.2.3 Ceeb tsheej thiab kev sim ua haujlwm
3.2.3.1 Infrared nqus spectroscopy (FT-i ir) tsom xam
Infrared nqus spectroscopy (FTIR) yog ib txoj kev muaj zog rau cov pab pawg ua haujlwm muaj nyob hauv cov qauv molecular thiab los txheeb xyuas cov pab pawg ua haujlwm. Cov zaj duab xis nqus ntawm HPMC ntim cov yeeb yaj kiab yog ntsuas siv Nicolet 5700 Fourier Transform infraromed spectrometer ua los ntawm thermoelectric kev lag luam. Cov zaj duab xis nyias tau siv hauv qhov kev sim no, cov qauv scanning tau qhuav nyob rau hauv lub qhov cub ziab ntawm 50 ° C rau 24 h rau infrarroscopy.
3.2.3.2 dav-lub X-ray diffraction (xrd) tsom xam: tib yam li 2.2.3.1
3.2.3.3 Kev Txiav Txim Siab ntawm Cov Khoom Siv Neeg Kho Tshuab
Lub zog tensile thiab elongation ntawm kev tawg ntawm zaj yeeb yaj kiab yog siv los ua cov kev ntsuas rau kev txiav txim rau nws cov khoom siv. Qhov elongation thaum so yog qhov sib piv ntawm qhov kev hloov chaw rau tus thawj ntev thaum zaj duab xis tawg, hauv%. Siv cov lus qhia (5943) Me me Electronic Universal Tensile Tensile Tensile Tensile Tensile cov khoom siv nrog cov khoom siv yas uas tsis muaj kev sim.
3.2.3.4 Kev txiav txim siab ntawm Optical Cov Khoom: tib yam li 2.2.3.3
3.2.3.5 Kev txiav txim siab ntawm cov dej solubility
Txiav ib lub 30 hli × 30mm zaj duab xis nrog lub tuab ntawm li 45μm, ntxiv 100ml beaker, thiab ntsuas lub sijhawm rau kev ua yeeb yaj kiab kom ploj tag [56]. Txhua qhov hnoos tau ntsuas 3 zaug thiab tus nqi nruab nrab tau coj, thiab chav tsev yog min.
3.2.4 Cov ntaub ntawv ua haujlwm
Cov ntaub ntawv sim tau ua tiav los ntawm Excel, thiab lub teeb tau kos los ntawm keeb kwm software.
3.3 Cov qhab nia thiab kev sib tham
3.3.1 Qhov cuam tshuam ntawm glycerol thiab sorbitol ntawm infrared nqus spectrum ntawm HPMC cov yeeb yaj kiab
(a) glycerol (b) sorbitol
Fig.3.1 ft-ir ntawm HPMC cov yeeb yaj kiab nyob rau hauv cov glycerol lossis sorbitolum concentrat
Infrared nqus spectroscopy (FTIR) yog ib txoj kev muaj zog rau cov pab pawg ua haujlwm muaj nyob hauv cov qauv molecular thiab los txheeb xyuas cov pab pawg ua haujlwm. Daim duab 3.1 qhia txog kev ua yeeb yaj kiab infrared ntawm HPMC nrog cov khoom sib txawv ntawm Glycerol thiab Sorbitol ntxiv. Nws tuaj yeem pom los ntawm daim duab uas cov yeeb yam ntawm HPMC zaj duab xis feem ntau yog nyob hauv ob thaj tsam: 2600 ~ 700 CLON], 348cm-1
Cov bans nqus tau yog tshwm sim los ntawm OH kev sib tw ntawm -CE ntawm -ch2, 1050cm-1 yog qhov nqus dej ntawm hydroxypropylropyl. Qhov nqus tau lub ncov ntawm cov pab pawg hydroxyl hauv qhov ncab kev xyab ntawm lub moj khaum, 945cm-1 yog lub pob zeb nqus pa ntawm -ch3 [69]. Lub Peaks nqus tau ntawm 1454cm-1, 1373CM-1, 1315CM-1 thiab 945CM-1 thiab 945cm-1 thiab 945cm-1 tau muab rau-dav hlau thiab sab-ntawm-dav hlau khoov kev qev ntawm -ch3, ntsig txog [18]. Tom qab yas, tsis muaj cov peaks nqus tshiab tau tshwm sim hauv infrared spectrum ntawm zaj duab xis, qhia tias HPMC tsis tau hloov pauv, uas yog, lub cleanizer tsis ua kom puas nws cov qauv. Nrog rau qhov ntxiv ntawm glycerol, ncab kev co ncab ntawm -oh ntawm 3418cm-1 ntawm kev nqus cov peaks uas tsis muaj zog, thiab cov peaks nqus tau tsis muaj zog, thiab cov pab pawg nqus dej tsis muaj zog, thiab cov pab pawg ua haujlwm tsis muaj zog. Nrog rau kev sib ntxiv ntawm Sorbitol mus rau HPMC zaj duab xis, the -h Ncab xyab kev co ncab ntawm 3418cm-1 tsis muaj zog, thiab qhov nqus tau peaks ntawm 1657cm-1 tsis muaj zog. Cov. Cov kev hloov pauv ntawm cov peaksacts feem ntau yog tshwm sim los ntawm kev cuam tshuam thiab muaj kev sib txuam nrog cov kev sib txuam nrog cov kab ke uas nyob ib sab -ch3 thiab -ch2. Vim tias me me, lub ntxig ntawm molecular dicalsance hinds kev tsim ntawm intrololecular hydrogen bonds, yog li lub tensile lub zog ntawm cov zaj duab xis yas txo qis [70].
3.3.2 Qhov cuam tshuam ntawm Glycerol thiab Sorbitol ntawm XRD qauv ntawm HPMC Films
(a) glycerol (b) sorbitol
Fig.3 XRD ntawm HPMC zaj duab xis nyob rau hauv cov glycerol lossis sorbitolum concentra
Dav-lub X-ray diffraction (XRD) tshuaj xyuas lub ntsej muag crystalline ntawm cov tshuaj ntawm qib molecular. Lub X-tshav teb diffracometer ntawm Arl / Xtra Hom tsim los ntawm Thermo Arl Company hauv kev txiav txim siab. Daim duab 3.2 yog QRD qauv ntawm HPMC cov yeeb yaj kiab nrog cov sib ntxiv ntawm cov glycerol thiab sorbitol. Nrog rau qhov sib ntxiv ntawm Glycerol, kev siv ntawm cov kev sib txawv ntawm lub ncov ntawm 9.5 ° thiab 20.4 ° ob qho tsis muaj zog; Nrog rau qhov sib ntxiv ntawm Sorbitol, thaum ntxiv tus nqi yog 0.15%, lub ncov siab tshaj, tab sis tag nrho cov kev sib txawv yog qhov qis dua li ntawm HPMC zaj cai uas tsis muaj Sorbitol. Nrog rau kev txuas ntxiv ntawm sorbitol, lub zog txawv ntawm 9.5 ° tsis muaj zog dua, thiab lub ncov siab sib txawv ntawm 20.4 ° tsis hloov pauv ntau. Qhov no yog vim qhov sib ntxiv ntawm cov molecules me me ntawm glycerol thiab rhuav tshem cov qauv siv lead ua ke, yog li txo cov crystallization ntawm zaj duab xis. Nws tuaj yeem pom los ntawm daim duab uas glycerol muaj qhov cuam tshuam zoo ntawm HPMC cov yeeb yaj kiab, qhia tias Glycerol thiab HPMC muaj kev sib raug zoo. Los ntawm cov txheej txheem tshuaj ntsuam ntawm cov tshuab yas, sorbitol muaj cov khoom noj qab zib zoo ib yam li cov pob zeb tsis muaj txiaj ntsig zoo ib yam li cov khoom siv tsis muaj zog, yog li nws muaj cov txiaj ntsig me me ntawm cellulose crystallization.
