Cov neeg hais txog cellulose yog chav kawm ntawm cov khoom siv ntawm cellulose, ua yeeb yaj kiab zoo, kev ncua thiab siv dav hauv kev lag luam kws tshuaj. Vim nws cov biocompatibility thiab kev nyab xeeb, cellulose muaj cov neeg hais ua ke ua lub luag haujlwm tseem ceeb hauv kev npaj tshuaj.
1. Matrix Cov Khoom Siv rau Kev Tso Tawm-Tso Tawm
Hauv kev lag luam kev lag luam kws tshuaj, tswj kev npaj yog chav kawm npaj tshuaj uas tau ua kom ntev ntawm cov tshuaj uas tswj tau cov tshuaj tso tawm. Cov neeg hais daws cellulose feem ntau yog siv los ua cov ntaub ntawv matrix rau kev tswj hwm kev npaj rau kev npaj vim lawv lub cev tshwj xeeb thiab tshuaj lom neeg. HydroxyPropyyl methylcellulose (HPMC) yog ib qho ntawm feem ntau cov neeg ua haujlwm cellulose. Nws tuaj yeem tsim cov gel hauv dej thiab tuaj yeem tswj tau cov tshuaj tso tawm ntau. Los ntawm kev kho lub viscosity, degree hloov chaw thiab cov ntsiab lus ntawm cov yam ntxwv tso tawm ntawm cov tshuaj tuaj yeem hloov kho raws li xav tau. Qhov no ua rau cov cellulose muaj cov neeg ua haujlwm ntawm cov khoom zoo tshaj plaws rau kev tso tawm-tso tawm, tswj-tso tawm thiab txuas ntxiv tawm tswv yim.
2. Tablet Binders
Hauv kev tsim cov ntsiav tshuaj, cellulose muaj kev hais txog kev pab cuam yog siv los ua cov tshuaj thiab kev kho tshuab lub zog ntawm cov ntsiav tshuaj. Tshwj xeeb tshaj yog nyob rau hauv cov txheej txheem ntub cov txheej txheem, sodium Carbulge cellulose (HPC-NA) thiab Hydroxymal Cellulose (HPC) yog txhim kho cov nplaum, yog li ua kom muaj kev ruaj khov thiab ruaj khov ntawm cov ntsiav tshuaj. Tsis tas li ntawd, kev thov cov tshuaj uas muaj kev nyab xeeb hauv cov ntsiav tshuaj kuj tseem tuaj yeem txhim kho cov ntsiav tshuaj sai sai, yog li cov tshuaj muaj peev xwm tau sai sai rau hauv lub cev thiab txhim kho bioavailability.
3. Zaj duab xis txheej txheej
Cov neeg muaj neeg ua haujlwm pab neeg cellulose tseem muaj siv dav hauv ntsiav tshuaj pleev xim. Raws li txheej txheej, hydroxypropyl methylcelulose muaj cov yeeb yaj kiab zoo nkauj thiab tuaj yeem txhim kho qhov ruaj khov, noo noo tsis kam thiab kev tshwm sim ntawm cov ntsiav tshuaj siv tshuaj yeeb. Cellulose arthage yeeb yaj kiab tseem tuaj yeem ncua kev tso tawm yeeb tshuaj kom ua tiav kev tso tawm lossis nkag rau hauv cov teebmeem. Ib qho ntxiv, los ntawm kev sib xyaw ua ke cov neeg ua haujlwm cellulose nrog lwm cov txheej txheem sib txawv, xws li txheej txheem sib txawv, thiab kom tau raws li cov kev xav tau ntawm cov tshuaj sib txawv.
4. Thickeners thiab stabilizers
Hauv kev npaj ua kua, emulsions thiab ncua, cellulose muaj cov neeg hais ua txoj haujlwm tseem ceeb li cov tuab thiab stabilizers. Nws tuaj yeem nce viscosity ntawm kev daws teeb meem thiab txhim kho kev ncua ntawm cov tshuaj, yog li ua kom muaj kev sib txawv thiab kev ruaj khov ntawm cov tshuaj. Piv txwv li, hauv ophthalmic npaj thiab qhov ncauj thiab lub ntsej muag cellulose thiab muaj kev ruaj khov ntawm cov tshuaj thaum siv. Tsis tas li ntawd, cellulose muaj kev hais ua tau zoo nyob rau hauv cov nqe lus ntawm biocompatibility thiab lom, thiab tsis ua xua rau lawv tshwj xeeb siv nyob rau hauv cov tshuaj ophthalmic.
