Joseph Brama tsim cov txheej txheem Extrusion rau kev tsim cov hmoov txhuas nyob hauv lub xyoo pua 18th. Nws tsis yog kom txog rau thaum nruab nrab ntawm lub xyoo pua puv 19 uas kub-melt extrusion tshuab pib siv hauv cov plastics kev lag luam. Nws tau siv thawj zaug hauv kev tsim cov tshuaj insulating polymer rau cov xov hluav taws xob. Hnub no kub yaj extrusion tshuab yog dav siv tsis tsuas yog tsim cov khoom lag luam polymer, tab sis kuj muaj kev tsim khoom thiab sib xyaw ntawm cov polymers lawv tus kheej. Tam sim no, ntau dua ib nrab ntawm cov khoom lag luam yas, suav nrog hnab yas, yas los thiab kav yas, yog tsim kev siv tus txheej txheem no.
Tom qab ntawd, cov thev naus laus zis maj mam tshwm sim hauv cov chaw muag tshuaj thiab maj mam dhau los ua kev siv thev naus laus zis. Tam sim no cov neeg siv kub-yaj Extrusion Tshuab los npaj cov ntsiav tshuaj, kev xa tshuaj thiab transdermal thiab vim li cas tib neeg nyiam thev naus laus zis tam sim no? Qhov laj thawj yog feem ntau yog tias muab piv nrog cov txheej txheem ib txwm ua hauv yav dhau los, kub yaj extrusion tshuab muaj cov txiaj ntsig hauv qab no:
Txhim kho qhov sib cais ntawm cov tshuaj tsis zoo
Muaj cov txiaj ntsig los npaj cov qauv ua tiav-tso tawm
Npaj ntawm cov pa roj plab tso tawm cov neeg sawv cev nrog qhov chaw raug
Txhim Kho Kom Zoo Siab
Cov txheej txheem slicing yog qhov pom tau hauv ib kauj ruam
Qhib txoj kev tshiab rau kev npaj ntawm micropellets
Ntawm lawv, cellulose ua lub luag haujlwm tseem ceeb hauv cov txheej txheem no, cia peb saib ntawm daim ntawv thov ntawm peb cov cellulose ether hauv nws!
Kev siv cov tshuaj tua kab ntawm Ethylulose
Ethyl cellulose yog ib hom ntawm hydrophobic ether cellulose. Hauv cov chaw muag tshuaj, nws tam sim no siv nyob rau hauv cov tshuaj thiab cov ntsiav tshuaj granulation, cov ntsiav tshuaj piping thiab raws li txheej txheem rau tswj cov ntsiav tshuaj thiab cov hlaws dai. Cov cellulose Etheny tuaj yeem nce ntau yam hnyav molecular. Nws cov iav hloov cua kub yog 129-133 degrees Celsius, thiab nws cov Crystal Melting taw tes yog rho 180 degrees Celsius. Cov cellulose Ethylas yog qhov kev xaiv zoo rau extrusion vim nws cov khoom ua pov thawj thermoplastic cov khoom saum toj no nws qhov kev hloov pauv kub thiab qis dua nws qhov kub nyhiab.
Txhawm rau txo qis lub khob hloov cua sov ntawm polymers, cov qauv feem ntau yog ntxiv cov tshuab yas, yog li nws tuaj yeem ua tiav ntawm qhov kub tsawg. Qee cov tshuaj tuaj yeem ua cov yas ua lawv tus kheej, yog li tsis tas yuav rov tsim cov tshuab yas ntxiv thaum cov txheej txheem ua yeeb yam. Piv txwv li, nws tau pom tias cov yeeb yaj kiab extruded muaj cov menprofen thiab Ethylfoulose muaj qhov ntsuas kub qis dua li cov yeeb yaj kiab uas muaj cov yeeb yaj kiab tsuas yog cov yeeb yaj kiab tsuas yog cov yeeb yaj kiab nkaus xwb. Cov yeeb yaj kiab no tuaj yeem ua rau hauv chav kuaj nrog co-rotating ntxaib-ntsia hlau extruders. Cov kws tshawb nrhiav kuj ua rau nws ua rau hauv cov hmoov thiab tom qab ntawd ua cov tshuaj ntsuam thermal. Nws muab tawm uas nce tus nqi ntawm ibuprofen tuaj yeem txo qis lub khob hloov cua sov.