[48].
3.3.3 cuam tshuam ntawm glycerol thiab sorbitol ntawm cov khoom siv tshuab hpmc
Lub zog tensile thiab elongation ntawm kev tawg ntawm zaj yeeb yaj kiab yog siv los txiav txim siab los txiav txim rau nws cov khoom siv me txhua yam tuaj yeem txiav txim nws cov ntawv thov hauv qee thaj teb. Daim duab 3.3 qhia qhov hloov pauv ntawm lub zog tensile thiab elongation ntawm kev ua yeeb yaj kiab HPMC tom qab ntxiv cov yas.
Fig.3.3 Cov nyhuv ntawm glycerol lossis sorbitolumon ntawm tshuab cov khoom ntawm HPMC Films
Nws tuaj yeem pom los ntawm daim duab 3.3 (a) uas nrog ntxiv ntawm Glycerol, thaum lub tensile ua ntej poob sai sai, tom qab ntawd nce qeeb thiab tom qab ntawd txuas ntxiv kom tsawg. Kev ntev ntawm HPMC zaj duab xis ua ntej nce thiab tom qab ntawd ua rau cov khoom siv hydrophilic muaj cov nyhuv hydrothilic muaj cov nyhuv hydration [71], yog li txhim kho qhov yooj yim ntawm zaj duab xis. Nrog rau kev nce qib txuas ntxiv, kev sib txuas ntawm cov yeeb yaj kiab HPMC txo qis, thiab cov yeeb yaj kiab yog kev ntxhov siab, yog li txo lub elongation ntawm kev tawg ntawm zaj duab xis. Qhov laj thawj rau kev txo qis tensile yog: ntxiv ntawm cov me me molecules ntawm macromolecules ntawm macromolecules, thiab txo lub tensile lub zog ntawm zaj yeeb yaj kiab; Lub tensile muaj zog ntxiv, los ntawm kev pom ntawm molecular charts, thiab ua rau lub zog tensile, thiab ua rau lub zog tensile ntawm cov yeeb yaj kiab nce me ntsis; Txawm li cas los xij, thaum muaj ntau glycerol, cov molecular chains yog ib qho kev npaj ua ke, thiab tus nqi ntawm kev ua yeeb yaj kiab, ua rau muaj lub zog ntawm HPMC. Txij li thaum cov nyhuv nruj yog nyob rau cov nuj nqis ntawm tensile lub zog ntawm HPMC zaj duab xis, tus nqi ntawm glycerol ntxiv yuav tsum tsis txhob ntau dhau.
Raws li pom hauv daim duab 3.3 (B), nrog rau kev sib ntxiv ntawm Sorbitol, qhov elongation ntawm kev tawg ntawm HPMC zaj duab xis ua ntej nce thiab tom qab ntawd poob. Thaum tus nqi ntawm Sorbitol yog 0.15%, lub suab sib tham ntawm kev ua yeeb yaj kiab HPMC tau txog 45%, thiab tom qab ntawd Elongation ntawm cov zaj yeeb yaj kiab maj mam poob dua. Lub zog tensile txo qis sai, thiab tom qab ntawd hloov pauv nyob ib ncig 50MP nrog kev txuas ntxiv ntawm Sorbitol. Nws tuaj yeem pom tau tias thaum tus nqi ntawm Sorbitol ntxiv yog 0.15%, cov nyhuv yas yog qhov zoo tshaj plaws. Qhov no yog vim qhov sib ntxiv ntawm cov molecules me me ntawm sorbitol disturbs tau yooj yim rau swb, yog li ntawd elongation ntawm cov zaj duab xis nce ntxiv thiab lub zog tensile poob. Raws li tus nqi ntawm sorbitol txuas ntxiv ntxiv, qhov kev sib tw ntawm cov duab sib tw txo qis dua, vim tias cov ntsiab lus me me ntawm cov macromolecules thiab txo hauv kev ncua ntawm cov zaj duab xis.
Muab piv cov kev cuam tshuam zoo ntawm glycerol thiab sorbitol ntawm HPMC cov yeeb yaj kiab, ntxiv 0.15% Glycerol tuaj yeem nce kev sib tw ntawm cov zaj yeeb yaj kiab txog li 50%; Thaum ntxiv 0.15% Sorbitol tsuas tuaj yeem nce qhov elongation ntawm kev tawg ntawm zaj duab xis tus nqi nce txog 45%. Lub zog tensile poob qis, thiab qhov qis dua yog me dua thaum Glycerol tau ntxiv. Nws tuaj yeem pom tau tias cov txiaj ntsig zoo ntawm Glycerol ntawm HPMC zaj duab xis yog qhov zoo dua li ntawm Sorbitol.