5. Cov ntaub ntawv phab ntsa rau cov tshuaj ntsiav npaj npaj
Cov ntaub ntawv hais txog cov cellulose tseem tuaj yeem siv los ua cov ntaub ntawv phab ntsa rau kev npaj tshuaj ntsiav, tshwj xeeb tshaj yog nyob rau hauv kev npaj cov ntsiav tshuaj. Cov tshuaj ntsiav ib puag ncig phab ntsa yog mas cov txiv neej, tab sis nrog rau cov neeg tsis huv thiab cov neeg muaj kuab, qhov kev thov rau cov tshuaj ntsiav tshuaj los ntawm cov khoom cog qoob loo tau nce ntxiv. Cellulose muaj kev hais ua ke xws li hydroxyprropy cog methylcellulose tau dhau los ua qhov tseem ceeb ntawm cov ntsiav tshuaj cog qoob loo. Hom tshuaj ntsiav tsis tsuas yog muaj solubility zoo, tab sis kuj tseem muab cov tshuaj ntsuab muaj zog rau gelatin cov ntsiav tshuaj, tau hais txog cov neeg noj zaub mov thiab cov neeg tsis muaj tshuaj rau cov ntaub ntawv tshuaj.
6. Daim ntawv thov hauv qhov ncauj thiab npaj kev npaj
Cellulose Cov neeg muaj kev hais ua tau tseem tau siv dav hauv qhov ncauj thiab npaj kev npaj. Vim tias nws cov lus nplaum zoo thiab biocompatibility, cellulose cov neeg hais ua ke tuaj yeem tsim zaj duab xis lossis ua kom ntev ntev lub sijhawm ntawm kev ua yeeb yam ntawm qhov chaw ntawm kev nqis tes ua. Piv txwv li, nyob rau hauv orasalastaste ntsiav tshuaj, cov tshuaj txhuam hniav thiab cov tshuaj pleev cellulose tuaj yeem ua ib tus neeg nqa tshuaj thiab txhim kho cov teebmeem hauv zos.
7. Microencapsulation thiab Cov Khoom Siv Tshuaj Yeeb Tshuaj
Cov neeg hais kom lwm tus neeg hais kom muaj kev hais kom lwm tus kuj tseem siv tau rau kev tsim kho cov tshuaj microencapsulation thiab cov tshuaj xa tshuaj. Thaum npaj microcapsules lossis nanoparticles, cov kws ua haujlwm cellulose feem ntau siv los ua cov ntaub ntawv phab ntsa lossis cov neeg nqa khoom kom ua tiav thiab txawm tias cov khoom xa tuaj ntawm cov tshuaj encapsulating. Piv txwv li, hydroxypropyl methylulose thiab carboxymethyl cellulose ua si ib lub luag haujlwm tseem ceeb hauv kev npaj ntev-ua tshuaj rau cov tshuaj microensulated tshuaj. Cov neeg muaj kev pab cuam cellulose tsis tuaj yeem tiv thaiv kev tiv thaiv los ntawm cov txiaj ntsig ntawm cov tshuaj muaj roj hauv lub cev los ntawm kev tswj hwm qhov kev tso tawm.
Cov neeg hais txog cellulose tau siv dav hauv kev lag luam khoom siv, cov tshuaj ntsuab, thiab tshuaj lom neeg thiab cov tshuaj tseem ceeb hauv kev txhim kho cov tshuaj npaj. Nrog kev txhim kho kev ua lag luam tas mus li, cov ntaub ntawv uas muaj kev cuam tshuam ntxiv, cov tshuaj uas muaj kev hais ua cellula, cellulose neeg yuav ua txuas ntxiv mus ua lub luag haujlwm tseem ceeb.
Lub Sijhawm Post: Feb-17-2025