Lwm sim yog ntxiv hydrophilic zam, hypromellose, thiab xanthan ntawm cov pos hniav mus rau ethylcellulose thiab ibuprofen micromatines. Nws tau xaus lus tias cov micromatrix uas tsim los ntawm qhov txheej txheem halt-melten tau muaj cov tshuaj uas muaj kev sib haum xeeb dua li cov khoom lag luam muaj. Cov kws tshawb nrhiav tau ua cov micromatrix siv cov co-rotating sim sim ntsuas thiab ib qho kev sib tw twin-scrinder nrog ib tug 3-hli cylindrical tuag. Kev txhais tes txiav extruded cov ntawv txheeb tau 2 hli ntev.
Hypromellose siv
HydroxyPropylenCellulose yog hydrophilic cellulose etherhais uas swogy colloidal tov hauv dej txias. Cov tshuaj aqueous muaj cov haujlwm saum npoo av, siab transparency thiab ruaj khov ua tau zoo. Solubility sib txawv nrog viscosity. Qhov qis dua viscosity, muaj ntau dua cov solubility. Cov yam ntxwv ntawm hydroxypropylulose nrog cov sib txawv sib txawv sib txawv, thiab nws cov kev sib cais hauv dej tsis cuam tshuam los ntawm tus nqi PH.
Nyob rau hauv kev lag luam kws tshuaj, feem ntau nws siv hauv kev tswj cov khoom siv hluav taws xob, thiab lwm yam hloov pauv ntawm Hydroius, nws cov qauv hloov pauv, nws qhov ntsuas kub tshaj 250 degrees Celsius. Vim tias nws lub iav transition kub thiab qhov qis qis kub, nws tsis dav siv nyob rau hauv kub yaj extrusion tshuab. Txhawm rau nthuav dav ntawm kev siv, ib txoj kev yog tsuas yog ua ke cov roj txheem tsim kom muaj ob tus kws tshawb fawb no, thiab siv ib qho kev tsim kho ob leeg cov yas muaj tsawg kawg yog 30%.
Cov tshuaj ethylcellose thiab hydroxyprropylroylsylcethylcellulose tuaj yeem ua ke hauv kev tshwj xeeb hauv kev xa tshuaj. Ib qho ntawm cov ntaub ntawv ntau npaum li no yog los siv tshuaj tiv thaiv kev coj ua kom zoo li cov raj sab nraud, thiab tom qab ntawd npaj ib qib kev sib cais. Ca cellulose core.
Lub ethylcellose tubing yog tsim kev siv kub-yaj extrusion nyob rau hauv lub tshuab hlau sib dhos, qhov tseem ceeb ntawm cov cua sov kom txog thaum nws melts, ua raws li homogenization. Cov khoom siv tseem ceeb yog tom qab ntawd manually pub rau hauv lub raj dej. Lub hom phiaj ntawm txoj kev kawm no yog tshem tawm cov nyhuv ntawm popping ntawm popping uas qee zaum tshwm sim hauv hydroxypropylulose matrix ntsiav tshuaj. Cov kws tshawb nrhiav pom tsis muaj qhov sib txawv hauv kev tso tawm tus nqi rau hydroxyprophlulose ntawm tib viscosyrcosylulose tau tshwm sim hauv kev tso tawm sai dua.
Chaw saib xyuas
Txawm hais tias kub melt extrusion yog qhov tshiab ntawm cov tshuab tshiab hauv kev tsim khoom lag luam, nws tau siv los txhim kho kev tsim ntau cov tshuaj sib txawv thiab cov tshuab. Kub-melt extrusion technology tau dhau los ua cov thev naus laus zis rau kev npaj khoom txawv txawv txawv teb chaws. Vim tias nws cov ntsiab lus kev npaj zoo ib yam li ntau txoj kev npaj rau lwm xyoo thiab tsim tau ntau yam kev paub ntau ntxiv, nws muaj kev txhim kho dav dav. Nrog rau qhov sib txawv ntawm kev tshawb fawb, nws ntseeg tau tias nws daim ntawv thov yuav raug nthuav ntxiv. Nyob rau tib lub sijhawm, qhov kub-yaj extrusion tshuab muaj tsawg dua kev sib cuag nrog cov tshuaj thiab qib siab ntawm kev siv tshuab. Tom qab hloov mus rau kev lag luam kws tshuaj, nws ntseeg tias nws GMP kev hloov pauv yuav yog qhov nrawm.
Lub Sijhawm Post: Feb-14-2025