3.3.4 cuam tshuam ntawm glycerol thiab sorbitol ntawm lub zog kho qhov muag ntawm HPMC cov yeeb yaj kiab
(a) glycerol (b) sorbitol
Fig.3.4 Cov nyhuv ntawm glycerol lossis sorbitolumon cov khoom kho kho kho kho ntawm HPMC Films
Teeb pauv kev hloov pauv thiab kub kub yog qhov tseem ceeb ntawm cov pob tshab ntawm cov khoom ntim ntim. Qhov pom thiab pom tseeb ntawm cov khoom ntim ntim tsuas yog nyob ntawm qhov kev hloov pauv ntawm cov khoom ntim ntim khoom. Raws li muaj nyob hauv Daim Duab 3.4, ntxiv rau ntawm glycerol thiab sorbitol ob qho tib si cuam tshuam cov khoom siv kho qhov muag ntawm HPMC cov yeeb yaj kiab, tshwj xeeb yog cov nnyob. Daim duab 3.4 (A) yog daim duab qhia txog cov nyhuv ntawm glycerol ntxiv rau ntawm cov khoom kho kho ntawm HPMC ntawm HPMC zaj duab xis. Nrog rau qhov sib txuas ntxiv ntawm HPMC cov yeeb yaj kiab ua ntej nce thiab tom qab ntawd poob qis yam siab tshaj plaws nyob ib puag ncig 0.25%; Nzle Haze tau nce sai thiab maj mam. Nws tuaj yeem pom los ntawm kev txheeb xyuas saum toj no uas thaum txuas ntxiv ntawm Glycerol yog 0.25%, cov khoom siv kho tshiab tau zoo dua, yog li ntawd ntxiv ntawm glycerol yuav tsum tsis pub tshaj 0.25%. Daim duab 3.4 (b) yog daim duab qhia txog cov txiaj ntsig ntawm Sorbitol ntxiv rau ntawm cov khoom kho kho ntawm HPMC ntawm HPMC zaj duab xis. Nws tuaj yeem pom los ntawm daim duab uas nrog kev sib ntxiv ntawm Sorbitol, qhov kev ua yeeb yaj kiab Haze ntawm HPMC cov yeeb yaj kiab nce ntxiv thiab tom qab kev hloov pauv nce ua ntej thiab tom qab nce. Kev txo qis, thiab kev hloov chaw kaj kev thiab taws teeb tshwm sim tib lub sij hawm thaum tus nqi ntawm sorbitol yog 0.45%. Nws tuaj yeem pom tau tias thaum tus nqi ntawm Sorbitol ntxiv yog nyob ntawm 0.35 thiab 0.45%, nws cov khoom kho tshiab tau zoo dua. Muab piv rau glycerol thiab sorbitol ntawm cov khoom siv kho qhov muag ntawm HPMC cov yeeb yaj kiab, nws tuaj yeem pom tias Sorbitol muaj cov txiaj ntsig me me ntawm cov khoom kho tshiab ntawm cov yeeb yaj kiab.
Feem ntau hais lus, cov ntaub ntawv kev hloov pauv siab yuav muaj qis dua taws kub siab, thiab hloov pauv vicea, tab sis qhov no tsis yog ib txwm muaj. Qee cov ntaub ntawv muaj cov teeb meem loj dua tab sis kuj tseem ceeb kub kub muaj nuj nqis, xws li cov yeeb yaj kiab nyias zoo li iav khov [73]. Zaj duab xis npaj nyob rau hauv qhov kev sim no tuaj yeem xaiv cov yas yas yas thiab ntxiv cov nqi raws li qhov xav tau.
3.3.5 Qhov cuam tshuam ntawm glycerol thiab sorbitol ntawm cov dej solubility ntawm HPMC Films
(a) glycerol (b) sorbitol
Fig.3.5 Cov nyhuv ntawm glycerol lossis sorbitolumon dej solubility ntawm HPMC Films
Daim duab 3.5 qhia cov nyhuv ntawm glycerol thiab sorbitol ntawm cov dej solubility ntawm HPMC zaj duab xis. Nws tuaj yeem pom los ntawm daim duab uas nrog cov kev nce ntxiv ntawm cov yas ua kom tiav, thiab cov dej ua kua rau ntawm cov dej solubility ntawm HPMC zaj duab xis tshaj sorbitol. Qhov laj thawj yog vim li cas hydroxypropyl methylcelulose muaj cov dej solubility zoo yog vim tias muaj cov pab pawg hydroxyl hauv nws cov molecule. Los ntawm kev tsom xam ntawm infrared spectrum, nws tuaj yeem pom tau tias nrog cov pab pawg hydroxyl, yog li cov dej solubility ntawm Hydubility ntawm Hydubility ntawm Hydubility ntawm Hydubility ntawm Hydubility ntawm HOLMC zaj duab xis txo qis.
3.4 Cov ntu ntawm tshooj no
Los ntawm cov yeeb yaj kiab saum toj no ntawm HPMC cov yeeb yaj kiab, nws tuaj yeem pom tau tias cov yas gascerol thiab nce mus elongation ntawm cov yeeb yaj kiab. Thaum ntxiv ntawm Glycerol yog 0.15%, cov duab ua yeeb yam ntawm HPMC cov yeeb yaj kiab yog qhov zoo, lub zog, thiab kev mus elongation yog li 50%; Thaum ntxiv ntawm glycerol yog 0.25%, lub zog kho qhov muag tau zoo dua. Thaum cov ntsiab lus ntawm Sorbitol yog 0.15%, lub zog tensile ntawm HPMC zaj duab xis yog kwv yees li 55mpa, thiab elongation thaum tawg nce txog 45%. Thaum cov ntsiab lus ntawm Sorbitol yog 0.45%, lub zog kho qhov muag ntawm zaj duab xis zoo dua. Ob lub tshuab pa roj hmab txo cov dej solubility ntawm HPMC cov yeeb yaj kiab, thaum Sorbitol tsis tshua muaj cuam tshuam rau cov dej solubility ntawm HPMC zaj duab xis. Qhov kev sib piv ntawm cov teebmeem ntawm ob lub tshuab yas rau ntawm cov khoom ntawm HPMC cov yeeb yaj kiab qhia tau hais tias cov yeeb yaj kiab HPMC ntawm HPMC cov yeeb yaj kiab zoo dua li ntawm Sorbitol.
Tshooj 4 Teeb meem ntawm cov neeg sawv cev ntawm HPMC dej-soluble ntim cov yeeb yaj kiab
4.1 Kev Taw Qhia
HydroxyPropyyl methylulose muaj ntau pawg hydroxyl thiab hydroxyprropoxy pawg, yog li nws muaj cov dej solubility zoo. Daim ntawv no siv nws cov dej solubility zoo los npaj cov dab neeg tshiab thiab ib puag ncig cov dej zoo li cov dej-soluble ntim zaj duab xis. Nyob ntawm daim ntawv thov ntawm dej-solubble zaj duab xis, nrawm dua ntawm cov ntawv tso dej-solub-solom, tab sis qee zaum ncua kev sib cais yog tseem yuav muaj kev sib cais yog tseem xav tau [21].
Yog li ntawd, nyob rau hauv tshooj no, glutaraldehyde yog siv los ua tus neeg sawv cev sib txuas rau cov dej-solubility, thiab nws lub sijhawm ua haujlwm ntawm cov yeeb yaj kiab thiab ncua lub sijhawm ua haujlwm. Qhov cuam tshuam ntawm txawv glutaraldehyde ntim ntxiv rau ntawm cov dej solubility, cov khoom siv tshuab ntawm hydroxypropylulose zaj duab xis tau kawm.
