HydroxyPropyyl methylulose (HPMC) thiab hypromellose yog cov ntsiab lus uas feem ntau siv sib hloov pauv sib hloov, tab sis lawv xa mus rau tib cov tshuaj. HPMC yog hluavtaws derivative ntawm cellulose, thiab hypromellose yog lub npe tsis muaj npe thoob ntiaj teb (Inn) ntawm cov compound no. Cov ntsiab lus no muaj feem ntau siv nyob rau hauv cov khoom lag luam thiab khoom noj, ntawm lwm tus, vim lawv cov khoom siv ntau yam.
HydroxyPropyyl methylcellulose (HPMC) / Hypromellose qauv:
HydroxyPropyyl methylulose yog hloov kho cellulose hloov polymer. Kev hloov kho tau cuam tshuam nrog kev sib ntxiv ntawm hydroxypropyl thiab methoxy pawg mus rau lub cellulose cellebone. Cellulose yog ib qho tshwm sim polysaccharide muaj cov khoom sib txuas ua ke nrog hauv β-1,4-glycosidic bonds. Kev qhia txog ntawm hydroxypropyl (Oh) CH3) thiab methoxy (-och3) pawg muab cov khoom siv cellule, txhim kho nws solubility, ua rau muaj lwm yam khoom.
Cov degree ntawm kev hloov pauv (DS) yog hais txog qhov nruab nrab ntawm cov neeg nyob nruab nrab ntawm ib chav ntawm lub cev hauv lub cellulose saw. Nyob rau hauv rooj plaub ntawm HPMC, kev hloov pauv hauv DS yuav ua rau cov qib sib txawv nrog cov khoom sib txawv, ua rau cov khoom siv ntau yam rau cov ntawv thov sib txawv.
Cov yam ntxwv ntawm hydroxypropy kas methylcellose:
Solubility thiab gel tsim:
HPMC yog soluble hauv dej hla ntau qhov dav, thiab cov solubility nyob ntawm yam xws li qib ntawm qhov hnyav ntawm qhov hnyav. Lub xub ntiag ntawm hydroxyprropyl thiab mexoxy pawg ua rau nws solubility hauv dej txias, ua rau nws siv tau ntau yam.
Viscosity:
Ib qho ntawm cov khoom tseem ceeb ntawm HPMC yog nws lub peev xwm los hloov viscosity ntawm kev daws teeb meem. Cov qhab nia sib txawv ntawm HPMC nrog cov viscosies sib txawv yog muaj nyob ntawm qhov uas muaj kev xav tau ntawm cov qauv.
Zaj duab xis tsim cov khoom:
HPMC cov ntaub ntawv ntshiab thiab hloov tau cov yeeb yaj kiab, ua rau nws muaj txiaj ntsig zoo hauv cov ntawv thov txheej hauv cov tshuaj thiab khoom noj khoom haus. Zaj duab xis-tsim cov khoom yog qhov tshwj xeeb tshaj yog nyob rau hauv kev tsim cov khoom noj tshuaj thiab kev sib cav sib ceg.
Stablize:
HPMC cov khoom ua pov thawj kev ruaj khov hla lub xov tooj dav, ua rau nws cov versatility hauv cov qauv sib txawv. Nws tiv taus enzymatic degradation thiab microbial nres, ua kom muaj kev ruaj ntseg ntawm cov khoom siv tshuaj.
Cov Ntaub Ntawv Siv Khoom:
Ntsiav Tshuaj Ntsiav Tshuaj:
HPMC tau dav siv hauv kev lag luam tshuaj rau cov ntsiav tshuaj txheej. Zaj duab xis ua haujlwm pab ntau lub hom phiaj, suav nrog saj cov ntaub npog ntsej muag, tiv thaiv cov tshuaj los ntawm ib puag ncig qhov tseem ceeb, thiab muab tso tawm.
Kev Pab Txhawb Kev Tso Tawm:
Tswjhwm thiab muaj kev tso tawm cov tshuaj yog qhov tseem ceeb ntawm kev tsim tshuaj. HPMC yog siv los tsim cov txheej txheem matrix uas tso cai rau cov khoom xyaw maj mam (APIs) dhau sijhawm.
Ophthalmic npaj:
Hauv ophthalmic tsim, HPMC yog siv los ua kom lub viscosity ntawm qhov muag poob thiab lub sijhawm ntev nrog qhov ocular nto. Qhov no txhim kho cov nyhuv kho ntawm cov tshuaj.
