1. Cov khoom tseem ceeb ntawm HPMC
Hypromellose, English npe hydroxypropyl methylulose, alias HPMC. Nws cov roj molecular yog c8h15o8- (c10hl8o6) n-c8hl5o8, thiab nws cov khoom siv hluav taws xob, uas yog ib feem ntawm methyl thiab ib feem ntawm polyhydroxypropy cellulopose. Nws tuaj yeem tsim los ntawm ob txoj kev: Ib qho yog tias tsim nyog cov qib ntawm methyl cellulose tau kho nrog epylene oxide hauv qab kub thiab siab. Daim foos txuas nrog rau lub anhydoglulucose nplhaib ntawm cellulose, thiab tuaj yeem ncav cuag cov qib zoo tagnrho; Lwm tus yog kho cov paj rwb lamin lossis ntoo pulp fiber ntau nrog cov tshuaj methylide thiab tom qab ntawd ua kom zoo dua qub, thiab tom qab ntawd ua kom zoo dua qub, hmoov av zoo thiab hnav khaub ncaws zoo. HPMC yog ntau yam ntawm ntuj cog cellulose, thiab nws kuj yog ib qho kev zam zoo tshaj plaws, uas muaj ntau qhov chaw. Tam sim no, nws yog dav siv nyob hauv tsev thiab txawv teb chaws, thiab nws yog ib qho ntawm cov tshuaj uas muaj kev cia siab tshaj plaws hauv kev siv tshuaj.
Cov khoom no yog dawb rau milky dawb hauv cov xim, tsis muaj tshuaj lom thiab tsis muaj qab hau, thiab yog nyob rau hauv daim ntawv ntawm granular lossis fibrous hmoov uas ntws tau yooj yim. Nws yog qhov ruaj khov nyob rau hauv lub teeb kis lub teeb thiab cov av noo. Nws swells nyob rau hauv dej txias los ua ib lub milky dawb colloidal tov, uas muaj qee qhov kev hloov pauv ntawm Sol-Gel sib tshuam tuaj yeem tshwm sim vim qhov ntsuas kub ntawm qee qhov kev daws teeb meem. It is very soluble in 70% alcohol or dimethyl ketone, and will not dissolve in absolute alcohol, chloroform or ethoxyethane.
Thaum phy ntawm hypromellose yog nruab nrab ntawm 4.0, nws muaj qhov ruaj khov zoo, thiab nws tuaj yeem muaj tshwm sim thaum lub p yog ntawm 3.0 thiab 11.0. Thaum qhov ntsuas kub yog 20 ° C thiab cov txheeb ze vaum yog 80%, nws yog khaws cia rau 10 hnub. Kev nqus dej noo kev ua noj coefficient ntawm HPMC yog 6.2%.
Vim muaj cov ntsiab lus sib txawv ntawm methoxy thiab hydroxypropyl nyob rau hauv cov qauv ntawm hypromellose, ntau hom khoom tau tshwm sim. Hauv kev sib txawv, ntau hom khoom muaj cov viscosity thiab thermal gelation kub, yog li ntawd, muaj cov khoom sib txawv thiab tuaj yeem siv rau cov laj thawj sib txawv. Lub chaw muag tshuaj ntawm ntau lub tebchaws muaj cov kev cai sib txawv thiab cov sawv cev ntawm cov khoom lag luam sib txawv thiab cov neeg nyob sab Europe Hauv Tebchaws Meskas Cov Pharcacopoeia, Lub Npe Tshaj Tawm ntxiv 4 tus lej ntawm cov ntsiab lus ntawm kev kwv yees li ntawm Hypromellose, thiab ob tus lej kawg sawv cev rau hydroxypropyl ntev feem pua ntawm.
2. Tus qauv ntawm kev ua tiav HPMC hauv dej
2.1 Cov Dej Dej Kub
Txij li thaum hypromellose tsis yaj hauv dej kub, nws tuaj yeem sib txawv ua rau muaj dej kub thaum pib, thiab tom qab ntawd txias. Ob txoj hauv kev tau piav raws li nram qab no:
(1) Muab cov dej kub uas yuav tsum muaj dej kub rau hauv lub khob dej, thiab tom qab ntawd maj mam ntxiv cov slurry, nplawm txias cov slurry cia.
(2) Ntxiv rau 1/3 lossis 2/3 ntawm qhov uas yuav tsum tau dej los npaj cov dej txias lossis dej khov kom sov rau hauv cov dej txias, cov sib tov yog txias tom qab nplawm.