4.2 Kev sim
4.2.1 sim cov ntaub ntawv thiab cov twj siv
Cov lus 4.1 sim cov ntaub ntawv thiab cov lus qhia tshwj xeeb
4.2.2 Kev Npaj Ua Quav
1) Kev hnyav: hnyav me ntsis ntawm hydroxypropyl methylculose (5%) nrog hluav taws xob sib npaug;
2) Kev Ua Kom Xaus: Lub cev hnyav HydroxyPropyl me me ntxiv rau cov dej uas muaj dealordehyde, thiab tom qab ntawd, 0.44%, 0.44%, 0.29% Glutaraldehyde ntxiv nyiaj tau;
3) zaj duab xis ua: txhaj rau zaj duab xis ua cov kua rau hauv cov iav petri, muab tso rau hauv cov zaj duab xis, muab tso rau hauv cov zaj duab xis, thiab muab tso rau hauv lub thawv qhuav rau thaub qab.
4.2.3 Ceeb tsheej thiab kev sim ua haujlwm
4.2.3.1 Infrared nqus spectroscopy (ft-ir) tsom xam
Cov yeeb yaj kiab Infrared ntawm HPMC cov yeeb yaj kiab tau txiav txim siab siv cov Nicolet 5700 Filier infrared spectrometer ua rau los ntawm Asmeskas boiloelectric tuam txhab kaw lub spectrum.
4.2.3.2 The-Lub Xoo Hluav Taws Xob Ua Ntej Xiav Riam (XRD)
Dav xoo hluav taws xob xoo rhawv diffraction (XRD) yog kev soj ntsuam ntawm lub xeev crystallization ntawm cov khoom ntawm qib molecular. Hauv daim ntawv no, lub xeev crystallization tau txiav txim siab siv ARL / XTRA X-RH duab Diffractracter ua los ntawm Thermo Arl ntawm Switzerland. Kev ntsuas tej yam kev ntsuas: xoo hluav taws xob cov khoom siv npib tsib xee npib tsib xee (40 kV, 40 ma). Tshawb cov kaum sab xis ntawm 0 ° txog 80 ° (2θ). Tshawb Fawb Txog 6 ° / Min.
4.2.3.3 txiav txim siab ntawm cov dej solubility: tib yam li 2.2.3.4
4.2.3.4 Kev Txiav Txim Siab ntawm Cov Khoom Siv Neeg Kho Tshuab
Siv cov thev naus laus zis (5943) Me Me Electronic Universal Tensile Tensile Tensile Tensile cov cuab yeej ntawm cov khoom siv yas, raws li cov qauv sib dhos ntawm cov khoom siv yas yam tsis muaj kev sim.
4.2.3.5 Kev Txiav Txim Siab ntawm Optical Cov Khoom Siv
Siv cov phiaj xwm kev sib txuas ua ke Haze, xaiv cov qauv los kuaj nrog ib qho kev sib txuas lus huv thiab kev hloov pauv thiab ntsuas cov yeeb yaj kiab ntawm chav sov (25 ° C thiab 50% Rh).
4.2.4 Cov ntaub ntawv ua haujlwm
Cov ntaub ntawv sim tau ua tiav los ntawm kev sib tw thiab graphed los ntawm keeb kwm software.
4.3 Cov Lus Qhia thiab Kev Sib Tham
4.3.1 Infrared nqus spectra ntawm glutaraldehyde-crosslinked hpmc cov yeeb yaj kiab
Fig.4.1 ft-ir ntawm HPMC zaj duab xis nyob rau hauv cov ntsiab lus glutaraldeHyde cov ntsiab lus
Infrared nqus spectroscopy yog cov txhais tau tias muaj txiaj ntsig zoo rau cov pab pawg ua haujlwm muaj nyob hauv cov qauv molecular thiab los txheeb xyuas cov pab pawg ua haujlwm. Txhawm rau kom nkag siab ntxiv cov kev hloov pauv ntawm hydroxypropylulose tom qab kev ntsuam xyuas tau ua rau HPMC cov yeeb yaj kiab ua ntej thiab tom qab hloov kho. Daim duab 4.1 qhia txog kev ua yeeb yaj kiab infrared ntawm hpmc nrog cov sib txawv ntawm glutaraldehyde, thiab deformation ntawm HPMC Films
Lub vibreatorathation peaks ntawm -oh yog ze 3418cm-1 thiab 1657cm-1. Muab piv rau cov pab pawg Hydroxy, nws tuaj yeem pom tau tias muaj zog ntawm Hydroxyl Molecule tau txo qis, uas tau tshwm sim los ntawm kev sib txuas ntawm cov pab cuam tshuam hydroxyl ntawm Hydroxyl pawg ntawm Hydrothyde pab pawg ntawm Glutaraldehyde [74]. Ib qho ntxiv, nws tau pom tias qhov sib ntxiv ntawm glutaraldehyde tsis hloov txoj hauj lwm ntawm txhua tus yam ntxwv ntawm glutaraldehyde tsis ua kom puas pab pawg HPMC nws tus kheej.
4.3.2 xrd qauv ntawm GlutaraldeHyde-hla kev kub HPMC cov yeeb yaj kiab
Los ntawm kev ua yeeb yaj kiab diffraction rau ntawm cov khoom siv thiab kev txheeb xyuas nws cov qauv sib txawv, nws yog qhov kev tshawb nrhiav kom tau txais cov ntaub ntawv lossis morphology ntawm atoms lossis lwg hauv cov khoom. Daim duab 4.2 Qhia tus qauv Xrd ntawm HPMC zaj duab xis nrog txawv glutaraldehyde ntxiv. Nrog rau kev nce ntawm glutaraldehyde ntxiv, kev siv ntawm cov kev sib txawv ntawm HPMC nyob ib ncig ntawm 9.4 ° tsis muaj zog, vim tias aldehydes ntawm glutaraldehyde tsis muaj zog. Cov kev sib tw hla kev sib txawv tshwm sim tshwm sim ntawm cov pab pawg hydroxyl thiab yog li txo qhov peev xwm moleculle [75], yog li txo qhov peev xwm ntawm hpmc.
Fig.4.2 xrd ntawm HPMC cov yeeb yaj kiab nyob rau hauv ntau glutaraldeDaldeHyde cov ntsiab lus
4.3.3 Cov nyhuv ntawm glutaraldehyde ntawm dej solubility ntawm HPMC Films
Fig.4.3 Cov nyhuv ntawm glutaraldehyde rau dej solubility ntawm HPMC Films
Los ntawm Daim Duab 4.3 Cov nyhuv ntawm cov sib txawv glutaraldehyde ntxiv rau cov dej solubility, nws tuaj yeem pom tau tias kev nce qib HPMC, nws tuaj yeem pom tau tias cov yeeb yaj kiab HPMC ntawm HPMC zaj duab xis yog ntev. Cov kev sib txuas hla kev sib txuas nrog cov pab pawg aldehyde, yog li ua rau muaj kev sib tw ntawm Hydroxyl thiab ua rau lub sijhawm ua yeeb yaj kiab HOLMCC thiab txo cov dej solubility ntawm HPMC zaj duab xis.