Cov ntaub ntawv tshaj tawm thiab hloov chaw ntxiv:
HPMC tau sib xyaw ua ke cov ntsiab lus ntawm cov yeeb yaj kiab thiab cream kom muab viscosity thiab txhim kho cov khoom lag luam muaj peev xwm. Nws kuj yog siv nyob rau hauv kev hloov chaw rau thaj chaw kom tswj cov tshuaj tso tawm los ntawm daim tawv nqaij.
Cov kua hauv ncauj:
HydroxyPropyyl methylcellulose yog siv nyob rau hauv kev tsim cov ntaub ntawv ntawm lub qhov ncauj kua los txhim kho viscority, ncua hais kom muab cov lus hais, thiab txhim kho palatability.
Khoom Noj Khoom Noj Khoom Noj:
Thickener:
HPMC yog siv los ua cov neeg sawv cev tuab ntawm ntau yam khoom noj, suav nrog cov kua ntses, hnav khaub ncaws, cov khoom qab zib. Nws lub peev xwm hloov viscosity pab rau cov khoom kawg ua tiav cov kev xav tau.
Thickener:
Hauv qee daim ntawv thov cov khoom noj, HPMC tuaj yeem ua raws li tus neeg sawv cev ntawm tus neeg tsim lossis pab ua kom muaj zog lossis ruaj khov emulsions.
Iav thiab tsho tiv no:
HPMC yog siv nyob rau hauv cov zaub mov noj thiab txheej txheej kom txhim kho cov nplaum, tsos thiab noo noo khaws cia. Nws ua ib zaj yeeb yaj kiab pob tshab uas ua kom cov khoom siv pom ntawm cov khoom noj.
Rog Hloov:
Ua ib lub hydrocolloidoid, HPMC tuaj yeem siv los ua cov roj hloov hauv cov khoom noj muaj rog lossis cov khoom noj tsis muaj roj, muab cov khoom siv tsis muaj roj thiab cov khoom siv ua kom zoo sib xws nrog cov rog muaj rog.
Cov kev sib tw thiab kev saib xyuas:
Thaum hydroxypropyl methylulose yog cov khoom siv ntau ntau, muaj qee yam kev txiav txim siab thiab cov kev sib tw hauv nws daim ntawv thov:
Kub rhiab:
Lub solubility ntawm HPMC cuam tshuam los ntawm qhov kub. Qee qib yuav nthuav qhia cov solubility uas yuav tsum ua tib zoo saib xyuas hauv kev tsim qauv.
Hygroscopicity:
HPMC yog hygroscopic, lub ntsiab lus nws tau yooj yim nqus dej los ntawm ib puag ncig. Cov cuab yeej no yuav tsum tau txiav txim siab nyob rau hauv cov qauv uas cov dej noo yog qhov tseem ceeb.
Tshuaj-polymer sib xyaw:
Hauv cov ntawv thov tshuaj, kev sib xyaw ntawm cov tshuaj thiab polymer yog qhov tseem ceeb kom paub meej tias qhov ruaj khov thiab ua tau zoo ntawm cov khoom kawg.
Kev cai tswj hwm:
HydroxyPropyyl methylculose tau lees txais thiab pom zoo los ntawm cov koom haum tswj hwm xws li Asmeskas Cov Chaw Tswj Tshuaj (FDA tshuaj noj (FDA tshuaj kho mob (EMA). Nws muaj npe nyob hauv cov tshuaj papeargeia raws li kev pom zoo rau kev npaj tshuaj tshuaj.
HydroxyPropyyl methylulose, feem ntau yog hu ua hypromellose, yog ib qho kev ua haujlwm ntau polymer nrog ntau yam ntawm cov ntaub ntawv thiab khoom noj khoom haus. Nws cov khoom tshwj xeeb, suav nrog solubility, suav nrog kev tawm suab, zaj duab xis-tsim muaj peev xwm thiab ruaj khov, ua rau nws muaj txiaj ntsig zoo hauv ntau hom.
Los ntawm cov ntsiav tshuaj pleev xim thiab ncua-tso tawm cov kws ua yeeb yam hauv cov tshuaj, HPMc plays lub luag haujlwm tseem ceeb hauv kev txhim kho cov khoom noj thiab cov khoom ntawm ntau yam khoom. Lub peev xwm los txiav nws cov khoom los ntawm kev kho cov qib hloov pauv thiab hnyav hnyav ntxiv nrog nws cov ntawv thov sib txawv.
Lub Sijhawm Post: Feb-19-2025