2.2 Hmoov sib xyaw txuj
Cov hmoov nplej yog tag nrho cov kev sib xyaw ua ke los ntawm kev sib xyaw qhuav nrog qhov sib npaug lossis ntau dua ntawm lwm cov khoom xyaw uas muaj hmoov. Nyob rau lub sijhawm no, lub hypromellose tuaj yeem yaj tsis muaj agglomeration.
3. Qhov zoo ntawm HPMC
3.1 Lub cev dej txias
Soluble hauv dej txias hauv qab 40 ° C lossis 70% ethanol, nyob hauv paus hauv dej kub saum 60 ° C, tab sis yuav yog gelled.
3.2 Tshuaj lom neeg inertness
Hypromellose (HPMC) yog hom ntawm cov tsis muaj ionic cellulose ether. Nws cov kev daws teeb meem tsis muaj ionic them thiab tsis cuam tshuam nrog cov kav hlau hlau lossis ionic organic sib txuas. Yog li ntawd, lwm yam kev zam tsis yog kev tawm tsam nrog nws thaum lub sijhawm npaj.
3.3 Txom Nyem
Nws yog qhov ruaj khov rau cov kua qaub thiab alkali, thiab tuaj yeem khaws cia ntev li ntawm PH 3 thiab 1L tsis muaj kev hloov pauv pom ntawm viscosity. Cov tshuaj aqueous ntawm hypromellose (HPMC) muaj cov nyhuv anti-mildew effect thiab tuaj yeem tswj cov viscosity zoo thaum lub sijhawm ntev cia. Kws Tshuaj HPMC kom zoo siab muaj cov khoom ruaj khov zoo dua li cov uas siv Dextrin, cov hmoov txhuv nplej siab, thiab lwm yam).
3.4 Viscosity Kev Kho Mob
Qhov txawv viscosity ntawm HPMC tuaj yeem sib xyaw raws li cov cai sib txawv, thiab nws cov qauv zoo, yog li cov piv tau xaiv raws li cov cai.
3.5 metabolic inertia
HPMC tsis nqus tau lossis metabolized nyob rau hauv lub cev, thiab tsis muab cua sov, yog li nws yog ib qho kev nyab xeeb kev ua lag luam kev ua lag luam.
3.6 kev ruaj ntseg
Nws yog feem ntau ntseeg tias HPMC yog cov tsis muaj tshuaj lom thiab tsis yog cov khoom siv tsis zoo. Lub nruab nrab ntawm lub cev ua kom tuag rau cov nas yog 5g / kg, thiab lub nruab nrab ntawm ib qho koob tshuaj kom tuag rau nas yog 5.2g / kg. Cov koob tshuaj txhua hnub tsis muaj teeb meem rau tib neeg.
4. Daim ntawv thov ntawm HPMC hauv kev npaj
4.1 li zaj duab xis txheej khoom thiab zaj duab xis-ua cov khoom siv
Siv hypromellose (HPMC) raws li zaj duab xis-coated ntsiav tshuaj muaj tsis muaj qab hau, tab sis lawv cov khoom siv noo noo, tab sis lawv cov ntsuas qhov hnyav tau zoo dua. Cov khoom siv viscosity tsawg ntawm cov khoom lag luam dej-soluble ua yeeb yaj kiab rau cov ntsiav tshuaj Qhov kev xav tau feem ntau yog 2.0% mus rau 20%.
4.2 raws li phau ntawv thiab tsis sib haum
Qhov qis-viscosity qib ntawm cov khoom lag luam no tuaj yeem siv los ua cov phau ntawv, ntsiav tshuaj, thiab cov granule, thiab cov grancosity qib tsuas yog siv los ua phau ntawv. Cov tshuaj yaug sib txawv nrog cov qauv sib txawv thiab cov cai. Feem ntau, cov koob tshuaj ntawm binder rau cov ntsiav tshuaj granulation qhuav yog 5%, thiab cov koob tshuaj ntawm phau ntawv rau cov ntsiav tshuaj ntub cov ntsiav tshuaj yog 2%.