4.3.4 nyhuv ntawm glutaraldehyde ntawm cov khoom siv me ntsis ntawm HPMC cov yeeb yaj kiab
Fig.4.4 Cov nyhuv ntawm glutaraldehyde ntawm tensile lub zog thiab tawg elongation ntawm HPMC cov yeeb yaj kiab
Txhawm rau tshawb xyuas cov nyhuv ntawm glutaraldehyde cov ntsiab lus ntawm HPMC cov yeeb yaj kiab, lub zog tensile thiab elongation ntawm kev tawg cov yeeb yaj kiab tau sim. Piv txwv li, 4.4 yog daim duab ntawm cov txiaj ntsig ntawm glutaraldehyde ntxiv rau ntawm lub zog tensile thiab elongation ntawm kev tawg ntawm zaj duab xis. Nrog rau kev nce ntawm glutaraldehyde ntxiv, lub zog tensile thiab elongation ntawm kev tawg HPMC zaj duab xis nce ua ntej thiab tom qab nqis. tus qauv ntawm. Txij li thaum hla kev sib txuas ntawm Glutaraldehyde thiab cov pab pawg ntawm HellCC, tom qab ntxiv cov khoom sib tw HellCC, tom qab ntxiv cov khoom siv tshuab, nce cov cuab yeej siv ntawm HPMC Films. Nrog rau kev sib ntxiv txuas ntxiv ntawm glutaraldehyde, cov kev sib tw molecules, thiab cov lus qhia molecules yog tsis yooj yim rau hauv HPMC nyias cov yeeb yaj kiab poob macroscopically [76]]. Los ntawm Daim Duab 4.4, cov nyhuv ntawm glutaraldehyde ntawm cov neeg ua yeeb yam ntawm HBMC zaj yeeb yaj kiab qhia tau zoo dua, thiab cov kws ua yeeb yaj kiab ntawm HPMC cov yeeb yaj kiab zoo dua.
4.3.5 Cov nyhuv ntawm glutaraldehyde ntawm lub zog kho qhov muag ntawm HPMC cov yeeb yaj kiab
Teeb pauv kev hloov pauv thiab kub kub yog ob qho tseem ceeb heev kho qhov muag ua tsis tau zoo ntawm kev ntim cov yeeb yaj kiab. Qhov kev hloov pauv ntau dua, qhov zoo dua ntawm cov yeeb yaj kiab; Cov nqaij npau suav, tseem muaj qhov tseeb, qhia txog qhov tseeb ntawm cov yeeb yaj kiab, thiab qhov loj dua li, qhov tsis zoo rau cov yeeb yaj kiab. Daim duab 4.5 yog cov nkhaus nkhaus ntawm kev ntxiv ntawm glutaraldehyde ntawm qhov kho qhov muag ntawm HPMC zaj duab xis. Nws tuaj yeem pom los ntawm daim duab uas nrog kev nce ntxiv ntawm glutaraldehyde, hloov pauv hloov ua ntej qeeb, tom qab ntawd nce qeeb thiab tom qab ntawd txo qis; Nze nws ua ntej txo thiab tom qab ntawd nce. Thaum qhov sib txuas ntxiv ntawm Glutaraldehyde yog 0.25%, cov kev sib txuas lus ntawm HPMC zaj duab xis tau mus txog tus nqi siab tshaj plaws ntawm 93%, thiab covze taws tau txog tus nqi yam tsawg kawg nkaus ntawm 13%. Nyob rau lub sijhawm no, kev ua tau kho qhov muag tau zoo dua. Qhov laj thawj rau qhov nce hauv kho qhov muag yog qhov sib txuas ntawm cov duab glutardehydulose, thiab cov khoom sib xyaw, uas nce cov yeeb yaj kiab ntawm HPMC ntawm HPMC zaj duab xis [77-79]. Thaum tus neeg sawv cev hla kev sib txuas yog ntau dhau, cov chaw hla kev hla ntawm cov qauv molecules ntawm lub system yog qhov yooj yim tshwm sim. Yog li ntawd, lub zog kho qhov muag ntawm HPMC cov yeeb yaj kiab yog txo qis [80].
Fig.4.5 Cov nyhuv ntawm glutaraldehyde ntawm Optical cov cuab yeej ntawm HPMC Films
4.4 ntu ntawm tshooj no
Los ntawm kev tsom xam saum toj no, cov lus xaus hauv qab no yog kos:
1) Cov lus qhia zaj yeeb yaj kiab Glutaraldehyde-Bosslinked HPMC qhia tau hais tias Glutaraldehyde thiab HPMC zaj duab xis yauv hla kev sib txuas sib txuas.
2) Nws yog qhov tsim nyog dua ntxiv glutaraldehyde nyob rau hauv ntau ntawm 0.25% rau 0.44%. Thaum tus nqi ntxiv ntawm glutaraldehyde yog 0.25%, cov khoom siv kho tshuab thiab kho qhov muag ntawm HPMC zoo dua; Tom qab kev sib hla hla, cov dej solubility ntawm HPMC zaj duab xis yog ntev thiab cov dej solubility txo. Thaum tus nqi ntxiv ntawm Glutaraldehyde yog 0.44%, cov dej solubility lub sijhawm ncav cuag txog 135min.
Tshooj 5 ntuj antioxidant HPMC Dej Soluble Ntim Zaj Duab Xis
5.1 Kev qhia lus
Txhawm rau nthuav tawm cov ntawv thov ntawm hydroxypropyl methylcellulose zaj duab xis nyob rau hauv cov zaub mov ntim, thiab siv kev daws teeb meem kev ua yeeb yaj kiab ua yeeb yaj kiab, thiab siv cov ntoo ntsuab Antioxidant HPMC Dej-soluble ntim zaj duab xis, kawm cov khoom antioxidant thiab kho cov khoom siv ntawm zaj duab xis, thiab muab ib lub hauv paus rau nws cov ntawv thov hauv cov khoom noj ntim khoom noj.
