HydroxyPropyyl methylcellueculose (HPMC) yog cov khoom siv polymer feem ntau siv hauv cov zaub mov, tshuaj, tshuaj pleev ib ce thiab lwm thaj teb. Nws cov qauv viscosity yog qhov ntsuas tseem ceeb cuam tshuam rau nws cov kev ua tau zoo, uas feem ntau cuam tshuam nrog HPMC, kev daws teeb meem, hom kuab tshuaj thiab kub.
1. Molecular hnyav
Qhov hnyav molecular ntawm HPMC yog ib qho tseem ceeb tshaj plaws cuam tshuam rau nws viscosity. Feem ntau hais lus, qhov loj dua cov molecular hnyav, ntev dua cov molecular chart ntawm HPMC, qhov tsis zoo ntawm lub flucosity, thiab ntau dua viscosity. Qhov no yog vim tias cov qauv ntawm macromolecular saw muab ntau cov kev cuam tshuam muaj ntau dua, ua rau cov kev txwv muaj zog ntawm cov tshuaj ntawm txoj kev daws teeb meem. Yog li ntawd, ntawm tib lub tswv yim, HPMC cov kev daws teeb meem nrog hnyav molecular hnyav feem ntau yog nthuav dav viscosities.
Qhov nce hauv molecular hnyav kuj tseem cuam tshuam rau cov khoom viscoelastic ntawm kev daws teeb meem. HPMC cov kev daws teeb meem nrog hnyav dua molecular hnyav muaj zog ua kom muaj zog ntawm cov kab mob qis dua Qhov no ua rau HPMC muaj cov kev coj cwj pwm ntau ntxiv hauv cov kev siv sib txawv hauv cov xwm txheej sib txawv.
2. Kev daws teeb meem
Qhov concentration ntawm kev daws teeb meem muaj qhov cuam tshuam tseem ceeb ntawm kev viscosity ntawm HPMC. Raws li cov concmration ntawm HPMC nce, kev sib cuam tshuam ntawm cov lwg me me hauv kev daws teeb meem nce thiab yog li muaj viscosity. Feem ntau hais lus, cov concentration ntawm kev loj hlob ntawm HPMC hauv qee qhov ntau, uas yog, tus nqi uas maj mam nce zuj zus qeeb qeeb.
Tshwj xeeb tshaj yog nyob rau hauv cov kev daws teeb meem siab, kev sib cuam tshuam ntawm molecular charets muaj zog dua, thiab cov qauv network lossis gelation yuav tshwm sim, uas yuav ntxiv cov viscosity ntawm kev daws teeb meem. Yog li ntawd, hauv kev siv cov ntawv thov, txhawm rau ua tiav viscosity tswj, nws yog feem ntau tsim nyog los kho cov kev xav ntawm HPMC.
3. Hom
Lub solubility thiab viscosity ntawm HPMC kuj muaj feem xyuam nrog hom kuab tshuaj siv. HPMC feem ntau siv cov dej ua cov kuab tshuaj, tab sis nyob rau qee cov kev mob tshwj xeeb, lwm yam kuab tshuaj xws li ethanol thiab acetone kuj tseem siv tau. Dej, raws li ib tug polar cov kuab tshuaj, tuaj yeem sib cuam tshuam muaj zog nrog cov pab pawg hydroxyl thiab methyl hauv hydmc lwg me me los txhawb nws cov kev sib cais.
Lub polarity ntawm cov kuab tshuaj, qhov ntsuas kub, thiab kev sib cuam tshuam ntawm cov kuab tshuaj thiab HPMC lwg me me yuav cuam tshuam rau Solubility thiab Viscosity ntawm HPMC. Piv txwv li, thaum lub solugent-polarity hnyav yog siv, cov solubility ntawm HPMC txo, ua rau muaj qhov qis viscosity ntawm kev daws teeb meem.