4.3 raws li tus neeg sawv cev ncua
Tus neeg sawv cev raug ncua yog lub hom phiaj ua kua pleev nrog cov neeg sawv cev hauv qab daus los tiv thaiv kom tsis txhob muaj cov khoom sib xyaw los tiv thaiv kom tsis txhob muaj kev sib nkag siab los ntawm cov pob. Cov neeg sawv cev tsis raug tso cai ua si ib lub luag haujlwm tseem ceeb hauv kev ua haujlwm. HPMC yog ib qho zoo tshaj plaws ntawm kev txwv tsis pub muaj cov neeg sawv cev, thiab nws lub zog sib xyaw ntawm cov khoom ruaj khov ntawm cov khoom ruaj khov, yog li siv cov khoom ruaj khov ntawm cov heterogeneous system. Lub siab-viscosity qib ntawm cov khoom lag luam no yog siv los ua kev kawm ua haujlwm npaj ua thaum muaj kev ncua rau tus neeg sawv cev. Nws muaj cov txiaj ntsig zoo ncua, yog qhov yooj yim rau redisperse, tsis lo rau phab ntsa, thiab muaj cov nplaim zoo. Cov tshuaj npaum li ib txwm yog 0.5% txog 1.5%.
4.4 raws li cov blocker, tus neeg sawv cev tawm-tso tawm thiab tus neeg sawv cev ua rau tus neeg sawv cev
Lub siab-viscosity qib ntawm cov khoom no yog siv los npaj hydrots gel Matrix cov ntsiav tshuaj, thiab muaj cov txiaj ntsig ntawm kev ncua kev tso yeeb. Nws siv kev xav yog 10% ~ 80% (W / W). Cov qib qis-viscosity yog siv los ua cov neeg sawv cev ua yeeb yam rau kev tso tawm-tso tawm lossis muab tso tawm-tso tawm. Qhov pib koob tshuaj yuav tsum muaj rau kev kho mob ntawm cov ntsiav tshuaj tuaj yeem ua tiav sai sai, thiab tom qab ntawd siv cov nyhuv kom sai, thiab kev siv ntshav tshuaj zoo yog tswj hwm hauv lub cev. Thaum hypromellose ntsib dej dej, nws hydrates los ua ib txheej gel. Lub tshuab ntawm cov tshuaj tso tawm los ntawm cov ntsiav tshuaj tawm los ntawm cov ntsiav tshuaj matrix feem ntau yog cov diffusion ntawm gel txheej thiab kev yaig ntawm cov gel txheej.
4.5 Cov kua nplaum tiv thaiv kom tuab thiab colloid
Thaum cov khoom no tau siv los ua cov tuab dua, cov siv feem ntau yog 0.45% ~ 1.0%. Cov khoom no tseem tuaj yeem nce kev ruaj khov ntawm hydrophobic kua nplaum, tiv thaiv cov lus los ntawm kev tsim ntawm sediment, thiab nws ib txwm concentration yog 0.5% ~ 1.5%.
4.6 capsule cov khoom siv rau tsiav tshuaj
Feem ntau cov ntsiav tshuaj plhaub tshuaj ntsiav ntawm cov tshuaj ntsiav yog raws li gelatin. Cov txheej txheem ntau lawm ntawm cov tshuaj pleev roj taub hau yooj yim, tab sis muaj qee qhov teeb meem thiab oxygen romicture, thiab ncua sij hawm tsis txaus ntseeg ntawm cov tshuaj ntsiav thaum cia. Yog li ntawd, hypromellose, raws li hloov chaw rau gelatin tsiav tshuaj, yog siv nyob rau hauv kev npaj cov tsiav tshuaj, uas txhim kho cov tshuaj ntsiav, thiab tau tshaj tawm nyob hauv tsev thiab txawv teb chaws.
4.7 li biadhesive
Cov thev naus laus zis ntawm kev tsim kho cov tshuaj lom neeg, kom cov tshuaj lom zem ntxiv, kom cov tshuaj ntsuab, kom cov tshuaj ntsuab los ntawm kev ua tiav cov hom phiaj kho kom zoo. Nws tam sim no dav siv nws yog siv los kho cov kab mob ntawm qhov ntswg kab noj hniav, qhov ncauj mucosa thiab lwm qhov chaw. Patrointestion butoadots technology yog qhov kev xa tshuaj tshiab tsim nyob rau xyoo tas los no. Nws tsis yog tsuas yog ncua sij hawm lub sij hawm npaj tshuaj rau hauv cov tshuaj thiab cov tshuaj tua kab mob ntawm lub plab zom mov, yog li txhim kho cov hnyuv epithelial ntawm cov tshuaj.
4.8 raws li cov ntxig gel
Raws li kev npaj ua kom zoo nkauj rau daim tawv nqaij, Gel muaj cov txiaj ntsig zoo xws li kev nyab xeeb, kev tu cev, cov txheej txheem npaj yooj yim, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo nrog tshuaj. kev taw qhia.
Lub Sijhawm Post: Feb-14-2025