5.2 Kev sim sim
5.2.1 Kev sim cov khoom siv thiab cov cuab yeej sim
Tab.5.1 Kev sim cov ntaub ntawv thiab cov lus qhia tshwj xeeb
Tab.5.2 Kev sim ua cov apparatus thiab specifications
5.2.2 Kev Npaj Ua Quav
Npaj hydroxypropy kas methylcellulose dej-soluble ntim cov yeeb yaj kiab nrog kev daws teeb meem me me, thiab tom qab ntawd 0.03%, 0.07%, 0.09%) ntawm Xyoob nplooj antioxidants rau lub cellulose zaj duab xis-forming tov, thiab txuas ntxiv mus do
Yuav kom tag nrho cov kev sib xyaw, cia sawv ntsug ntawm chav sov rau 3-5 feeb) los npaj HPMC cov kev sib txawv ntawm cov kab sib txawv ntawm xyoob ntoo antioxidants. Qhuav nws nyob rau hauv lub qhov cub kom qhuav qhuav, thiab muab tso rau hauv qhov cub ziab rau kev siv tom qab siv tom qab peeling tawm zaj duab xis. Qhov npaj hydroxypropyl methylpcellulose dej-doluble ntim zaj duab xis ntxiv nrog xyoob nplooj antioxidant yog hu ua Aob / HPMC zaj duab xis rau luv.
5.2.3 Ceeb toom thiab kev sim ua haujlwm
5.2.3.1 Infrared nqus spectroscopy (ft-ir) tsom xam
Lub infrared nqus tau spectra ntawm HPMC cov yeeb yaj kiab tau ntsuas hauv hom ATR hom uas siv cov Nicolet 5700 Plaub Hloov Infrated Spectrometer ua rau los ntawm Thermoelectric kev lag luam.
5.2.3.2 dav-lub kaum ntse ntse x-ray diffraction (XRD) ntsuas: tib yam li 2.2.3.1
5.2.3.3 Kev txiav txim siab ntawm Antioxidant Khoom
Txhawm rau ntsuas cov tshuaj tiv thaiv kab mob antioxidant ntawm npaj HPMC cov yeeb yaj kiab thiab Aob / HPMC cov yeeb yaj kiab, yog li ntawd kev ntsuas cov oxidation tsis kam ntawm cov yeeb yaj kiab.
Kev npaj dpph kev daws teeb meem: nyob rau hauv shadve 2 mg ntawm dpph hauv ethanol cov kuab tshuaj, thiab sonicate rau 5 feeb los ua kom cov kev daws teeb meem. Khaws rau hauv tub yees (4 ° C) rau kev siv tom qab.
Xa mus rau cov txheej txheem sim ntawm zhong yuanheng [81], nrog rau kev ntsuas me me, muab 2 ml yog A0. Kev ntsuas ntawm tus nqi: ntxiv 2 ml ntawm DPPH kev daws teeb meem, txuas ntxiv 1 ml Dpph Free radical txaus luag cov qauv kev xam hais txog cov qauv nram qab no,
Hauv cov qauv: A yog qhov nqus ntawm cov qauv; A0 yog qhov chaw tswj dawb
5.2.3.4 Kev txiav txim siab ntawm cov tshuab khoom siv khoom: tib yam li 2.2.3.2
5.2.3.5 Kev Txiav Txim Siab ntawm Optical Cov Khoom Siv
Qhov ntsuas kho tau yog qhov ntsuas tseem ceeb ntawm cov pob tshab ntim cov khoom siv ntim khoom, feem ntau yog suav nrog kev hloov pauv thiab kub ntawm zaj duab xis. Kev hloov pauv thiab kub ntawm cov yeeb yaj kiab tau ntsuas siv cov kev hloov pauv Haze Taleer. Lub teeb rau kev hloov pauv thiab kub ntawm cov yeeb yaj kiab tau ntsuas ntawm chav tsev kub (25 ° C thiab 50% Rh) ntawm cov qauv ntxuav nrog cov chaw huv thiab tsis muaj kev muaj mob.
5.2.3.6 Kev Txiav Txim Siab ntawm cov dej solubility
Txiav ib lub 30mm × 30mm zaj duab xis nrog lub tuab ntawm kwv yees li 45μm, muab zaj duab xis nyob rau hauv nruab nrab ntawm lub sij hawm dej rau saum npoo av, thiab ntsuas lub sijhawm rau zaj duab xis kom ploj mus tag. Yog tias zaj duab xis lo rau phab ntsa ntawm lub beaker, nws yuav tsum tau ntsuas dua, thiab qhov tshwm sim yog coj los ua qhov nruab nrab ntawm 3 zaug, chav tsev yog min.
5.2.4 Cov ntaub ntawv ua haujlwm
Cov ntaub ntawv sim tau ua tiav los ntawm kev sib tw thiab graphed los ntawm keeb kwm software.
5.3 Cov Ntsiab Lus thiab Kev Ntsuam Xyuas
5.3.1 FT-IRACH
Fig5.1 Ftir ntawm HPMC thiab Aob / HPMC Films
Hauv cov lwg organic, cov atoms uas ua rau cov neeg siv tshuaj lom neeg lossis pab pawg ua haujlwm yog nyob rau hauv lub xeev ntawm kev co tas li. Thaum cov organic molecules yog irradiated ntawm infrared teeb, yog li cov ntaub ntawv hais txog cov pab pawg neeg lossis cov pab pawg ua haujlwm hauv cov molecule tuaj yeem tau txais. Daim duab 5.1 qhia txog FTIR Spectra ntawm HPMC zaj duab xis thiab Aob / HPMC zaj duab xis. Los ntawm Daim Duab 5, nws tuaj yeem pom tias cov xeeb ceem ntawm cov pob txha pob txha taub hau kev co ntawm hydroxypropylulose yog feem ntau sececturescellulose feem ntau yog concentraccellulose feem ntau yog concentrated nyob rau hauv 2600100 CM-1 thiab 750 ~ 1700 CM-1. Qhov muaj zog kev co nyob rau hauv 950-1250 CM-1 thaj av yog tsuas yog cov xeeb ceem ntawm cov pob txha pob txha ncab kev co. Pab Pawg HPMC ze 348 CM-1 yog tshwm sim los ntawm qhov kev ncab ntawm cov pab pawg hydroxyprropoxy ntawm lub moj khaum Lub Peaks nqus tau ntawm 1454cm-1, 1373CM-1, 1315cm-1 thiab 945cm-1 tau tshaj tawm rau Asymmetric, kev tawm tsam sab nraud thiab sab nraud ntawm-dav hlau khoov reeping deeping rau -ch3 [83]. HPMC tau hloov kho nrog aob. Nrog qhov sib ntxiv ntawm Aob, txoj hauj lwm ntawm txhua tus cwj pwm ntawm Aob / HPMC tsis tau hloov, qhia tias qhov sib ntxiv ntawm HPMC nws tus kheej. Qhov kev ua kom ncab cov kev sib tw ntawm txoj kev nqus cov qhab-nees ntawm lub pob zeb Aob / HPM yog qhov tsis muaj zog, thiab cov kev hloov pauv ntawm Methyl thiab Methylene Bands vim yog cov hydrogen bond induction. 12], Nws tuaj yeem pom tias qhov kev sib ntxiv ntawm AOB muaj qhov cuam tshuam rau cov kev sib txuam hydrogen hydrogen bonds.
