Lub solubility ntawm hydroxypropylulose (HPMC, HydroxyPropylulose methylropsy) yog cuam tshuam los ntawm ntau yam kev siv tshuaj thiab tshuaj lom neeg thiab sab nraud ib puag ncig. Cov xwm txheej no yog qhov tseem ceeb tshaj plaws rau daim ntawv thov HPMC thiab nws cov kev ua tau zoo hauv chaw ua tshuaj, kev tsim kho thiab lwm yam kev lag luam.
1. Lub cev thiab tshuaj lom neeg
1.1 molecular hnyav
Lub cev hnyav molecular ntawm HPMC yog qhov tseem ceeb cuam tshuam rau nws solubility. Feem ntau, qhov loj dua cov molecular hnyav, qhov qeeb qeeb ntawm kev cais tawm. Qhov no yog vim hais tias ib tug loj molecular hnyav tau tshwm sim nyob ntev dua molecular loj thiab sib cuam tshuam ntawm cov lwg me me, yog li cov txheej txheem qeeb qeeb. Ntawm qhov tsis sib xws, HPMC nrog me dua molecular hnyav disasterle sai dua, tab sis nws daws viscosity tej zaum yuav qis dua, ua rau lawv tsis haum rau qee cov ntawv thov.
1.2 Qib Tawm Tsam
Cov qib kawm ntawm HPMC (piv txwv li cov degree hloov chaw ntawm methoxy thiab hydroxypropoxy pawg) kuj cuam tshuam nws solubility. HPMC nrog qib siab ntawm metoxy thiab hydroxyprropoxy hloov feem ntau muaj solubility zoo dua rau hauv hydecule thiab txhawb kev siv dej. Txawm li cas los xij, hloov chaw ntau dhau yuav ua rau cov solubility ntawm HPMC hauv qee cov kuab tshuaj, uas muaj feem xyuam rau cov kuab tshuaj thiab cov kev sib txuas lus molecular.
1.3 Qhov loj me me
Lub particle loj ntawm HPMC muaj qhov cuam tshuam ncaj qha rau nws tus lej sib cais. Qhov me me qhov loj me me, qhov ntau dua qhov tshwj xeeb thaj tsam ntawm thaj chaw hauv cov ntim ntim, thiab thaj chaw raug cov kuab nce ntxiv, yog li nrawm nrawm ntawm cov txheej txheem sib cais. Yog li, HPMC nyob rau hauv daim foos hmoov zoo feem ntau yaj sai dua li hauv coarse granular daim ntawv.
2. Hnyav mob
2.1 hom
Lub solubility ntawm HPMC sib txawv heev hauv cov kuab tshuaj sib txawv. HPMC muaj solubility zoo hauv dej, tshwj xeeb tshaj yog dej sov. Cov tshuaj tsis muaj aqueous xws li Ethanol, Propylene Glycol, thiab lwm yam. Hauv cov kuab tshuaj sib xyaw, solubility yog nyob ntawm cov sib npaug ntawm cov khoom siv thiab lawv kev sib cuam tshuam nrog HPMC.
2.2 ntsuas kub
Qhov kub muaj qhov cuam tshuam tseem ceeb rau kev solubility ntawm HPMC. Feem ntau hais lus, HPMC tau maj mam nyob hauv dej txias, tab sis raws li qhov ntsuas kub nce, thiab ua tau zoo tshaj plaws hauv dej sov ntawm 40-50 ° C. Txawm li cas los xij, nyob rau ntawm qhov kub (feem ntau dhau 70 ° C), HPMC yuav precipitate lossis tsim cov gel, uas muaj feem xyuam rau kev hloov pauv ntawm cov qauv thermodynamic thiab cov qauv daws teeb meem.
