HydroxyPropyyl methylcellueculose (HPMC) yog siv cov polymer, thiab cov tshuaj pleev zaub mov, suav nrog nws lub peev xwm los hloov kho cov kev coj ua thiab dej ua kom muaj hmoov. Tshaj dhau nws tus thawj ua haujlwm ua kom tuab lossis ua kom tus neeg sawv cev ntawm kev tuav hauv cov hmoov av los ntawm kev ua haujlwm tseem ceeb hauv kev siv ntau.
1. Hydration thiab o
HPMC yog hydrophilic, lub ntsiab lus nws yooj yim cuam tshuam nrog cov dej lwg me me los ntawm hydrogen tsev thiab van der WAsals rog. Thaum koom nrog cov hmoov ua qauv, HPMC abs abses los ntawm thaj chaw ib puag ncig lossis kev tawm tswv yim, ua rau kev haus dej thiab o ntawm cov saw polymer. Cov txheej txheem kev ua las voos no nce cov volume nyob hauv HPMC nyob hauv cov hmoov Matrix, cuab yeej cuab tam thiab txhim kho dej khaws cia.
2. Zaj duab xis tsim
HPMC tuaj yeem tsim cov duab nyias nyias, yooj yooj yim thaum tawg hauv dej thiab qhuav. Zaj yeeb yaj kiab no ua raws li txoj kev thaiv, tiv thaiv cov molecules dej los ntawm kev khiav tawm lub hmoov matrix. Los ntawm kev tsim lub network hydrophilic, HOLMC zaj duab xis tswj kom ya raws hauv cov hmoov, li kev txhim kho dej cov khoom siv. Qhov no yog tshwj xeeb tshaj plaws hauv cov ntawv thov xws li tswj-tso cov tshuaj duab los yog dej noo - cov tshuaj pleev xim kom zoo nkauj.
3. Particle Txheej
Hauv cov hmoov ua, hpmc tuaj yeem siv los ua cov khoom siv txheej kom hloov kho cov khoom ntawm cov khoom ntawm tus kheej. Los ntawm cov hmoov hmoov hmoov nrog ib txheej nyias ntawm HPMC, saum npoo ua ntau hydrophilic, saib xyuas cov adsorption ntawm dej lwg me me. Qhov no ua rau muaj peev xwm ua kom muaj peev xwm nce dej ntxiv raws li cov coated hais kom zoo cuab cov cuab ya kom muaj dej noo hauv cov hmoov txaj.
4. Binding thiab Adhesion
Nyob rau hauv cov qauv muaj hmoov yuav tsum tau compressed rau hauv cov ntsiav tshuaj lossis cov granules, HPMC pabcuam ua cov phau ntawv, txhawb nqa cov khoom nplaum ntawm cov khoom. Thaum lub sij hawm compression, hpmc hydrates thiab tsim viscous gel uas khi cov hmoov uas hmoov ua ke. Qhov kev khi khi no tsis tsuas yog txhim kho cov tshuab zog ntawm cov khoom kawg nkaus xwb tab sis kuj txhim kho cov dej ua kom zoo nkauj ntawm cov huab hwm coj los ntawm kev ua kom tsawg.
5. Rheological hloov kho
HPMC imparts Pseudopastic lossis shear-thinning tus cwj pwm rau aqueous daws, lub ntsiab lus nws viscosity txo nyob rau hauv shear kev nyuaj siab. Hauv cov hmoov formulations, cov khoom ntiag tug no cuam tshuam cov cwj pwm ntws thiab tuav cov yam ntxwv ntawm cov khoom. Los ntawm kev txo lub viscosity, hpmc tov kev yooj yim thiab kev faib cov khoom sib xyaw ua ke ntawm cov hmoov sib tov, ua kom cov khoom siv hydration thiab dej khaws cia.
6. GEL Tsim
Thaum HPMC hydrates nyob rau hauv lub xub ntiag dej, nws undergoes ib txheej txheem gelation, sib sau ib tug qauv sib tw ntawm peb-seem. Qhov no gel network entraps dej molecules, tsim lub pas dej noo noo nyob hauv cov hmoov matrix. Qhov raws li cov gel ua yog nyob ntawm cov yam xws li HPMC siab, hnyav hnyav, thiab kub. Los ntawm kev tswj hwm cov teeb meem no, cov qauv tuaj yeem tsim kho lub zog gel thiab dej kom muaj peev xwm ua kom haum rau cov kev thov tshwj xeeb.
HPMC muab cov khoom siv tseem ceeb ntawm cov dej tswj cov khoom muaj hmoov los ntawm kev sib xyaw ua ke, kos duab txheej, ua yeeb yam, thiab txheej txheem gelation. Los ntawm kev ua raws cov teebmeem no, tuaj yeem ua kom tiav cov hmoov ua kom zoo nkauj thiab cov ntsiav tshuaj rau cov khoom siv thiab cov khoom lag luam saib xyuas tus kheej. To taub lub luag haujlwm ntawm HPMC hauv kev khaws cov dej yog qhov tseem ceeb rau kev ua tiav cov khoom lag luam xav tau thiab ua haujlwm.
Lub Sijhawm Post: Feb-18-2025