5.3.2 xrd tsom kwm
Fig.5.2 xrd ntawm HPMC thiab Aob /
Fig.5.2 xrd ntawm HPMC thiab Aob / HPMC Films
Lub xeev crystalline ntawm cov yeeb yaj kiab tau raug tshuaj xyuas los ntawm dav-kaum sab xis X-ray diffraction. Daim duab 5.2 Qhia tus qauv Xrd ntawm HPMC zaj yeeb yaj kiab thiab AAOB / HPMC Films. Nws tuaj yeem pom los ntawm daim duab uas HPMC zaj duab xis tau 2 qhov kev sib tw sib txawv (9.5 °, 20.4 °). Nrog rau kev sib ntxiv ntawm aob, cov diffraction peaks nyob ib ncig ntawm 9.4 ° yog tsis muaj zog, qhia tias cov lwg me me ntawm Aob / HPMC zaj duab xis tau npaj rau hauv kev txiav txim. Lub peev xwm poob qis, qhia tau tias qhov sib ntxiv ntawm lub cev ntawm hydrotylropeny moleculopulose moleculopulose moleculopulose moleculopulose moleculopulose moleculopulose moleculopulose moleculoplcellen
5.3.3 antioxidant thaj chaw
Txhawm rau tshawb cov nyhuv ntawm lub pob sib txawv ntxiv ntawm oxidation tiv thaiv ntawm aob / hpmc zaj duab xis, 0.05%, 0.09%) tau tshawb nrhiav, feem ntau. Cov nyhuv ntawm tus nqi txav ntawm lub hauv paus, cov txiaj ntsig tau pom hauv daim duab 5.3.
Fig.5.3 Cov txiaj ntsig ntawm HPMC cov yeeb yaj kiab hauv qab AAB cov ntsiab lus ntawm DPPPHition
Nws tuaj yeem pom los ntawm daim duab 5.3 Qhov ntxiv ntawm Aob Antioxidant Tshaj Plaws ntawm cov yeeb yaj kiab ntawm DPPhuns, thiab kev ua yeeb yaj kiab ntawm DPPhunks ua ntej nce ntxiv tom qab maj mam poob qis. Thaum tus nqi ntxiv ntawm Aob yog 0.03%, cov yeeb yaj kiab Aob / HPMC muaj qhov ua tau zoo tshaj plaws ntawm DPPK / HPMC zaj duab xis muaj qhov kev ua yeeb yaj kiab oxidation zoo tshaj plaws thaum lub sijhawm no; Thaum lub AB lub ntsiab lus yog 0.05% thiab 0.07%, DPPH%, DPMC zaj duab xis tau siab tshaj qhov ntawm 0.03% pab pawg; Qhov no tuaj yeem yog vim muaj antioxidants ntxiv rau lub AGGlomeration thiab tsis sib xws ntawm cov nyhuv antioxidant ntawm Aob / HPMC zaj duab xis. Nws tuaj yeem pom tau tias Aob / HPMC zaj duab xis npaj hauv kev sim muaj kev tawm tsam oxidation zoo. Thaum tus nqi ntxiv yog 0.03%, anti-oxidation kev ua haujlwm ntawm Aob / HPMC zaj duab xis yog qhov muaj zog tshaj.
5.3.4 DEJ Solubility
Los ntawm Daim Duab 5.4, cov nyhuv ntawm xyoob nplooj antioxidants ntawm hydroxypropulose zaj duab xis, nws tuaj yeem pom tias cov dej sib txawv ntawm cov dej solubility ntawm HPMC zaj duab xis. Tom qab ntxiv aob, nrog kev nce ntawm aob, lub sijhawm dej-solub tau luv dua, kev ua yeeb yaj kiab ntawm Aob / HPMC zaj duab xis tau zoo dua. Qhov ntawd yog hais, qhov sib ntxiv ntawm lub aob txhim kho lub aob / hpmc dej solubility ntawm zaj duab xis. Los ntawm XRD dhau los kev tsom xam, nws tuaj yeem pom tau hais tias tom qab ntxiv aobules ntawm Aob / HPMC zaj duab xis tau txhim kho rau qee yam. Dej solubility ntawm zaj duab xis.
Fig.5.4 Cov nyhuv ntawm AOB ntawm Dej Soluble HPMC Films
5.3.5 Cov Khoom Siv Neeg Kho Tshuab
Fig.5.5 Cov nyhuv ntawm aob ntawm tensile lub zog thiab tawg elongation ntawm HPMC cov yeeb yaj kiab
Daim ntawv thov ntawm cov khoom ua yeeb yaj kiab nyias nyias muaj ntau dua thiab muaj ntau yam ntxiv, thiab nws cov khoom siv neeg muaj txiaj ntsig ntawm cov kev pabcuam kev pabcuam, uas tau dhau los ua cov kev tshawb fawb tshawb fawb. Daim duab 5.5 qhia lub zog tensile thiab elongation ntawm tawg curves ntawm Aob / HPMC zaj duab xis. Nws tuaj yeem pom los ntawm daim duab uas txawv Aob ntxiv muaj cov teebmeem tseem ceeb ntawm cov khoom siv ntawm cov yeeb yaj kiab. Tom qab ntxiv aob, nrog qhov nce ntawm aob ntxiv, AOB / HPMC. Lub zog tensile ntawm zaj yeeb yaj kiab qhia ib tug downward txawv, thaum lub elongation thaum tawg pom tias muaj kev nce qib ua ntej thiab tom qab ntawd tsawg dua. Thaum lub AB lub ntsiab lus yog 0.01%, lub elongation ntawm kev tawg ntawm zaj duab xis tau mus txog tus nqi siab tshaj plaws ntawm li 45%. Cov nyhuv ntawm AOB ntawm cov khoom siv tshuab hluav taws xob ntawm HPMC zaj duab xis yog pom tseeb. Los ntawm XRD tsom xam, nws tuaj yeem pom tias qhov sib ntxiv ntawm antioxidant AoB txo lub crystallinity ntawm Aobstallinity ntawm Aobstallinity ntawm lub tensile lub zog ntawm Aob / HPMC zaj duab xis. Elongation thaum tawg ua ntej nce thiab tom qab ntawd txo qis, vim tias AOB muaj cov dej solubility thiab sib xyaw ua ke, thiab yog ib qho khoom siv roj av me me. Thaum lub sij hawm cov txheej txheem ntawm compatibility nrog HPMC, kev sib cuam tshuam ntawm cov lwg me me tsis muaj zog thiab cov yeeb yaj kiab yog softened. Tus qauv nruj ua rau Aob / hpmc zaj duab xis mos thiab elongation ntawm kev tawg ntawm zaj duab xis nce; Raws li tus aob tseem nce ntxiv, qhov kev sib tw ntawm Aob / HPMC ua rau Macromolecules, thiab tsis muaj kev sib tw ntawm lub pob zeb Aob / HPMC txo qis.