2.3 PH tus nqi
Lub solubility ntawm HPMC yog qhov ruaj khov nyob rau hauv hom sib txawv, tab sis ntau li cov kua qaub muaj zog lossis alkali) tej zaum yuav cuam tshuam nws solubility thiab ruaj khov. HPMC feem ntau muaj cov solubility zoo tshaj plaws nyob rau hauv nruab nrab lossis ze-nruab nrab p tus mob.
3. Sab nraud ib puag ncig
3.1 Tsuaj Kev Mob
Lub stirring ceev thiab txoj kev muaj qhov cuam tshuam tseem ceeb ntawm kev sib txawv ntawm HPMC. Qhov tsim nyog nplawm tuaj yeem txhawb kev tiv tauj HPMC thiab cov kuab tshuaj kom zam dhau kev tsim cov koog tas, yog li ua kom nrawm dua cov txheej txheem sib cais. Nplawm dhau sai sai yuav ua rau cov npuas rau daim ntawv, cuam tshuam rau kev sib txawv ntawm kev daws teeb meem.
3.2 Ntxiv
Lwm cov kev sib ntxiv hauv kev daws, xws li salts, electrolytes, surfolytes, etc., yuav cuam tshuam rau kev solubility ntawm HPMC. Piv txwv li, qee yam ntsev yuav txhawb nqa kev sib cais ntawm HPMC, thaum lub siab qhov siab ntawm electrolytes yuav ua rau muaj nag lossis daus los yog visccity hloov ntawm HPMC. Qhov sib ntxiv ntawm surfactants tuaj yeem txhim kho cov solubility ntawm HPMC hauv qee cov kuab tshuaj tsis-areque thiab ua kom zoo ntawm kev daws teeb meem.
4. Daim ntawv thov txiav txim siab
4.1 kev lag luam kws tshuaj
Hauv kev lag luam hauv kws tshuaj, HPMC tau siv dav ua cov khoom sib xyaw ua ke hauv kev tso tawm, thiab cov solubility puas cuam tshuam thiab cov tshuaj sib tw ntawm cov tshuaj. Yog li ntawd, tswj cov molecular hnyav, degree hloov chaw thiab cov xwm txheej ntawm HPMC yog qhov tseem ceeb rau kev npaj khoom siv tau zoo thiab ruaj khov.
4.2 Khoom Noj Khoom Haus Kev Lag Luam
Hauv kev lag luam khoom noj, HPMC yog siv los ua cov tuab, stabilizer thiab emulsifier. Nws cov solubility txiav txim nws cov kev tawg, kev ntxhib los mos thiab ruaj khov hauv cov zaub mov. Los ntawm kho cov kev ua tiav, daim ntawv thov nyhuv ntawm HPMC hauv cov zaub mov tuaj yeem ua tau zoo.
4.3 Kev Lag Luam Kev Tsim Kho
Hauv cov ntaub ntawv hauv tsev, HPMC yog siv los ua cov neeg saib xyuas dej, thickener thiab solubility thiab qhov kawg ntawm cov neeg nplua nuj, cov pleev thiab lwm yam khoom. Kho cov kev sib cais thiab cov txheej txheem kev thov ntawm HPMC tuaj yeem txhim kho cov nyhuv siv thiab cov khoom siv ruaj khov.
Lub solubility ntawm HPMC raug cuam tshuam rau lub cev nqaij daim tawv thiab tshuaj tua kab mob xws li cov kuab tshuaj, thiab kub, thiab lwm yam. Hauv kev siv cov kev siv, cov sububility thiab ua haujlwm ntawm HPMC tuaj yeem tsim nyog tau txais txiaj ntsig los ntawm kev xaiv ntawm kev xaiv thiab tswj hwm cov kev xav tau tshwj xeeb thiab ib puag ncig. Kev nkag siab tob ntawm cov xwm txheej no yuav pab txhim kho HPMC hauv ntau yam kev lag luam thiab muab kev txhawb nqa kev tsim kho tshiab hauv cov teb ntsig.
Lub Sijhawm Post: Feb-17-2025