Hypromellose (HPMC) yog lub cellulose derivative uas tau siv dav hauv kev lag luam muag tshuaj vim nws cov kev ua haujlwm zoo thiab biocompatibility. Nws cov chaw thov tseem ceeb muaj cov ntsiav tshuaj lossis cov ntaub ntawv tsis sib xws, cov tshuaj thiab cov kua pleev.
1. Binders
Nyob rau hauv cov ntsiav tshuaj tsim, HPMC ua phau ntawv yuav txhim kho lub zog ntawm cov tshuaj tiv thaiv kev siv tshuaj, ua rau lawv ua cov ntsiav tshuaj ruaj khov thaum lub xov xwm. HPMC Binders muaj cov txiaj ntsig zoo hauv qab no:
Txhim kho kev kho tshuab zog: lub hom phiaj maub tau tsim los ntawm HPMC nyob rau hauv lub ntsiav tshuaj pab txhim kho kev pheej hmoo ntawm fragmentation thiab kev tawg.
Txhim kho cov kev sib xyaw no: vim nws cov solubility zoo hauv dej, HPMC tuaj yeem yog cov khoom seem ntawm cov khoom siv kom ntseeg tau cov tshuaj nyob hauv txhua lub ntsiav tshuaj.
STABILITY: HPMC qhia kom ruaj khov nyob rau hauv qhov kub thiab txias, thiab tuaj yeem tswj cov qauv ntsiav tshuaj thaum tsis tshua muaj kev cuam tshuam rau ib puag ncig.
2. Kev tawg
Txoj haujlwm ntawm cov disintfrants yog kom ua cov ntsiav tshuaj disintegrate sai sai tom qab kov nrog kua los tso cov khoom siv tshuaj yeeb. HPMC tuaj yeem ua kom zoo txhawb nqa cov ntsiav tshuaj ua kom tsis sib xws vim nws cov khoom o:
Hydration o: Thaum HPMC los rau hauv kev sib cuag nrog dej, nws yuav ua kom sai sai dej thiab swell, ua rau cov ntsiav tshuaj qauv tawg, yog li tso cov khoom xyaw tshuaj.
Kho lub sijhawm tsis sib xws: los ntawm kev kho lub viscosity ntawm lub sijhawm HPMC, lub sijhawm ua kom tsis sib haum xeeb yuav raug tswj tau kom tau raws li cov kev tso cai tso tawm.
3. Txheej ntaub ntawv
HPMC ua si lub luag haujlwm tseem ceeb hauv cov ntsiav tshuaj txheej. Nws cov yeeb yaj kiab zoo tshaj plaws thiab tiv thaiv kev cuam tshuam rau cov tshuaj ua rau nws cov txheej txheej zoo tagnrho:
Cov nyhuv rho tawm: HPMC txheej tuaj yeem ua tau zoo cais cov ntsiav tshuaj los ntawm ib puag ncig sab nraud los tiv thaiv kev cuam tshuam, oxidation thiab Photolysis.
Txhim kho tsos: HPMC txheej tuaj yeem muab cov txheej sab sab nraud, txhim kho cov tsos thiab yooj yim ntawm kev nqos ntawm cov ntsiav tshuaj.
Kho cov tshuaj tso tawm: los ntawm kev sib txawv HPMC tsim thiab coating thickinges, tswj tso tawm lossis kev tso tawm tau los yog ua tiav.
4. Kev Tawm Tsam-Tso Tawm
HPMC tau dav siv nyob rau hauv kev tsim txom-tso tawm. Los ntawm Gel Barrier nws cov ntaub ntawv, nws tuaj yeem ncua kev tso yeeb tshuaj thiab ua tiav kev kho mob ntev:
Gel Barrier: Hauv cov xov xwm aqueous, hpmc dissiblves thiab ua cov hom gel, uas tuaj yeem tswj hwm cov tshuaj tso tawm.
Ruaj Ntseg: Lub viscosity thiab concentration ntawm HPMC tuaj yeem tswj tau qhov tseeb kom ua tiav tau ruaj khov thiab twv kev tso yeeb yaj xwm.
Txo cov tshuaj noj tsawg zaus: Kev pab them nqi tshuaj yuav txo tau cov tshuaj thiab txhim kho kev ua raws cai.
5. Kev tso kua thiab cov kua txiv
HPMC ua si lub luag haujlwm tseem ceeb yog cov tuab dua thiab cov tawv nqaij hauv cov kua npaj thiab gels:
Thickening cov nyhuv: HPMC ua ib qho kev daws teeb meem colloloidal hauv dej, uas tuaj yeem ua kom cov viscosity ntawm kev npaj ua kua thiab txhim kho kom ruaj khov.
Cov nyhuv ruaj khov: HPMC tuaj yeem tswj cov viscosity nyob rau hauv ntau hom tshuaj, uas yuav pab ua kom muaj cov tshuaj sib xyaw thiab kev tawm tsam.
6. Lwm cov kev siv
HPMC kuj tseem siv los npaj ophthalmic npaj, qhov kev npaj cov txiaj ntsig thiab npaj rau daim ntawv thov kev thov:
Ophhalmic Npaj: HPMC yog siv los ua cov kua nplaum hauv cov kua muag cuav thiab qhov muag ua rau muaj cov tsos mob qhuav.
Nasal npaj: raws li lub thickener hauv qhov ntswg sprays, HPMC muaj peev xwm txuas ntxiv rau lub sijhawm khaws cov tshuaj hauv qhov ntswg.
Cov ntsiab lus npaj: HPMC tuaj yeem tsim zaj duab xis tiv thaiv hauv kev npaj tshuaj los pab tshuaj nyob rau ntawm daim tawv nqaij ntev dua.
Raws li kev ua haujlwm zoo, hydroxypropal methylcellose yog dav siv nyob rau hauv kev lag luam kws tshuaj. Nws cov haujlwm ntau hauv ntsiav tshuaj tsim, txheej, kev npaj ua kua, ua kua npaj zoo txhim kho qhov zoo thiab muaj kev phom sij ntawm kev npaj tshuaj. HPMC tau dhau los ua qhov tsis tseem ceeb thiab cov khoom tseem ceeb hauv kev lag luam muag tshuaj vim nws cov khoom lag luam zoo nkauj thiab cov khoom muaj nuj nqi. Nyob rau hauv lub neej yav tom ntej, nrog kev txhim kho kev txuas ntxiv ntawm cov tshuaj thev naus laus zis, cov ntawv thov kev cia siab ntawm HPMC hauv kev tshawb fawb tshuaj thiab kev ua qauv tsim qauv yuav dav.
Lub Sijhawm Post: Feb-17-2025