4. Kub
Cov nyhuv ntawm qhov kub ntawm lub viscosity ntawm HPMC kuj tseem muaj qhov tseem ceeb heev. Feem ntau, lub viscosity ntawm HPMC daws tau tsawg dua nrog kev nce qib kub. Qhov no yog vim tias thaum qhov ntsuas kub nce ntxiv, molecular thermal lus tsa suab nce, ua rau muaj zog ntawm kev sib cuam tshuam ntawm cov lwg me me, yog li txo qhov viscosity.
Hauv qee qhov kub kub, cov tshuaj tiv thaiv HPMC yog tsis yog tsuas yog cuam tshuam los ntawm tus nqi shear, tab sis kuj cuam tshuam los ntawm qhov kub hloov. Yog li ntawd, hauv cov ntawv thov siv, tswj qhov hloov kub ntawm qhov kub yog ib qho ntawm cov txhais tau zoo los kho cov visccosity ntawm HPMC.
5. Shear tus nqi
Lub viscosity ntawm HPMC kev daws teeb meem tsis yog cuam tshuam los ntawm cov xwm txheej zoo li qub, tab sis kuj yog los ntawm shear tus nqi. HPMC yog cov kua tsis-tshiab thiab nws viscosity hloov nrog kev hloov ntawm shear tus nqi. Feem ntau hais lus, HPMC kev daws teeb meem ntau yam ntawm cov nqi viscosity tsawg, thaum lub viscosity txo qis dua ntawm cov siab shear tus nqi. Qhov tshwm sim no hu ua Shear thinning.
Cov nyhuv ntawm shear tus nqi ntawm lub viscosity ntawm HPMC kev daws teeb meem feem ntau cuam tshuam nrog kev coj cwj pwm ntawm cov molecular. Ntawm qis shear tus nqi, molecular chains nyiam entangle ua ke, ua rau muaj ntau zog viscosity; Ntawm cov nqi shear siab dua, qhov kev sib cuam tshuam ntawm molecular chains tawg thiab lub viscosity yog tsawg.
6. PHEEJ
Lub viscosity ntawm HPMC kuj tseem cuam tshuam nrog tus nqi ntawm cov tshuaj. HPMC lwg me me muaj cov kho hydroxypropyl thiab methyl pawg, thiab them me me ntawm cov pab pawg no cuam tshuam los ntawm Ph. Nyob rau hauv qee lub p p polecules yuav ionize lossis daim ntawv gels, yog li hloov lub viscosity ntawm kev daws.
Feem ntau, hauv cov acidic lossis alkaline ib puag ncig, cov qauv ntawm HPMC tuaj yeem hloov pauv, cuam tshuam nws cov kuab tshuaj molecules thiab, nyeg, cuam tshuam rau viscosity. Thaum nyias qhov tseem ceeb, qhov ruaj khov thiab rheology ntawm HPMC cov kev daws teeb meem, yog li kev saib xyuas tshwj xeeb thaum siv PC
7. Cov nyhuv ntawm additives
Ntxiv nrog rau cov yam ntxwv saum toj no, qee cov tshuaj ntxiv xws li salts thiab surfactants kuj yuav cuam tshuam rau kev visccity ntawm HPMC. Qhov sib ntxiv ntawm cov ntsev tau hloov kho lub ionic lub zog ntawm kev daws teeb meem, yog li cuam tshuam rau solubility thiab viscosity ntawm HPMC lwg me me. Surfactants yuav hloov pauv cov qauv molecular ntawm HPMC los ntawm kev hloov pauv ntawm cov lwg me me, yog li hloov nws viscosity.
Lub visccity ntawm HPMC cuam tshuam los ntawm ntau yam, suav nrog molecular hnyav, kev daws teeb meem, kub, shear tus nqi, P muaj nuj nqis thiab ntxiv. Txhawm rau tswj cov viscosity cov yam ntxwv ntawm HPMC, cov xwm txheej no yuav tsum tau tsim nyog hloov raws li cov ntawv thov tau. Los ntawm kev nkag siab cov cuam tshuam no, kev ua tau zoo ntawm HPMC tuaj yeem ua tau zoo rau hauv kev tsim khoom sib txawv thiab cov xwm txheej ruaj khov thiab ua haujlwm hauv ntau yam kev siv.
Lub sijhawm Post: Feb-15-2025