5.3.6 kho qhov muag
Fig.5.6 Cov nyhuv ntawm Aob ntawm cov khoom ntiag tug ntawm HPMC zaj yeeb yaj kiab
Daim duab 5.6 yog daim duab qhia txog kev hloov pauv ntawm kev hloov pauv thiab taws kub ntawm Aob / HPMC zaj duab xis. Nws tuaj yeem pom los ntawm daim duab uas nrog kev nce ntawm tus nqi ntxiv, kev hloov pauv ntawm Aob / HPMC zaj duab xis txo qis thiab cov taws nce. Thaum AOB cov ntsiab lus tsis pub dhau 0.05%, cov kev hloov pauv ntawm lub teeb transmitt thiab kub ntawm Aob / HPMC zaj duab xis tau qeeb; Thaum lub AB lub ntsiab lus tshaj 0.05%, cov kev hloov pauv ntawm lub teeb kev hloov pauv thiab kub kub tau nrawm. Yog li ntawd, tus nqi ntawm aob ntxiv yuav tsum tsis pub tshaj 0.05%.
5.4 Tshooj ntawm tshooj no
Noj xyoob ntoo antioxidant (aob) raws li ntuj antioxidant thiab hydroxypropal ntim zaj duab xis tau npaj los ntawm kev daws kev sib xyaw thiab cov qauv kev ua yeeb yaj kiab. Aob / hpmc dej-soluble ntim zaj duab xis npaj nyob rau hauv qhov kev sim no muaj cov khoom muaj nuj nqis ntawm kev tawm tsam oxidation. Lub Aob / HPMC zaj duab xis nrog 0.03% AOB muaj tus nqi txaus siab txog li 89% rau DPPHing kev ua tau zoo yog qhov zoo tshaj plaws, uas yog qhov zoo dua li tias tsis muaj aob. HPMC zaj duab xis ntawm 61% txhim kho. Cov dej solubility yog tseem txhim kho, thiab cov khoom siv neeg kho mob thiab kho qhov muag tau tsawg dua. Cov oxidation txhim kho tiv thaiv Aob / HPMC zaj duab xis tau nthuav nws cov ntawv thov hauv ntim zaub mov.
Tshooj Lus VI TAG
1) Nrog rau qhov nce ntawm HPMC-ua cov tshuaj tov, cov khoom siv me me ntawm cov yeeb yaj kiab ua ntej nce thiab tom qab ntawd poob qis. Thaum HPMC cov yeeb yaj kiab-ua cov tshuaj muaj zog yog 5%, cov duab ua yeeb yam ntawm HPMC zaj duab xis tau zoo dua, thiab lub zog tensile yog 116mpa. Elongation thaum so yog li 31%; Lub zog kho qhov muag thiab cov dej solubility txo qis.
2) Nrog rau kev nce ntawm zaj duab xis tsim kev daws qhov kub, cov neeg kho tshuab ntawm cov yeeb yaj kiab ua ntej nce thiab tom qab ntawd kho qhov muag zoo dua qub, thiab cov dej solubility txo. Thaum cov yeeb yaj kiab-tsim kub yog 50 ° C, tag nrho cov kev ua tau zoo dua yog li ntawm 906MPA, yog li cov duab transcotion yog li 55min, yog li cov yeeb yaj kiab-tsim kub yog qhov haum 50 ° C.
3) Siv cov hnab looj tes los txhim kho cov yeeb yaj kiab HPMC, nrog kev sib ntxiv ntawm HPMC cov yeeb yaj kiab tau nce ntau, thaum lub zog tensile poob qis. Thaum tus nqi ntawm glycerol ntxiv yog nyob nruab nrab ntawm 0.15%, lub elongation ntawm kev tawg ntawm HPMC zaj duab xis tau kwv yees li 50%, thiab lub zog tensile yog li 60mpa.
4) Nrog rau qhov sib ntxiv ntawm Sorbitol, lub elongation ntawm kev tawg ntawm zaj duab xis nce ua ntej thiab tom qab ntawd txo qis. Thaum qhov sib ntxiv ntawm Sorbitol yog hais txog 0.15%, lub elongation thaum so mus txog 45% thiab lub zog tensile yog li 55MPA.
5) Ntxiv rau ntawm ob lub tshuab yas, glycerol thiab sorbitol, ob leeg txo cov khoom siv kho tshiab thiab dej solubility ntawm HPMC cov yeeb yaj kiab, thiab kev txo qis tsis zoo. Muab piv cov nyhuv yas ntawm ob lub tshuab yas rau ntawm HPMC cov yeeb yaj kiab, nws tuaj yeem pom tau tias cov txiaj ntsig zoo ntawm glycerol yog qhov zoo dua li ntawm sorbitol.
6) Through infrared absorption spectroscopy (FTIR) and wide-angle X-ray diffraction analysis, the cross-linking of glutaraldehyde and HPMC and the crystallinity after cross-linking were studied. Nrog rau ntxiv ntawm Cross-txuas tus neeg sawv cev Glutaraldehyde, elongation ntawm kev tawg HPMC cov yeeb yaj kiab ua ntej nce thiab tom qab ntawd poob. Thaum qhov sib ntxiv ntawm glutaraldehyde yog 0.25%, cov khoom siv neeg kho mob hauv HPMC yog qhov zoo dua; Tom qab kev sib hla hla, dej-solubility lub sijhawm yog lub sijhawm ntev, thiab dej-solubility txo. Thaum qhov sib ntxiv ntawm glutaraldehyde yog 0.44%, lub sijhawm dej-solubility ncav cuag li 135min.
7) Ntxiv tus nqi tsim nyog ntawm AOBS NETERMENT rau cov yeeb yaj kiab zaj duab xis ntawm HPMC zaj duab xis, lub npaj Aob / hpmc dej-sololle ntim ntawm anti-oxidation. Lub Aob / HPMC zaj duab xis nrog 0.03% Aob ntxiv rau 0.03% Aob ua rau tshem tawm tus nqi yog qhov zoo tshaj plaws, uas yog 61% siab tshaj li ntawm HPMC zaj duab xis tsis muaj aob. Cov dej solubility yog tseem txhim kho, thiab cov khoom siv neeg kho mob thiab kho qhov muag tau tsawg dua. Thaum qhov kev sib ntxiv ntawm 0.03% AOB, cov yeeb yaj kiab tiv thaiv oxidation ntawm kev tawm tsam AB / HPMC nthuav tawm cov ntawv thov ntawm cov khoom ua ntej ntim khoom hauv cov zaub mov ntim khoom noj.
Lub sijhawm Post: Sep-29-2022